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5C5R

CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR

Summary for 5C5R
Entry DOI10.2210/pdb5c5r/pdb
Related5C5P 5C5R
DescriptorTankyrase-2, ZINC ION, (7R)-2-hydroxy-7-(propan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile, ... (6 entities in total)
Functional Keywordswnt-signalling, beta-catenin, parp-domain, adp-ribosylation, axin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm: Q9H2K2 Q9H2K2
Total number of polymer chains4
Total formula weight55587.10
Authors
Lukacs, C.M.,Janson, C.A. (deposition date: 2015-06-21, release date: 2015-08-12, Last modification date: 2023-09-27)
Primary citationde Vicente, J.,Tivitmahaisoon, P.,Berry, P.,Bolin, D.R.,Carvajal, D.,He, W.,Huang, K.S.,Janson, C.,Liang, L.,Lukacs, C.,Petersen, A.,Qian, H.,Yi, L.,Zhuang, Y.,Hermann, J.C.
Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.
Acs Med.Chem.Lett., 6:1019-1024, 2015
Cited by
PubMed: 26396691
DOI: 10.1021/acsmedchemlett.5b00251
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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