5AKW
Crystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-one
Summary for 5AKW
Entry DOI | 10.2210/pdb5akw/pdb |
Related | 5AKU |
Descriptor | TANKYRASE-2, ZINC ION, (2S)-2-(4-chlorophenyl)-2,3-dihydro-1H-quinazolin-4-one, ... (6 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 55724.10 |
Authors | Nkizinkiko, Y.,Lehtio, L. (deposition date: 2015-03-05, release date: 2015-07-29, Last modification date: 2024-01-10) |
Primary citation | Nkizinkiko, Y.,Suneel Kumar, B.V.S.,Jeankumar, V.U.,Haikarainen, T.,Koivunen, J.,Madhuri, C.,Yogeeswari, P.,Venkannagari, H.,Obaji, E.,Pihlajaniemi, T.,Sriram, D.,Lehtio, L. Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Bioorg.Med.Chem., 23:4139-, 2015 Cited by PubMed: 26183543DOI: 10.1016/J.BMC.2015.06.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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