8T0Z

Human liver-type glutaminase (K253A) with L-Gln, filamentous form

Summary for 8T0Z

• Entry DOI: 10.2210/pdb8t0z/pdb
• EMDB information: 40950
• Descriptor: Glutaminase liver isoform, mitochondrial, GLUTAMINE (2 entities in total)
• Functional Keywords: metabolic, cancer, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 797973.13

Authors

Feng, S.,Aplin, C.,Nguyen, T.-T.T.,Milano, S.K.,Cerione, R.A. (deposition date: 2023-06-01, release date: 2024-03-13)

• Primary citation: Feng, S.,Aplin, C.,Nguyen, T.T.,Milano, S.K.,Cerione, R.A.; Filament formation drives catalysis by glutaminase enzymes important in cancer progression.; Nat Commun, 15:1971-1971, 2024; PubMed: 38438397; DOI: 10.1038/s41467-024-46351-3

Experimental method

ELECTRON MICROSCOPY (3.3 Å)