5C5P

CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR

Summary for 5C5P

• Entry DOI: 10.2210/pdb5c5p/pdb
• Related: 3KR8 5C5Q 5C5R
• Descriptor: Tankyrase-2, ZINC ION, (3R)-3-(1-hydroxy-2-methylpropan-2-yl)-1,3,4,5-tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one, ... (6 entities in total)
• Functional Keywords: wnt-signalling, beta-catenin, parp-domain, adp-ribosylation, axin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: Q9H2K2 Q9H2K2
• Total number of polymer chains: 4
• Total formula weight: 55697.25

Authors

Lukacs, C.M.,Janson, C.A. (deposition date: 2015-06-21, release date: 2015-08-12, Last modification date: 2023-09-27)

• Primary citation: de Vicente, J.,Tivitmahaisoon, P.,Berry, P.,Bolin, D.R.,Carvajal, D.,He, W.,Huang, K.S.,Janson, C.,Liang, L.,Lukacs, C.,Petersen, A.,Qian, H.,Yi, L.,Zhuang, Y.,Hermann, J.C.; Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors.; Acs Med.Chem.Lett., 6:1019-1024, 2015; PubMed: 26396691; DOI: 10.1021/acsmedchemlett.5b00251

Experimental method

X-RAY DIFFRACTION (1.75 Å)