PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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5E7I	Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 分子名称: ATP-dependent RNA helicase DDX3X 著者 Floor, S.N, Condon, K.J, Doudna, J.A. 登録日 2015-10-12 公開日 2015-12-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.223 Å) 主引用文献 Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J.Biol.Chem., 291, 2016
6XVK	Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor bearing an acrylamide 分子名称: Vascular endothelial growth factor receptor 2, ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide 著者 Schimpl, M, McAuley, K, Hoyt, E.A, Thomas, M, Bodnarchuk, M.S, Lewis, H.J, Barratt, D, Deery, M.J, Ogg, D.J, Bernardes, G.J.L, Ward, R.A, Kettle, J.G, Waring, M.J. 登録日 2020-01-22 公開日 2020-05-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. J.Am.Chem.Soc., 142, 2020
6XV9	Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor 分子名称: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide 著者 Ogg, D.J, Howard, T, McAuley, K, Hoyt, E.A, Thomas, M, Bodnarchuk, M.S, Lewis, H.J, Barratt, D, Deery, M.J, Bernardes, G.J.L, Ward, R.A, Kettle, J.G, Waring, M.J. 登録日 2020-01-21 公開日 2020-05-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.38 Å) 主引用文献 Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. J.Am.Chem.Soc., 142, 2020
6XVA	Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor bearing an acrylamide 分子名称: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, ~{N}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide 著者 Schimpl, M, McAuley, K, Hoyt, E.A, Thomas, M, Bodnarchuk, M.S, Lewis, H.J, Barratt, D, Deery, M.J, Ogg, D.J, Bernardes, G.J.L, Ward, R.A, Kettle, J.G, Waring, M.J. 登録日 2020-01-21 公開日 2020-05-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. J.Am.Chem.Soc., 142, 2020
2XLJ	Crystal structure of the Csy4-crRNA complex, hexagonal form 分子名称: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE 著者 Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. 登録日 2010-07-20 公開日 2010-09-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease. Science, 329, 2010
2XQQ	Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide (Ac-SRGTQTE). 分子名称: ACETATE ION, DYNEIN LIGHT CHAIN 2, CYTOPLASMIC, ... 著者 Rapali, P, Radnai, L, Suveges, D, Hetenyi, C, Harmat, V, Tolgyesi, F, Wahlgren, W.Y, Katona, G, Nyitray, L, Pal, G. 登録日 2010-09-07 公開日 2011-05-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Directed Evolution Reveals the Binding Motif Preference of the Lc8/Dynll Hub Protein and Predicts Large Numbers of Novel Binders in the Human Proteome Plos One, 6, 2011
2XLK	Crystal structure of the Csy4-crRNA complex, orthorhombic form 分子名称: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE 著者 Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A. 登録日 2010-07-21 公開日 2010-09-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.805 Å) 主引用文献 Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease. Science, 329, 2010
2XXA	The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR) 分子名称: 4.5S RNA, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Ataide, S.F, Schmitz, N, Shen, K, Ke, A, Shan, S, Doudna, J.A, Ban, N. 登録日 2010-11-09 公開日 2011-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.94 Å) 主引用文献 The Crystal Structure of the Signal Recognition Particle in Complex with its Receptor. Science, 331, 2011
230D	SOLUTION STRUCTURES OF UNIMOLECULAR QUADRUPLEXES FORMED BY OLIGONUCLEOTIDES CONTAINING OXYTRICHA TELOMERE REPEATS 分子名称: QUADRUPLEXES DNA 著者 Smith, F.W, Schultze, P, Feigon, J. 登録日 1995-08-24 公開日 1995-10-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats. Structure, 3, 1995
2AF1	Structure of the DNA coiled-coil formed by d(CGATATATATAT) 分子名称: 5'-D(*CP*GP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3' 著者 De Luchi, D, Tereshko, V, Gouyette, C, Subirana, J.A. 登録日 2005-07-25 公開日 2006-03-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of the DNA Coiled Coil Formed by d(CGATATATATAT) Chembiochem, 7, 2006
2A2T	crystal structure of d(AAATATTT) 分子名称: 5'-D(*AP*AP*AP*TP*AP*TP*TP*T)-3', CACODYLATE ION, MANGANESE (II) ION 著者 Valls, N, Richter, M, Subirana, J.A. 登録日 2005-06-23 公開日 2005-11-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of a DNA duplex with all-AT base pairs. Acta Crystallogr.,Sect.D, 61, 2005
2AVJ	G4(Br)UTTG4 dimeric quadruplex 分子名称: 5'-D(*GP*GP*GP*GP*(BRU)P*TP*TP*GP*GP*GP*G)-3', CACODYLATE ION, POTASSIUM ION 著者 Hazel, P, Parkinson, G.N, Neidle, S. 登録日 2005-08-30 公開日 2006-03-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J.Am.Chem.Soc., 128, 2006
5W1H	Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (24-nt spacer) 分子名称: GLYCEROL, IODIDE ION, LbaCas13a (C2c2), ... 著者 Knott, G.J, Doudna, J.A. 登録日 2017-06-03 公開日 2017-09-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nat. Struct. Mol. Biol., 24, 2017
5W1I	Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (20-nt spacer) 分子名称: IODIDE ION, LbaCas13a (C2c2), mature crRNA 著者 Knott, G.J, Doudna, J.A. 登録日 2017-06-03 公開日 2017-09-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nat. Struct. Mol. Biol., 24, 2017
1XNI	Tandem Tudor Domain of 53BP1 分子名称: Tumor suppressor p53-binding protein 1 著者 Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D. 登録日 2004-10-05 公開日 2004-11-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks Nature, 432, 2004
4WOZ	Crystal Structures of CdNal from Clostridium difficile in complex with mannosamine 分子名称: 2-(ACETYLAMINO)-2-DEOXY-D-MANNOSE, N-acetylneuraminate lyase 著者 Liu, W.D, Guo, R.T, Cui, Y.F, Chen, X, Wu, Q.Q, Zhu, D.M. 登録日 2014-10-17 公開日 2015-10-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Crystal Structures of CdNal from Clostridium difficile in complex with mannosamine to be published
4WOQ	Crystal Structures of CdNal from Clostridium difficile in complex with ketobutyric 分子名称: 2-KETOBUTYRIC ACID, N-acetylneuraminate lyase 著者 Liu, W.D, Guo, R.T, Cui, Y.F, Chen, X, Wu, Q.Q, Zhu, D.M. 登録日 2014-10-16 公開日 2015-10-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structures of CdNal from Clostridium difficile in complex with ketobutyric to be published
4TXY	Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog 分子名称: Cyclic AMP-GMP synthase, MAGNESIUM ION 著者 Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. 登録日 2014-07-07 公開日 2014-08-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.0001 Å) 主引用文献 Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
4TY0	Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG 分子名称: ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ... 著者 Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. 登録日 2014-07-07 公開日 2014-08-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
4TXZ	Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP 分子名称: Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. 登録日 2014-07-07 公開日 2014-08-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
5OAC	FLiP major capsid protein 分子名称: Major capsid protein 著者 De Colibus, L, Stuart, D.I, Huiskonen, J.T. 登録日 2017-06-21 公開日 2017-07-26 最終更新日 2019-11-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Virus found in a boreal lake links ssDNA and dsDNA viruses. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6XVB	Crystal structure of the kinase domain of human c-KIT with a cyclic imidate inhibitor covalently bound to Cys788 分子名称: Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, ~{N}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide 著者 Schimpl, M, McAuley, K, Hoyt, E.A, Thomas, M, Bodnarchuk, M.S, Lewis, H.J, Barratt, D, Deery, M.J, Ogg, D.J, Bernardes, G.J.L, Ward, R.A, Kettle, J.G, Waring, M.J. 登録日 2020-01-21 公開日 2020-05-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. J.Am.Chem.Soc., 142, 2020
6XVJ	Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor 分子名称: Vascular endothelial growth factor receptor 2, ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide 著者 Schimpl, M, McAuley, K, Hoyt, E.A, Thomas, M, Bodnarchuk, M.S, Lewis, H.J, Barratt, D, Deery, M.J, Ogg, D.J, Bernardes, G.J.L, Ward, R.A, Kettle, J.G, Waring, M.J. 登録日 2020-01-22 公開日 2020-05-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. J.Am.Chem.Soc., 142, 2020
5NP3	Abl2 SH3 分子名称: Abelson tyrosine-protein kinase 2 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
5NP5	Abl2 SH3 pTyr116/161 分子名称: Abelson tyrosine-protein kinase 2, SULFATE ION 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019

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