7XJ0
 
 | | Structure of human TRPV3 in complex with Trpvicin | | 分子名称: | Fusion protein of Transient receptor potential cation channel subfamily V member 3 and 3C-GFP, N-[5-[2-(2-cyanopropan-2-yl)pyridin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-yl]-4,6-dimethoxy-pyrimidine-5-carboxamide, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | | 登録日 | 2022-04-14 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist.
Nat.Chem.Biol., 19, 2023
|
|
6SVP
 | | Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GlcNAc | | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ... | | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | | 登録日 | 2019-09-18 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.531 Å) | | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
|
|
5DPI
 | | sfGFP double mutant - 133/149 p-cyano-L-phenylalanine | | 分子名称: | Green fluorescent protein | | 著者 | Dippel, A.B, Olenginski, G.M, Maurici, N, Liskov, M.T, Brewer, S.H, Phillips-Piro, C.M. | | 登録日 | 2015-09-12 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Probing the effectiveness of spectroscopic reporter unnatural amino acids: a structural study.
Acta Crystallogr D Struct Biol, 72, 2016
|
|
8G60
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
|
|
6HWP
 | |
10MH
 | | TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET | | 分子名称: | DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ... | | 著者 | Sheikhnejad, G, Brank, A, Christman, J.K, Goddard, A, Alvarez, E, Ford Junior, H, Marquez, V.E, Marasco, C.J, Sufrin, J.R, O'Gara, M, Cheng, X. | | 登録日 | 1998-08-10 | | 公開日 | 1999-02-09 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
|
|
6TH6
 | | Cryo-EM Structure of T. kodakarensis 70S ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | | 登録日 | 2019-11-18 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
|
|
6HAM
 | | Adenylate kinase | | 分子名称: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | | 著者 | Kantaev, R, Inbal, R, Goldenzweig, A, Barak, Y, Dym, O, Peleg, Y, Albek, S, Fleishman, S.J, Haran, G. | | 登録日 | 2018-08-08 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Manipulating the Folding Landscape of a Multidomain Protein.
J.Phys.Chem.B, 122, 2018
|
|
8X94
 | |
4LW5
 | | Crystal structure of all-trans green fluorescent protein | | 分子名称: | Green fluorescent protein | | 著者 | Rosenman, D.J, Huang, Y.-M, Xia, K, Vanroey, P, Colon, W, Bystroff, C. | | 登録日 | 2013-07-26 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Green-lighting green fluorescent protein: Faster and more efficient folding by eliminating a cis-trans peptide isomerization event.
Protein Sci., 23, 2014
|
|
8EYV
 | | Structure of Beetroot dimer bound to DFHO | | 分子名称: | (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, POTASSIUM ION, RNA (45-MER) | | 著者 | Passalacqua, L.F.M, Ferre-D'Amare, A.R. | | 登録日 | 2022-10-28 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture.
Nat Commun, 14, 2023
|
|
4FL6
 | | Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215 | | 分子名称: | Lethal(3)malignant brain tumor-like protein 3, UNKNOWN ATOM OR ION, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone} | | 著者 | Zhong, N, Tempel, W, Ravichandran, M, Dong, A, Ingerman, L.A, Graslund, S, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-06-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Nat. Chem. Biol., 9, 2013
|
|
7Q08
 | | Structure of Candida albicans 80S ribosome in complex with cycloheximide | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | | 登録日 | 2021-10-14 | | 公開日 | 2022-05-25 | | 最終更新日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
|
|
6U95
 | | Adeno-associated virus strain AAVhu.37 capsid icosahedral structure | | 分子名称: | Capsid protein VP1 | | 著者 | Kaelber, J.T, Yost, S.A, Firlar, E, Mercer, A.C. | | 登録日 | 2019-09-06 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | Structure of the AAVhu.37 capsid by cryoelectron microscopy.
Acta Crystallogr.,Sect.F, 76, 2020
|
|
8CG8
 | | Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | 登録日 | 2023-02-03 | | 公開日 | 2023-09-20 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
|
|
7OY5
 | | Crystal structure of GSK3Beta in complex with ARN25068 | | 分子名称: | CHLORIDE ION, Glycogen synthase kinase-3 beta, ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine | | 著者 | Tripathi, S.K, Balboni, B, Demuro, S, DiMartino, R, Giabbai, B, Storici, P, Ortega, J, Girotto, S, Cavalli, A. | | 登録日 | 2021-06-23 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | ARN25068, a versatile starting point towards triple GSK-3 beta /FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Eur.J.Med.Chem., 229, 2022
|
|
8IFE
 | | Arbekacin-added human 80S ribosome | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | | 登録日 | 2023-02-17 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.
J.Biochem., 175, 2024
|
|
5XV3
 | | Crystal structure of ATG101-ATG13HORMA | | 分子名称: | Autophagy-related protein 101, Autophagy-related protein 13, DI(HYDROXYETHYL)ETHER | | 著者 | Kim, B.-W, Song, H.K. | | 登録日 | 2017-06-26 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.
Autophagy, 14, 2018
|
|
6R4I
 | | Crystal structure of human GFAT-1 G461E | | 分子名称: | GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | | 著者 | Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S. | | 登録日 | 2019-03-22 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | | 主引用文献 | Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
|
|
8IFD
 | | Dibekacin-added human 80S ribosome | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | | 登録日 | 2023-02-17 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside.
J.Biochem., 175, 2024
|
|
9CAI
 | | High-resolution C. elegans 80S ribosome structure - class 1 | | 分子名称: | 18S rRNA, 28S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Sehgal, E, Serrao, V.H.B, Arribere, J. | | 登録日 | 2024-06-17 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity.
Rna, 30, 2024
|
|
4W7E
 | | Crystal Structure of Full-Length Split GFP Mutant E124H/K126H With Copper Mediated Crystal Contacts, P 41 21 2 Space Group | | 分子名称: | COPPER (II) ION, IMIDAZOLE, fluorescent protein D21H/K26H | | 著者 | Leibly, D.J, Waldo, G.S, Yeates, T.O. | | 登録日 | 2014-08-21 | | 公開日 | 2015-02-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.592 Å) | | 主引用文献 | A Suite of Engineered GFP Molecules for Oligomeric Scaffolding.
Structure, 23, 2015
|
|
4KF5
 | | Crystal Structure of Split GFP complexed with engineered sfCherry with an insertion of GFP fragment | | 分子名称: | fluorescent protein GFP1-9, fluorescent protein sfCherry+GFP10-11 | | 著者 | Nguyen, H.B, Hung, L.-W, Yeates, T.O, Waldo, G.S, Terwilliger, T.C. | | 登録日 | 2013-04-26 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.599 Å) | | 主引用文献 | Split green fluorescent protein as a modular binding partner for protein crystallization.
Acta Crystallogr.,Sect.D, 69, 2013
|
|
6QEP
 | | EngBF DARPin Fusion 4b H14 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-01-08 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
|
|
6YV8
 | |
