5X1V

PKM2 in complex with compound 2

Summary for 5X1V

• Entry DOI: 10.2210/pdb5x1v/pdb
• Related: 5X1W
• Descriptor: Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrole-2-carboxamide, ... (4 entities in total)
• Functional Keywords: activator, complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 242749.42

Authors

Matsui, Y.,Hanzawa, H. (deposition date: 2017-01-27, release date: 2017-05-31, Last modification date: 2024-04-03)

• Primary citation: Matsui, Y.,Yasumatsu, I.,Asahi, T.,Kitamura, T.,Kanai, K.,Ubukata, O.,Hayasaka, H.,Takaishi, S.,Hanzawa, H.,Katakura, S.; Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator; Bioorg. Med. Chem., 25:3540-3546, 2017; PubMed: 28511909; DOI: 10.1016/j.bmc.2017.05.004

Experimental method

X-RAY DIFFRACTION (2.1 Å)