6SVP

Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GlcNAc

Summary for 6SVP

Entry DOI	10.2210/pdb6svp/pdb
Descriptor	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	glutamine fructose-6-phosphate aminotransferase, gfat, ntn hydrolase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	157322.73
Authors	Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. (deposition date: 2019-09-18, release date: 2020-01-15, Last modification date: 2024-01-24)
Primary citation	Ruegenberg, S.,Horn, M.,Pichlo, C.,Allmeroth, K.,Baumann, U.,Denzel, M.S. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun, 11:687-687, 2020 Cited by PubMed: 32019926 DOI: 10.1038/s41467-020-14524-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.531 Å)

Structure validation