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6BNR

Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310)

Summary for 6BNR
Entry DOI10.2210/pdb6bnr/pdb
DescriptorHemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
Functional Keywordshemoglobin, aromatic aldehyde, antisickling, allosteric effector, alpha-cleft, oxygen transport
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight65117.64
Authors
Pagare, P.P.,Musayev, F.N.,Safo, M.K. (deposition date: 2017-11-17, release date: 2018-09-05, Last modification date: 2023-10-04)
Primary citationPagare, P.P.,Ghatge, M.S.,Musayev, F.N.,Deshpande, T.M.,Chen, Q.,Braxton, C.,Kim, S.,Venitz, J.,Zhang, Y.,Abdulmalik, O.,Safo, M.K.
Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
Bioorg. Med. Chem., 26:2530-2538, 2018
Cited by
PubMed: 29655608
DOI: 10.1016/j.bmc.2018.04.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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