7B1T

Crystal structure of BRD4(1) in complex with the inhibitor MPM6

Summary for 7B1T

Entry DOI	10.2210/pdb7b1t/pdb
Descriptor	Bromodomain-containing protein 4, 3-(5-azanyl-2-chloranyl-phenyl)-1-methyl-4,7-dihydro-2~{H}-cyclohepta[c]pyrrol-8-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	brd4, brd4(1), bet, mpm6, bromodomain, inhibitor, co-crystal, cocrystal, fragment, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15542.40
Authors	Huegle, M. (deposition date: 2020-11-25, release date: 2022-06-08, Last modification date: 2024-02-07)
Primary citation	Warstat, R.,Pervaiz, M.,Regenass, P.,Amann, M.,Schmidtkunz, K.,Einsle, O.,Jung, M.,Breit, B.,Hugle, M.,Gunther, S. A novel pan-selective bromodomain inhibitor for epigenetic drug design. Eur.J.Med.Chem., 249:115139-115139, 2023 Cited by PubMed: 36736153 DOI: 10.1016/j.ejmech.2023.115139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation