5AKU

Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1,2, 3,4-tetrahydroquinazolin-4-one

Summary for 5AKU

Entry DOI	10.2210/pdb5aku/pdb
Related	5AKW 5AL1 5AL2 5AL3 5AL4 5AL5
Descriptor	TANKYRASE-2, SULFATE ION, 2-(4-tert-butylphenyl)-1,4-dihydroquinazolin-4-one, ... (6 entities in total)
Functional Keywords	transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	2
Total formula weight	56039.67
Authors	Nkizinkiko, Y.,Lehtio, L. (deposition date: 2015-03-05, release date: 2015-07-29, Last modification date: 2024-01-10)
Primary citation	Nkizinkiko, Y.,Suneel Kumar, B.V.S.,Jeankumar, V.U.,Haikarainen, T.,Koivunen, J.,Madhuri, C.,Yogeeswari, P.,Venkannagari, H.,Obaji, E.,Pihlajaniemi, T.,Sriram, D.,Lehtio, L. Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23:4139-, 2015 Cited by PubMed: 26183543 DOI: 10.1016/J.BMC.2015.06.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation