8T0Z
Human liver-type glutaminase (K253A) with L-Gln, filamentous form
Summary for 8T0Z
Entry DOI | 10.2210/pdb8t0z/pdb |
EMDB information | 40950 |
Descriptor | Glutaminase liver isoform, mitochondrial, GLUTAMINE (2 entities in total) |
Functional Keywords | metabolic, cancer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 12 |
Total formula weight | 797973.13 |
Authors | Feng, S.,Aplin, C.,Nguyen, T.-T.T.,Milano, S.K.,Cerione, R.A. (deposition date: 2023-06-01, release date: 2024-03-13) |
Primary citation | Feng, S.,Aplin, C.,Nguyen, T.T.,Milano, S.K.,Cerione, R.A. Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15:1971-1971, 2024 Cited by PubMed: 38438397DOI: 10.1038/s41467-024-46351-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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