PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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7UZG	Rat Kidney V-ATPase lacking subunit H, with SidK and NCOA7B, State 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase H+-transporting V1 subunit A, ATPase H+-transporting V1 subunit D, ... 著者 Rubinstein, J.L, Abbas, Y.M. 登録日 2022-05-09 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of V-ATPase with NCOA7B To Be Published
5C5P	CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR 分子名称: (3R)-3-(1-hydroxy-2-methylpropan-2-yl)-1,3,4,5-tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one, SULFATE ION, Tankyrase-2, ... 著者 Lukacs, C.M, Janson, C.A. 登録日 2015-06-21 公開日 2015-08-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors. Acs Med.Chem.Lett., 6, 2015
5WDI	Structure of Human Sts-2 histidine phosphatase domain 分子名称: SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein A 著者 Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. 登録日 2017-07-05 公開日 2017-08-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry, 56, 2017
5C5R	CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR 分子名称: (7R)-2-hydroxy-7-(propan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile, SULFATE ION, Tankyrase-2, ... 著者 Lukacs, C.M, Janson, C.A. 登録日 2015-06-21 公開日 2015-08-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors. Acs Med.Chem.Lett., 6, 2015
3DT1	P38 Complexed with a quinazoline inhibitor 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 著者 Herberich, B, Syed, R, Li, V, Tasker, A.S. 登録日 2008-07-14 公開日 2008-10-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008
5WJJ	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors 分子名称: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide 著者 Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. 登録日 2017-07-23 公開日 2018-01-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
4L0S	Tankyrase 2 in complex with 4'-cyano flavone 分子名称: 4-(4-oxo-4H-chromen-2-yl)benzonitrile, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-01 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L0I	Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate 分子名称: SULFATE ION, Tankyrase-2, ZINC ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-05-31 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L10	Tankyrase 2 in complex with 4'-methoxy flavone 分子名称: 2-(4-methoxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-01 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L0T	Tankyrase 2 in complex with 4'-nitro flavone 分子名称: 2-(4-nitrophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-01 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
4L52	Crystal Structure of 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethan-1-one bound to TAK1-TAB1 分子名称: 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethanone, Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera 著者 Wang, J, Hornberger, K.R, Crew, A.P, Jestel, A, Maskos, K, Moertl, M. 登録日 2013-06-10 公開日 2013-07-03 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1. Bioorg.Med.Chem.Lett., 23, 2013
4L2G	Tankyrase 2 in complex with 6- fluoro flavone 分子名称: 6-fluoro-2-phenyl-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Narwal, M, Haikarainen, T, Lehtio, L. 登録日 2013-06-04 公開日 2013-10-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem., 56, 2013
5W7Y	Crystal Structure of FHA domain of human APLF in complex with XRCC1 monophosphorylated mutated peptide 分子名称: Aprataxin and PNK-like factor, DNA repair protein XRCC1 著者 Pedersen, L.C, Kim, K, London, R.E. 登録日 2017-06-21 公開日 2018-05-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications. Nucleic Acids Res., 45, 2017
3DVU	Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and the Beclin 1 BH3 domain 分子名称: Beclin-1, V-bcl-2 著者 Sinha, S. 登録日 2008-07-20 公開日 2008-10-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy, 4, 2008
4L68	Structure of the psedudokinase domain of BIR2, an immune regulator of the RLK/Pelle family 分子名称: 1,3-PROPANDIOL, Leucine-rich repeat protein kinase-like protein 著者 Blaum, B.S, Stehle, T. 登録日 2013-06-12 公開日 2014-03-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis. J.Struct.Biol., 186, 2014
2WYQ	THE CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE (UBL) DOMAIN OF HHR23A (HUMAN HOMOLOGUE A OF RAD23) 分子名称: SULFATE ION, UV EXCISION REPAIR PROTEIN RAD23 HOMOLOG A 著者 Chen, Y.W. 登録日 2009-11-19 公開日 2010-11-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 The Crystal Structure of the Ubiquitin-Like (Ubl) Domain of Human Homologue a of Rad23 (Hhr23A) Protein Protein Eng.Des.Sel., 24, 2011
4LI7	TANKYRASE-1 complexed with small molecule inhibitor 4-chloro-5-cyano-N-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-methoxybenzamide 分子名称: 4-chloro-5-cyano-N-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-methoxybenzamide, SODIUM ION, SULFATE ION, ... 著者 Kirby, C.A, Stams, T. 登録日 2013-07-02 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of NVP-TNKS656: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor. J.Med.Chem., 56, 2013
5X1V	PKM2 in complex with compound 2 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrole-2-carboxamide, Pyruvate kinase PKM 著者 Matsui, Y, Hanzawa, H. 登録日 2017-01-27 公開日 2017-05-31 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator Bioorg. Med. Chem., 25, 2017
6T16	ASR Alternansucrase in complex with panose 分子名称: Alternansucrase, CALCIUM ION, alpha-D-glucopyranose, ... 著者 Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M. 登録日 2019-10-03 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation. J.Biol.Chem., 295, 2020
2WJY	Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 Orthorhombic form 分子名称: REGULATOR OF NONSENSE TRANSCRIPTS 1, SULFATE ION, ZINC ION 著者 Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S. 登録日 2009-06-01 公開日 2009-07-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2. Embo J., 28, 2009
5WOS	Structural and functional insights into Canarypox Virus CNP058 regulation of apoptosis 分子名称: Bcl-2-like protein 11, CNPV058 bcl-2 like protein 著者 Anasir, M.I, Kvansakul, M. 登録日 2017-08-02 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis. Viruses, 9, 2017
6SZI	ASR Alternansucrase in complex with isomaltose 分子名称: Alternansucrase, CALCIUM ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose 著者 Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M. 登録日 2019-10-02 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation. J.Biol.Chem., 295, 2020
2X5N	Crystal Structure of the SpRpn10 VWA domain 分子名称: 26S PROTEASOME REGULATORY SUBUNIT RPN10, SULFATE ION 著者 Riedinger, C, Boehringer, J, Trempe, J.-F, Lowe, E.D, Brown, N.R, Gehring, K, Noble, M.E.M, Gordon, C, Endicott, J.A. 登録日 2010-02-10 公開日 2010-08-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12. J.Biol.Chem., 285, 2010
5AKU	Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1,2, 3,4-tetrahydroquinazolin-4-one 分子名称: 2-(4-tert-butylphenyl)-1,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Lehtio, L. 登録日 2015-03-05 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23, 2015
5YGC	Crystal structure of Drosophila melanogaster Papi extended Tudor domain 分子名称: GH18329p 著者 Zhang, Y.H, Huang, Y. 登録日 2017-09-22 公開日 2018-03-14 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into the sequence-specific recognition of Piwi byDrosophilaPapi Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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