Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8T0Z

Human liver-type glutaminase (K253A) with L-Gln, filamentous form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004359	molecular_function	glutaminase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0006543	biological_process	glutamine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0042981	biological_process	regulation of apoptotic process
A	0072593	biological_process	reactive oxygen species metabolic process
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0006543	biological_process	glutamine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0042981	biological_process	regulation of apoptotic process
B	0072593	biological_process	reactive oxygen species metabolic process
C	0004359	molecular_function	glutaminase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0006543	biological_process	glutamine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0042981	biological_process	regulation of apoptotic process
C	0072593	biological_process	reactive oxygen species metabolic process
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006520	biological_process	amino acid metabolic process
D	0006537	biological_process	glutamate biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0006543	biological_process	glutamine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0042981	biological_process	regulation of apoptotic process
D	0072593	biological_process	reactive oxygen species metabolic process
E	0004359	molecular_function	glutaminase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006520	biological_process	amino acid metabolic process
E	0006537	biological_process	glutamate biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0006543	biological_process	glutamine catabolic process
E	0016787	molecular_function	hydrolase activity
E	0042981	biological_process	regulation of apoptotic process
E	0072593	biological_process	reactive oxygen species metabolic process
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006520	biological_process	amino acid metabolic process
F	0006537	biological_process	glutamate biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0006543	biological_process	glutamine catabolic process
F	0016787	molecular_function	hydrolase activity
F	0042981	biological_process	regulation of apoptotic process
F	0072593	biological_process	reactive oxygen species metabolic process
G	0004359	molecular_function	glutaminase activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006520	biological_process	amino acid metabolic process
G	0006537	biological_process	glutamate biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0006543	biological_process	glutamine catabolic process
G	0016787	molecular_function	hydrolase activity
G	0042981	biological_process	regulation of apoptotic process
G	0072593	biological_process	reactive oxygen species metabolic process
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006520	biological_process	amino acid metabolic process
H	0006537	biological_process	glutamate biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0006543	biological_process	glutamine catabolic process
H	0016787	molecular_function	hydrolase activity
H	0042981	biological_process	regulation of apoptotic process
H	0072593	biological_process	reactive oxygen species metabolic process
I	0004359	molecular_function	glutaminase activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006520	biological_process	amino acid metabolic process
I	0006537	biological_process	glutamate biosynthetic process
I	0006541	biological_process	glutamine metabolic process
I	0006543	biological_process	glutamine catabolic process
I	0016787	molecular_function	hydrolase activity
I	0042981	biological_process	regulation of apoptotic process
I	0072593	biological_process	reactive oxygen species metabolic process
J	0004359	molecular_function	glutaminase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006520	biological_process	amino acid metabolic process
J	0006537	biological_process	glutamate biosynthetic process
J	0006541	biological_process	glutamine metabolic process
J	0006543	biological_process	glutamine catabolic process
J	0016787	molecular_function	hydrolase activity
J	0042981	biological_process	regulation of apoptotic process
J	0072593	biological_process	reactive oxygen species metabolic process
K	0004359	molecular_function	glutaminase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006520	biological_process	amino acid metabolic process
K	0006537	biological_process	glutamate biosynthetic process
K	0006541	biological_process	glutamine metabolic process
K	0006543	biological_process	glutamine catabolic process
K	0016787	molecular_function	hydrolase activity
K	0042981	biological_process	regulation of apoptotic process
K	0072593	biological_process	reactive oxygen species metabolic process
L	0004359	molecular_function	glutaminase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006520	biological_process	amino acid metabolic process
L	0006537	biological_process	glutamate biosynthetic process
L	0006541	biological_process	glutamine metabolic process
L	0006543	biological_process	glutamine catabolic process
L	0016787	molecular_function	hydrolase activity
L	0042981	biological_process	regulation of apoptotic process
L	0072593	biological_process	reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O94925

Chain	Residue	Details
A	SER219
B	GLU314
B	ASN321
B	TYR347
B	TYR399
B	VAL417
C	SER219
C	ASN268
C	GLU314
C	ASN321
C	TYR347
A	ASN268
C	TYR399
C	VAL417
D	SER219
D	ASN268
D	GLU314
D	ASN321
D	TYR347
D	TYR399
D	VAL417
E	SER219
A	GLU314
E	ASN268
E	GLU314
E	ASN321
E	TYR347
E	TYR399
E	VAL417
G	SER219
G	ASN268
G	GLU314
G	ASN321
A	ASN321
G	TYR347
G	TYR399
G	VAL417
I	SER219
I	ASN268
I	GLU314
I	ASN321
I	TYR347
I	TYR399
I	VAL417
A	TYR347
K	SER219
K	ASN268
K	GLU314
K	ASN321
K	TYR347
K	TYR399
K	VAL417
F	SER219
F	ASN268
F	GLU314
A	TYR399
F	ASN321
F	TYR347
F	TYR399
F	VAL417
H	SER219
H	ASN268
H	GLU314
H	ASN321
H	TYR347
H	TYR399
A	VAL417
H	VAL417
J	SER219
J	ASN268
J	GLU314
J	ASN321
J	TYR347
J	TYR399
J	VAL417
L	SER219
L	ASN268
B	SER219
L	GLU314
L	ASN321
L	TYR347
L	TYR399
L	VAL417
B	ASN268

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q571F8

Chain	Residue	Details
A	ALA253
H	ALA253
J	ALA253
L	ALA253
B	ALA253
C	ALA253
D	ALA253
E	ALA253
G	ALA253
I	ALA253
K	ALA253
F	ALA253

site_id	SWS_FT_FI3
Number of Residues	36
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q571F8

Chain	Residue	Details
A	LYS279
D	LYS279
D	LYS284
D	LYS329
E	LYS279
E	LYS284
E	LYS329
G	LYS279
G	LYS284
G	LYS329
I	LYS279
A	LYS284
I	LYS284
I	LYS329
K	LYS279
K	LYS284
K	LYS329
F	LYS279
F	LYS284
F	LYS329
H	LYS279
H	LYS284
A	LYS329
H	LYS329
J	LYS279
J	LYS284
J	LYS329
L	LYS279
L	LYS284
L	LYS329
B	LYS279
B	LYS284
B	LYS329
C	LYS279
C	LYS284
C	LYS329

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)