PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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4KYD	Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP. 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Maltose-binding periplasmic protein, Phosphoprotein, ... 著者 Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. 登録日 2013-05-28 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Protein domain definition should allow for conditional disorder. Protein Sci., 22, 2013
4KYC	Structure of the C-terminal domain of the Menangle virus phosphoprotein, fused to MBP. 分子名称: 1,2-ETHANEDIOL, BORIC ACID, Maltose-binding periplasmic protein, ... 著者 Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. 登録日 2013-05-28 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Protein domain definition should allow for conditional disorder. Protein Sci., 22, 2013
4CNI	Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 分子名称: INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ... 著者 Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A. 登録日 2014-01-22 公開日 2014-04-30 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling. Mabs, 6, 2014
4KYE	Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP. 分子名称: Maltose-binding periplasmic protein, Phosphoprotein, chimeric construct, ... 著者 Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. 登録日 2013-05-28 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Protein domain definition should allow for conditional disorder. Protein Sci., 22, 2013
2GF5	Structure of intact FADD (MORT1) 分子名称: FADD protein 著者 Carrington, P.E, Sandu, C, Wei, Y, Hill, J.M, Morisawa, G, Huang, T, Gavathiotis, E, Wei, Y, Werner, M.H. 登録日 2006-03-21 公開日 2006-06-27 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The Structure of FADD and Its Mode of Interaction with Procaspase-8 Mol.Cell, 22, 2006
2GAT	SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF CHICKEN GATA-1 BOUND TO DNA, NMR, REGULARIZED MEAN STRUCTURE 分子名称: DNA (5'-D(*AP*AP*TP*GP*TP*TP*TP*AP*TP*CP*TP*GP*CP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*GP*CP*AP*GP*AP*TP*AP*AP*AP*CP*AP*TP*T)-3'), ERYTHROID TRANSCRIPTION FACTOR GATA-1, ... 著者 Clore, G.M, Tjandra, N, Starich, M, Omichinski, J.G, Gronenborn, A.M. 登録日 1997-11-07 公開日 1998-01-28 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Use of dipolar 1H-15N and 1H-13C couplings in the structure determination of magnetically oriented macromolecules in solution. Nat.Struct.Biol., 4, 1997
1CDW	HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA 分子名称: DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)) 著者 Nikolov, D.B, Chen, H, Halay, E.D, Hoffmann, A, Roeder, R.G, Burley, S.K. 登録日 1996-04-11 公開日 1996-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of a human TATA box-binding protein/TATA element complex. Proc.Natl.Acad.Sci.USA, 93, 1996
2GVL	Crystal Structure of Murine NMPRTase 分子名称: Nicotinamide phosphoribosyltransferase 著者 Khan, J.A, Tao, X, Tong, L. 登録日 2006-05-02 公開日 2006-07-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13, 2006
2H3B	Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1 分子名称: Nicotinamide phosphoribosyltransferase, SULFATE ION 著者 Wang, T, Zhang, X, Bheda, P, Revollo, J.R, Imai, S.I, Wolberger, C. 登録日 2006-05-22 公開日 2006-06-20 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme. Nat.Struct.Mol.Biol., 13, 2006
2HAJ	Solution structure of the helicase-binding domain of Escherichia coli primase 分子名称: DNA primase 著者 Su, X.C, Loscha, K.V, Dixon, N.E, Otting, G. 登録日 2006-06-13 公開日 2006-10-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase Febs J., 273, 2006
2GVJ	Crystal Structure of Human NMPRTase in complex with FK866 分子名称: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase 著者 Khan, J.A, Tao, X, Tong, L. 登録日 2006-05-02 公開日 2006-06-20 最終更新日 2016-11-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13, 2006
2H1K	Crystal structure of the Pdx1 homeodomain in complex with DNA 分子名称: 15-mer DNA, Pancreatic and duodenal homeobox 1 著者 Longo, A, Guanga, G.P, Rose, R.B. 登録日 2006-05-16 公開日 2007-03-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural basis for induced fit mechanisms in DNA recognition by the pdx1 homeodomain Biochemistry, 46, 2007
2GVG	Crystal Structure of human NMPRTase and its complex with NMN 分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Khan, J.A, Tao, X, Tong, L. 登録日 2006-05-02 公開日 2006-06-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13, 2006
4L4M	Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase 分子名称: 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-7-carboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Oh, A, Ho, Y, Zak, M, Liu, Y, Yuen, P, Zheng, X, Dragovich, S.P, Wang, W. 登録日 2013-06-08 公開日 2014-06-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.445 Å) 主引用文献 Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
1PXM	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol 分子名称: 3-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL, Cell division protein kinase 2 著者 Wang, S, Meades, C, Wood, G, Osnowski, A, Anderson, S, Yuill, R, Thomas, M, Jackson, W, Midgley, C, Griffiths, G, McNae, I, Wu, S.Y, McInnes, C, Zheleva, D, Walkinshaw, M.D, Fischer, P.M. 登録日 2003-07-04 公開日 2004-04-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. J.Med.Chem., 47, 2004
4LVG	Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 分子名称: (1S,2S)-N-[4-(phenylsulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropanecarboxamide, 1,2-ETHANEDIOL, Nicotinamide phosphoribosyltransferase, ... 著者 Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. 登録日 2013-07-26 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4M6P	Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 分子名称: N-[4-(phenylsulfonyl)benzyl]-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. 登録日 2013-08-10 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
4MHG	Crystal structure of ETV6 bound to a specific DNA sequence 分子名称: Complementary Specific 14 bp DNA, Specific 14 bp DNA, Transcription factor ETV6 著者 Chan, A.C, De, S, Coyne III, H.J, Okon, M, Murphy, M.E, Graves, B.J, McIntosh, L.P. 登録日 2013-08-29 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
4M6Q	Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 分子名称: 1-(5-O-phosphono-beta-D-ribofuranosyl)-N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, ... 著者 Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. 登録日 2013-08-10 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
2HWV	Crystal structure of an essential response regulator DNA binding domain, VicRc in Enterococcus faecalis, a member of the YycF subfamily. 分子名称: DNA-binding response regulator VicR, SULFATE ION 著者 Trinh, C.H, Liu, Y, Phillips, S.E.V, Phillips-Jones, M.K. 登録日 2006-08-02 公開日 2007-01-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the response regulator VicR DNA-binding domain. Acta Crystallogr.,Sect.D, 63, 2007
4LTS	Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors 分子名称: 1,2-ETHANEDIOL, 2-cyano-1-pyridin-4-yl-3-(4-{[3-(trifluoromethoxy)phenyl]sulfonyl}benzyl)guanidine, Nicotinamide phosphoribosyltransferase, ... 著者 Zheng, X, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynoids, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Oh, A, Wang, W, Zak, M, Wang, L, Yuen, P, Bair, K.W. 登録日 2013-07-23 公開日 2013-12-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.692 Å) 主引用文献 Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
4LVB	Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) 分子名称: 1,2-ETHANEDIOL, N-[4-(acetylamino)phenyl]cyclopropanecarboxamide, Nicotinamide phosphoribosyltransferase, ... 著者 Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. 登録日 2013-07-26 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.836 Å) 主引用文献 Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
2I99	Crystal structure of human Mu_crystallin at 2.6 Angstrom 分子名称: Mu-crystallin homolog, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cheng, Z, Sun, L, He, J, Gong, W. 登録日 2006-09-05 公開日 2007-02-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of human {micro}-crystallin complexed with NADPH Protein Sci., 16, 2007
1PXN	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol 分子名称: 4-[4-(4-METHYL-2-METHYLAMINO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-PHENOL, Cell division protein kinase 2 著者 Wang, S, Meades, C, Wood, G, Osnowski, A, Anderson, S, Yuill, R, Thomas, M, Mezna, M, Jackson, W, Midgley, C, Griffiths, G, McNae, I, Wu, S.Y, McInnes, C, Zheleva, D, Walkinshaw, M.D, Fischer, P.M. 登録日 2003-07-04 公開日 2004-04-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. J.Med.Chem., 47, 2004
1PXP	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine 分子名称: Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE 著者 Wang, S, Meades, C, Wood, G, Osnowski, A, Anderson, S, Yuill, R, Thomas, M, Mezna, M, Jackson, W, Midgley, C, Griffiths, G, McNae, I, Wu, S.Y, McInnes, C, Zheleva, D, Walkinshaw, M.D, Fischer, P.M. 登録日 2003-07-04 公開日 2004-04-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. J.Med.Chem., 47, 2004

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