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5C5R

CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
B0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
C0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
D0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 1201
ChainResidue
ACYS1081
AHIS1084
ACYS1089
ACYS1092

site_idAC2
Number of Residues12
Detailsbinding site for residue 0E1 A 1202
ChainResidue
APHE1061
AALA1062
ALYS1067
ASER1068
ATYR1071
AHOH1403
CHOH1302
AHIS1031
AGLY1032
AALA1049
ATYR1050
ATYR1060

site_idAC3
Number of Residues8
Detailsbinding site for residue SO4 A 1203
ChainResidue
AARG977
AHIS979
AARG980
ALYS1067
AGLN1070
AHOH1379
CHOH1314
CHOH1317

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 C 1201
ChainResidue
AASN990
AARG991
AHOH1355
CPRO1160
CGLU1161

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN B 1201
ChainResidue
BCYS1081
BHIS1084
BCYS1089
BCYS1092

site_idAC6
Number of Residues11
Detailsbinding site for residue 0E1 B 1202
ChainResidue
BHIS1031
BGLY1032
BTYR1050
BTYR1060
BPHE1061
BALA1062
BLYS1067
BSER1068
BTYR1071
BHOH1427
DHOH1307

site_idAC7
Number of Residues8
Detailsbinding site for residue SO4 B 1203
ChainResidue
BARG977
BHIS979
BARG980
BLYS1067
BHOH1356
BHOH1449
DHOH1305
DHOH1308

site_idAC8
Number of Residues6
Detailsbinding site for residue SO4 D 1201
ChainResidue
BASN990
BARG991
DPRO1160
DGLU1161
DHOH1306
DHOH1311

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O95271
ChainResidueDetails
ACYS1081
AHIS1084
ACYS1089
ACYS1092
BCYS1081
BHIS1084
BCYS1089
BCYS1092

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PDB entries from 2024-10-30

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