PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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8S01	A fragment-based inhibitor of SHP2 分子名称: 3-(4-chlorophenyl)-1H-pyrazole, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
8S0O	A fragment-based inhibitor of SHP2 分子名称: 3-[4-chloranyl-2-(1H-pyrazol-4-ylmethyl)indazol-5-yl]-5-methyl-6-(piperazin-1-ylmethyl)-1H-pyrrolo[3,2-b]pyridine, FORMIC ACID, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.834 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
5WHM	Crystal Structure of IclR Family Transcriptional Regulator from Brucella abortus 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... 著者 Kim, Y, Wu, R, Tesar, C, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2017-07-17 公開日 2017-08-23 最終更新日 2019-11-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular control of gene expression byBrucellaBaaR, an IclR-type transcriptional repressor. J. Biol. Chem., 293, 2018
8SR6	Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ... 著者 Xu, C, Chung, I.Y.W, Cygler, M. 登録日 2023-05-05 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain To Be Published
8SM8	Air-oxidized A. ca TruffO expressed from M9 minimal medium supplemented with Fe 分子名称: FE (III) ION, MAGNESIUM ION, Putative amidohydrolase, ... 著者 Liu, C, Rittle, J. 登録日 2023-04-25 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bioinformatic Discovery of a Cambialistic Monooxygenase. J.Am.Chem.Soc., 146, 2024
8S07	A fragment-based inhibitor of SHP2 分子名称: 7-azanyl-N-pyridin-3-yl-3H-pyrrolo[3,2-b]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Cleasby, A, Price, A. 登録日 2024-02-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
8S0I	A fragment-based inhibitor of SHP2 分子名称: 3-phenyl-1H-pyrrolo[3,2-b]pyridine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
8SD7	Carbonic anhydrase II radiation damage RT 61-90 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Combs, J.E, Mckenna, R. 登録日 2023-04-06 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.704 Å) 主引用文献 XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. Acta Crystallogr D Struct Biol, 80, 2024
8SM9	Air-oxidized C. fi TruffO expressed from M9 minimal medium supplemented with Fe 分子名称: Amidohydrolase 2, FE (III) ION 著者 Liu, C, Rittle, J. 登録日 2023-04-25 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Bioinformatic Discovery of a Cambialistic Monooxygenase. J.Am.Chem.Soc., 146, 2024
6X5R	Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A2-Asn 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A2-Asn, ... 著者 Kadirvelraj, R, Wood, Z.A. 登録日 2020-05-26 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases. J.Biol.Chem., 295, 2020
8SCA	Rec3 Domain from S. pyogenes Cas9 分子名称: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1 著者 D'Ordine, A.M, Skeens, E, Lisi, G.P, Jogl, G. 登録日 2023-04-05 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 High-fidelity, hyper-accurate, and evolved mutants rewire atomic-level communication in CRISPR-Cas9. Sci Adv, 10, 2024
8SNZ	X-ray Crystal Structure of FMN-bound long-chain flavodoxin from Rhodopseudomonas palustris 分子名称: FLAVIN MONONUCLEOTIDE, Flavodoxin 著者 Ansari, A, Khan, S.A, Miller, A.F. 登録日 2023-04-28 公開日 2024-03-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure, dynamics, and redox reactivity of an all-purpose flavodoxin. J.Biol.Chem., 300, 2024
8SMA	SfbO with di-Manganese cofactor 分子名称: Amidohydrolase family protein, MANGANESE (II) ION, SULFATE ION 著者 Liu, C, Rittle, J. 登録日 2023-04-25 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Bioinformatic Discovery of a Cambialistic Monooxygenase. J.Am.Chem.Soc., 146, 2024
8S0Q	A fragment-based inhibitor of SHP2 分子名称: (1S,5R)-8-[3-[2,3-bis(chloranyl)phenyl]-1H-pyrrolo[3,2-b]pyridin-6-yl]-8-azabicyclo[3.2.1]octan-3-amine, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-14 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.872 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
8T0Z	Human liver-type glutaminase (K253A) with L-Gln, filamentous form 分子名称: GLUTAMINE, Glutaminase liver isoform, mitochondrial 著者 Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. 登録日 2023-06-01 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15, 2024
8S4G	Cryo-EM structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1 at 3.2 Angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. 登録日 2024-02-21 公開日 2024-03-13 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex To Be Published
8SD6	Carbonic anhydrase II radiation damage RT 31-60 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Combs, J.E, Mckenna, R. 登録日 2023-04-06 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.397 Å) 主引用文献 XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. Acta Crystallogr D Struct Biol, 80, 2024
8SD9	Carbonic anhydrase II radiation damage RT 121-150 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Combs, J.E, Mckenna, R. 登録日 2023-04-06 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.904 Å) 主引用文献 XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. Acta Crystallogr D Struct Biol, 80, 2024
8SD1	Carbonic anhydrase II radiation damage RT 1-30 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Combs, J.C, Mckenna, R. 登録日 2023-04-06 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.298 Å) 主引用文献 XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. Acta Crystallogr D Struct Biol, 80, 2024
8SF1	Carbonic anhydrase II XFEL radiation damage RT 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Combs, J.E, Mckenna, R. 登録日 2023-04-10 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures. Acta Crystallogr D Struct Biol, 80, 2024
5WQJ	Crystal structure of 3-Mercaptopyruvate Sulfurtransferase(3MST) in complex with compound1 分子名称: 2-[2-[(4-oxidanylidene-3~{H}-quinazolin-2-yl)sulfanyl]ethanoylamino]thiophene-3-carboxamide, SODIUM ION, Sulfurtransferase 著者 Suwanai, Y, Toma-Fukai, S, Shimizu, T. 登録日 2016-11-27 公開日 2017-09-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide Sci Rep, 7, 2017
8SZL	Human liver-type glutaminase (Apo form) 分子名称: Glutaminase liver isoform, mitochondrial 著者 Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. 登録日 2023-05-30 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15, 2024
5WQ9	CryoEM structure of type II secretion system secretin GspD G453A mutant in Vibrio cholerae 分子名称: Type II secretion system protein D 著者 Yan, Z, Yin, M, Li, X. 登録日 2016-11-23 公開日 2016-12-28 最終更新日 2017-02-22 実験手法 ELECTRON MICROSCOPY (4.22 Å) 主引用文献 Structural insights into the secretin translocation channel in the type II secretion system Nat. Struct. Mol. Biol., 24, 2017
8RZY	A fragment-based inhibitor of SHP2 分子名称: 1H-pyrrolo[3,2-b]pyridin-5-amine, DIMETHYL SULFOXIDE, Tyrosine-protein phosphatase non-receptor type 11 著者 Cleasby, A, Price, A. 登録日 2024-02-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
5A2Q	Structure of the HCV IRES bound to the human ribosome 分子名称: 18S RRNA, HCV IRES, MAGNESIUM ION, ... 著者 Quade, N, Leiundgut, M, Boehringer, D, Heuvel, J.v.d, Ban, N. 登録日 2015-05-21 公開日 2015-07-15 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution Nat.Commun., 6, 2015

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