8T0Z

Human liver-type glutaminase (K253A) with L-Gln, filamentous form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0006543	biological_process	L-glutamine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0042981	biological_process	regulation of apoptotic process
A	0072593	biological_process	reactive oxygen species metabolic process
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0006543	biological_process	L-glutamine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0042981	biological_process	regulation of apoptotic process
B	0072593	biological_process	reactive oxygen species metabolic process
C	0004359	molecular_function	glutaminase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0006543	biological_process	L-glutamine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0042981	biological_process	regulation of apoptotic process
C	0072593	biological_process	reactive oxygen species metabolic process
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006520	biological_process	amino acid metabolic process
D	0006537	biological_process	glutamate biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0006543	biological_process	L-glutamine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0042981	biological_process	regulation of apoptotic process
D	0072593	biological_process	reactive oxygen species metabolic process
E	0004359	molecular_function	glutaminase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006520	biological_process	amino acid metabolic process
E	0006537	biological_process	glutamate biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0006543	biological_process	L-glutamine catabolic process
E	0016787	molecular_function	hydrolase activity
E	0042981	biological_process	regulation of apoptotic process
E	0072593	biological_process	reactive oxygen species metabolic process
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006520	biological_process	amino acid metabolic process
F	0006537	biological_process	glutamate biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0006543	biological_process	L-glutamine catabolic process
F	0016787	molecular_function	hydrolase activity
F	0042981	biological_process	regulation of apoptotic process
F	0072593	biological_process	reactive oxygen species metabolic process
G	0004359	molecular_function	glutaminase activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006520	biological_process	amino acid metabolic process
G	0006537	biological_process	glutamate biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0006543	biological_process	L-glutamine catabolic process
G	0016787	molecular_function	hydrolase activity
G	0042981	biological_process	regulation of apoptotic process
G	0072593	biological_process	reactive oxygen species metabolic process
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006520	biological_process	amino acid metabolic process
H	0006537	biological_process	glutamate biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0006543	biological_process	L-glutamine catabolic process
H	0016787	molecular_function	hydrolase activity
H	0042981	biological_process	regulation of apoptotic process
H	0072593	biological_process	reactive oxygen species metabolic process
I	0004359	molecular_function	glutaminase activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006520	biological_process	amino acid metabolic process
I	0006537	biological_process	glutamate biosynthetic process
I	0006541	biological_process	glutamine metabolic process
I	0006543	biological_process	L-glutamine catabolic process
I	0016787	molecular_function	hydrolase activity
I	0042981	biological_process	regulation of apoptotic process
I	0072593	biological_process	reactive oxygen species metabolic process
J	0004359	molecular_function	glutaminase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006520	biological_process	amino acid metabolic process
J	0006537	biological_process	glutamate biosynthetic process
J	0006541	biological_process	glutamine metabolic process
J	0006543	biological_process	L-glutamine catabolic process
J	0016787	molecular_function	hydrolase activity
J	0042981	biological_process	regulation of apoptotic process
J	0072593	biological_process	reactive oxygen species metabolic process
K	0004359	molecular_function	glutaminase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006520	biological_process	amino acid metabolic process
K	0006537	biological_process	glutamate biosynthetic process
K	0006541	biological_process	glutamine metabolic process
K	0006543	biological_process	L-glutamine catabolic process
K	0016787	molecular_function	hydrolase activity
K	0042981	biological_process	regulation of apoptotic process
K	0072593	biological_process	reactive oxygen species metabolic process
L	0004359	molecular_function	glutaminase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006520	biological_process	amino acid metabolic process
L	0006537	biological_process	glutamate biosynthetic process
L	0006541	biological_process	glutamine metabolic process
L	0006543	biological_process	L-glutamine catabolic process
L	0016787	molecular_function	hydrolase activity
L	0042981	biological_process	regulation of apoptotic process
L	0072593	biological_process	reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O94925","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q571F8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q571F8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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