5C5P
CRYSTAL STRUCTURE OF HUMAN TANKYRASE-2 IN COMPLEX WITH A PYRANOPYRIDONE INHIBITOR
Summary for 5C5P
Entry DOI | 10.2210/pdb5c5p/pdb |
Related | 3KR8 5C5Q 5C5R |
Descriptor | Tankyrase-2, ZINC ION, (3R)-3-(1-hydroxy-2-methylpropan-2-yl)-1,3,4,5-tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one, ... (6 entities in total) |
Functional Keywords | wnt-signalling, beta-catenin, parp-domain, adp-ribosylation, axin, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q9H2K2 Q9H2K2 |
Total number of polymer chains | 4 |
Total formula weight | 55697.25 |
Authors | Lukacs, C.M.,Janson, C.A. (deposition date: 2015-06-21, release date: 2015-08-12, Last modification date: 2023-09-27) |
Primary citation | de Vicente, J.,Tivitmahaisoon, P.,Berry, P.,Bolin, D.R.,Carvajal, D.,He, W.,Huang, K.S.,Janson, C.,Liang, L.,Lukacs, C.,Petersen, A.,Qian, H.,Yi, L.,Zhuang, Y.,Hermann, J.C. Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors. Acs Med.Chem.Lett., 6:1019-1024, 2015 Cited by PubMed: 26396691DOI: 10.1021/acsmedchemlett.5b00251 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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