PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

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5BZU	Crystal structure of the RNA-binding domain of yeast Puf5p bound to AAT2 RNA 分子名称: Suppressor protein MPT5, UGUAAUA 著者 Qiu, C, Hall, T.M.T. 登録日 2015-06-11 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 RNA regulatory networks diversified through curvature of the PUF protein scaffold. Nat Commun, 6, 2015
5DFP	Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036 分子名称: 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, DIMETHYL SULFOXIDE, Serine/threonine-protein kinase PAK 1 著者 Maksimoska, J, Marmorstein, R, Wang, W. 登録日 2015-08-27 公開日 2016-01-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. Acs Med.Chem.Lett., 6, 2015
5DG0	Human APE1 phosphorothioate substrate complex with Mn2+ 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(OMC)P*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... 著者 Freudenthal, B.D, Wilson, S.H. 登録日 2015-08-27 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
7BVZ	Crystal structure of MreB5 of Spiroplasma citri bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell shape determining protein MreB, MAGNESIUM ION, ... 著者 Pande, V, Bagde, S.R, Gayathri, P. 登録日 2020-04-12 公開日 2020-10-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 MreB5 Is a Determinant of Rod-to-Helical Transition in the Cell-Wall-less Bacterium Spiroplasma. Curr.Biol., 30, 2020
4XV0	Crystal structure of an endo-beta-1,4-xylanase (glycoside hydrolase family 10/GH10) enzyme from Trichoderma reesei 分子名称: Beta-xylanase, CHLORIDE ION, GLYCEROL, ... 著者 Stogios, P.J, Xu, X, Cui, H, Savchenko, A. 登録日 2015-01-26 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9697 Å) 主引用文献 Crystal structure of an endo-beta-1,4-xylanase (glycoside hydrolase family 10/GH10) enzyme from Trichoderma reesei To Be Published
4XHM	Archaeoglobus fulgidus thioredoxin 3 M60H 分子名称: Thioredoxin (Trx-3) 著者 Dey, M, Bjork, R.E, Drennan, C.L. 登録日 2015-01-05 公開日 2015-04-29 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rheostat Re-Wired: Alternative Hypotheses for the Control of Thioredoxin Reduction Potentials. Plos One, 10
7A14	CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR GSK2218325A (COMPOUND 32) 分子名称: 5-chloranyl-6-fluoranyl-3-(2-propan-2-yloxyphenyl)-1~{H}-indole-2-carboxamide, MANGANESE (II) ION, Methionine aminopeptidase 2, ... 著者 Thorpe, J.H. 登録日 2020-08-11 公開日 2020-09-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'. Bioorg.Med.Chem.Lett., 30, 2020
4Y23	Crystal structure of T399A precursor mutant protein of gamma-glutamyl transpeptidase from Bacillus licheniformis 分子名称: Gamma glutamyl transpeptidase,Gamma-glutamyltranspeptidase, SODIUM ION 著者 Pica, A, Merlino, A. 登録日 2015-02-09 公開日 2015-11-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 The maturation mechanism of gamma-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies. Biochim.Biophys.Acta, 1864, 2015
5DFI	Human APE1 phosphorothioate substrate complex 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(OMC)P*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... 著者 Freudenthal, B.D, Wilson, S.H. 登録日 2015-08-26 公開日 2015-10-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Capturing snapshots of APE1 processing DNA damage. Nat.Struct.Mol.Biol., 22, 2015
8AGA	Structure of p-hydroxy benzoic acid ligand bound HosA transcriptional regulator from enteropathogenic Escherichia coli O127:H6 (strain E2348/69) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, P-HYDROXYBENZOIC ACID, ... 著者 Goswami, A, Kannika, B.R, Madan Kumar, S. 登録日 2022-07-19 公開日 2023-08-02 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Horizontally acquired HosA transcription factor bound with 4-hydroxy-benzoic acid exhibits unique tug-of-water dynamics Biorxiv, 2024
4XXO	Crystal Structure of Human APOBEC3A 分子名称: CHLORIDE ION, DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION 著者 Bohn, M.F, Shandilya, S.M.D, Schiffer, C.A. 登録日 2015-01-30 公開日 2015-04-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.843 Å) 主引用文献 The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure, 23, 2015
5EC9	Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2 分子名称: 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha 著者 Leysen, S, Ottmann, C, Schafer, A, Scheepstra, M, Brunsveld, L, Sunden, R, Ma, J.N, Burnstein, E.S, Olsson, R. 登録日 2015-10-20 公開日 2016-03-09 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. J.Med.Chem., 59, 2016
4XDW	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH 分子名称: Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-20 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
6BIM	Structure of NlpC1 from Trichomonas vaginalis 分子名称: Clan CA, family C40, NlpC/P60 superfamily cysteine peptidase 著者 Pinheiro, J, Simoes-Barbosa, A, Goldstone, D.C. 登録日 2017-11-02 公開日 2018-11-07 最終更新日 2019-05-29 実験手法 X-RAY DIFFRACTION (1.547 Å) 主引用文献 The ProtozoanTrichomonas vaginalisTargets Bacteria with Laterally Acquired NlpC/P60 Peptidoglycan Hydrolases. Mbio, 9, 2018
6ZSQ	Crystal structure of the Cisplatin beta-Lactoglobulin adduct formed after 18 h of soaking 分子名称: AMMONIA, Beta-lactoglobulin, PLATINUM (II) ION, ... 著者 Balasco, N, Ferraro, G, Merlino, A. 登録日 2020-07-16 公開日 2020-09-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.004 Å) 主引用文献 Cisplatin binding to beta-lactoglobulin: a structural study. Dalton Trans, 49, 2020
6ZSR	Crystal structure of the Cisplatin beta-Lactoglobulin adduct formed after 72 h of soaking 分子名称: AMMONIA, Beta-lactoglobulin, PLATINUM (II) ION, ... 著者 Balasco, N, Ferraro, G, Merlino, A. 登録日 2020-07-16 公開日 2020-09-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 Cisplatin binding to beta-lactoglobulin: a structural study. Dalton Trans, 49, 2020
4Y1L	Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation 分子名称: RWD domain-containing protein 3, SUMO-conjugating enzyme UBC9 著者 Aileen, Y.A, Ambaye, N.D, Li, Y.J, Vega, R, Bzymek, K, Williams, J.C, Hu, W, Chen, Y. 登録日 2015-02-08 公開日 2015-05-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 RWD Domain as an E2 (Ubc9)-Interaction Module. J.Biol.Chem., 290, 2015
4XJA	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Brear, P. 登録日 2015-01-08 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
6BNR	Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310) 分子名称: 2-[(4-methoxy-2-methylphenoxy)methyl]pyridine, CARBON MONOXIDE, Hemoglobin subunit alpha, ... 著者 Pagare, P.P, Musayev, F.N, Safo, M.K. 登録日 2017-11-17 公開日 2018-09-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease. Bioorg. Med. Chem., 26, 2018
4Y3B	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma 分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C 著者 Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. 登録日 2015-02-10 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4XJV	Crystal structure of human thioesterase 2 分子名称: CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain 著者 Ritchie, M.K, Kridel, S.J, Lowther, W.T. 登録日 2015-01-09 公開日 2015-12-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J.Biol.Chem., 291, 2016
4XIL	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with MPD as the cryoprotectant 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, Sialidase B 著者 Brear, P. 登録日 2015-01-07 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
6BOT	Human APE1 substrate complex with an C/C mismatch adjacent the THF 分子名称: 1,2-ETHANEDIOL, 21-mer DNA, DNA-(apurinic or apyrimidinic site) lyase 著者 Freudenthal, B.D, Whitaker, A.M, Fairlamb, M.S. 登録日 2017-11-20 公開日 2018-08-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallogr D Struct Biol, 74, 2018
4XM6	Anthrax toxin lethal factor with ligand-induced binding pocket 分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... 著者 Maize, K.M, De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-14 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.352 Å) 主引用文献 Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
4XMA	Crystal structure of the K499G mutant of NanB sialidase from streptococcus pneumoniae in complex with Optactin 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B 著者 Brear, P. 登録日 2015-01-14 公開日 2016-02-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published

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