PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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4Z6E	Structure of human DNA polymerase beta 279NA mutant complexed with G in the template base paired with incoming non-hydrolyzable TTP and MANGANESE 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2015-04-04 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.752 Å) 主引用文献 Insights into the effect of minor groove interactions and metal cofactors on mutagenic replication by human DNA polymerase beta. Biochem. J., 475, 2018
7AN7	Enzyme of biosynthetic pathway 分子名称: 3-[(1-Carboxyvinyl)oxy]benzoic acid, Chorismate dehydratase, GLYCEROL 著者 Archna, A, Breithaupt, C, Stubbs, M.T. 登録日 2020-10-11 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis J.Biol.Chem., 2022
7AN8	Enzyme of biosynthetic pathway 分子名称: 3-[(1-Carboxyvinyl)oxy]benzoic acid, Chorismate dehydratase, GLYCEROL 著者 Archna, A, Breithaupt, C, Stubbs, M.T. 登録日 2020-10-11 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis J.Biol.Chem., 2022
7AN9	Enzyme of biosynthetic pathway 分子名称: 3-[(1-Carboxyvinyl)oxy]benzoic acid, Chorismate dehydratase 著者 Archna, A, Breithaupt, C, Stubbs, M.T. 登録日 2020-10-11 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Mechanism of the chorismate dehydratase MqnA, first enzyme of the futalosine pathway Chemrxiv, 2022
7B1T	Crystal structure of BRD4(1) in complex with the inhibitor MPM6 分子名称: 3-(5-azanyl-2-chloranyl-phenyl)-1-methyl-4,7-dihydro-2~{H}-cyclohepta[c]pyrrol-8-one, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE 著者 Huegle, M. 登録日 2020-11-25 公開日 2022-06-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 A novel pan-selective bromodomain inhibitor for epigenetic drug design. Eur.J.Med.Chem., 249, 2023
4YAW	Reduced CYPOR mutant - G141del 分子名称: ADENOSINE-2'-MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Xia, C, Kim, J.J.P. 登録日 2015-02-17 公開日 2016-03-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
5E6E	Crystal Structure of Carbonmonoxy Sickle Hemoglobin in R-State Conformation 分子名称: CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Safo, M.K, Ahmed, M.H. 登録日 2015-10-09 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation. J.Struct.Biol., 194, 2016
6BOS	Human APE1 substrate complex with an A/C mismatch adjacent the THF 分子名称: 21-mer DNA, DNA-(apurinic or apyrimidinic site) lyase 著者 Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. 登録日 2017-11-20 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
5FF6	Cetuximab Fab in complex with L10Q meditope variant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... 著者 Bzymek, K.P, Williams, J.C. 登録日 2015-12-17 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
6BVE	Triosephosphate isomerase of Synechocystis in complex with 2-Phosphoglycolic acid 分子名称: 2-PHOSPHOGLYCOLIC ACID, SODIUM ION, Triosephosphate isomerase 著者 Jimenez-Sandoval, P, Castro-Torres, E, Brieba, L.G. 登録日 2017-12-12 公開日 2018-12-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Basis for the Limited Response to Oxidative and Thiol-Conjugating Agents by Triosephosphate Isomerase From the Photosynthetic BacteriaSynechocystis. Front Mol Biosci, 5, 2018
7A12	CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR GW557358X (COMPOUND 9) 分子名称: 5-chloranyl-3-phenyl-1~{H}-indole-2-carboxamide, MANGANESE (II) ION, Methionine aminopeptidase 2, ... 著者 Thorpe, J.H. 登録日 2020-08-11 公開日 2020-09-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'. Bioorg.Med.Chem.Lett., 30, 2020
7ACH	CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 分子名称: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... 著者 Kessler, D. 登録日 2020-09-10 公開日 2020-11-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 To Be Published
4YAU	Reduced CYPOR mutant - G141del/E142N 分子名称: ADENOSINE-2'-MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Xia, C, Kim, J.J.P. 登録日 2015-02-17 公開日 2016-03-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
6BMB	Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate 分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ... 著者 Christendat, D, Peek, J. 登録日 2017-11-14 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.077 Å) 主引用文献 Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases. Plant J., 2018
4YFJ	Crystal structure of aminoglycoside acetyltransferase AAC(3)-Ib 分子名称: Aminoglycoside 3'-N-acetyltransferase, SULFATE ION 著者 Stogios, P.J, Xu, Z, Evdokimova, E, Yim, V, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2015-02-25 公開日 2015-03-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of aminoglycoside acetyltransferase AAC(3)-Ib To Be Published
6BIQ	Structure of NlpC2 from Trichomonas vaginalis 分子名称: Clan CA, family C40, NlpC/P60 superfamily cysteine peptidase 著者 Pinheiro, J, Simoes-Barbosa, A, Goldstone, D.C. 登録日 2017-11-02 公開日 2018-11-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The ProtozoanTrichomonas vaginalisTargets Bacteria with Laterally Acquired NlpC/P60 Peptidoglycan Hydrolases. Mbio, 9, 2018
6BMQ	Crystal structure of Arabidopsis Dehydroquinate dehydratase-shikimate dehydrogenase (T381G mutant) in complex with tartrate and shikimate 分子名称: (1S,3R,4S,5R)-1,3,4,5-tetrahydroxycyclohexanecarboxylic acid, Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic, ... 著者 Christendat, D, Peek, J. 登録日 2017-11-15 公開日 2018-09-26 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.077 Å) 主引用文献 Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases. Plant J., 2018
7BHO	DNA origami signpost designed model 分子名称: DNA, DNA scaffold 著者 Silvester, E, Vollmer, B, Prazak, V, Vasishtan, D, Machala, E.A, Whittle, C, Black, S, Bath, J, Turberfield, A.J, Gruenewald, K, Baker, L.A. 登録日 2021-01-11 公開日 2021-04-14 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (36.439999 Å) 主引用文献 DNA origami signposts for identifying proteins on cell membranes by electron cryotomography. Cell, 184, 2021
5F49	Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with malonyl-coenzyme A 分子名称: COENZYME A, MAGNESIUM ION, MALONYL-COENZYME A, ... 著者 Xu, Z, Skarina, T, Stogios, P.J, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2015-12-03 公開日 2015-12-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes. ACS Infect Dis, 3, 2017
6BJR	Crystal structure of prothrombin mutant S101C/A470C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... 著者 Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. 登録日 2017-11-06 公開日 2018-06-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
7BJ3	ScpA from Streptococcus pyogenes, S512A active site mutant 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, C5a peptidase, CALCIUM ION, ... 著者 Kagawa, T.F, O'Connell, M.R, Cooney, J.C. 登録日 2021-01-13 公開日 2021-05-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. Comput Struct Biotechnol J, 19, 2021
5ETU	Cetuximab Fab in complex with L5E meditope variant 分子名称: Cetuximab Fab heavy chain, Cetuximab Fab light chain, L5E meditope variant, ... 著者 Bzymek, K.P, Williams, J.C. 登録日 2015-11-18 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
4YAO	Reduced CYPOR mutant - G143del 分子名称: ADENOSINE-2'-MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Xia, C, Kim, J.J.P. 登録日 2015-02-17 公開日 2016-03-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. J.Biol.Chem., 291, 2016
7BGQ	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1019 分子名称: 14-3-3 protein sigma, 2-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
5F6W	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) 分子名称: 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 著者 Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. 登録日 2015-12-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016

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