PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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5UQ2	Crystal structure of human Cdk2-Spy1 complex 分子名称: Cyclin-dependent kinase 2, Speedy protein A 著者 McGrath, D.A, Tripathi, S.M, Rubin, S.M. 登録日 2017-02-06 公開日 2017-07-05 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
6CQ5	TBK1 in Complex with Sulfone Analog of Amlexanox 分子名称: 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2018-03-14 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.354 Å) 主引用文献 Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
5ULA	Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402 分子名称: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4 著者 Plotnikov, A.N, Joshua, j, Zhou, M.-M. 登録日 2017-01-24 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7B9M	Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(2-sulfanylethyl)benzamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-14 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9R	Cys-45-tethered stabilizer 4 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)benzamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-14 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BA3	Cys-42-tethered stabilizer 6 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
6CQ4	TBK1 in Complex with Cyclohexyl Analog of Amlexanox 分子名称: 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2018-03-14 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity. Bioorg. Med. Chem., 26, 2018
2P2T	Crystal structure of dynein light chain LC8 bound to residues 123-138 of intermediate chain IC74 分子名称: ACETATE ION, Dynein intermediate chain peptide, Dynein light chain 1, ... 著者 Benison, G, Karplus, P.A, Barbar, E. 登録日 2007-03-07 公開日 2008-01-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and dynamics of LC8 complexes with KXTQT-motif peptides: swallow and dynein intermediate chain compete for a common site. J.Mol.Biol., 371, 2007
6BOE	TBK1 in complex with amide-coupled tetrazole analog of amlexanox 分子名称: 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide, Serine/threonine-protein kinase TBK1 著者 Beyett, T.S, Tesmer, J.J.G. 登録日 2017-11-19 公開日 2018-09-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.598 Å) 主引用文献 Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94, 2018
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs 分子名称: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-09-18 公開日 2020-11-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
5TUT	UbcH5a-Ub isopeptide conjugate 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 D1 著者 Sanchez, J.G, Wagner, J.M, Pornillos, O. 登録日 2016-11-07 公開日 2017-11-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.604 Å) 主引用文献 UbcH5a-Ub isopeptide conjugate To be Published
5X6V	Crystal structure of human heteroheptameric complex 分子名称: ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
5UFS	X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with triamcinolone acetonide and SHP coregulator fragment 分子名称: Ancestral Glucocorticoid Receptor2, SHP NR Box 1 Peptide, Triamcinolone acetonide 著者 Weikum, E.R, Ortlund, E.A. 登録日 2017-01-05 公開日 2017-04-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.118 Å) 主引用文献 Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner. Mol. Pharmacol., 92, 2017
7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-01-19 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
3MZ3	Crystal structure of Co2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
3MZ4	Crystal structure of D101L Mn2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.845 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
7BM9	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-01-19 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
5T31	Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia 分子名称: (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta 著者 Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. 登録日 2016-08-24 公開日 2018-02-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
6ATH	Cdk2/cyclin A/p27-KID-deltaC 分子名称: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... 著者 White, S.W, Yun, M. 登録日 2017-08-29 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation. Nat Commun, 10, 2019
6AVS	Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) 分子名称: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, Lysine-specific demethylase 8, ZINC ION 著者 Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. 登録日 2017-09-04 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
2VII	PspF1-275-Mg-AMP 分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Joly, N, Rappas, M, Buck, M, Zhang, X. 登録日 2007-12-04 公開日 2008-01-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Trapping of a Transcription Complex Using a New Nucleotide Analogue: AMP Aluminium Fluoride J.Mol.Biol., 375, 2008
3MZ6	Crystal structure of D101L Fe2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, FE (II) ION, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
5ZO6	Crystal structure of C166, a backbone circularized G-CSF 分子名称: Granulocyte colony-stimulating factor 著者 Shibuya, R, Miyafusa, T, Honda, S. 登録日 2018-04-12 公開日 2019-04-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stabilization of backbone-circularized protein is attained by synergistic gains in enthalpy of folded structure and entropy of unfolded structure. Febs J., 2019
5V8F	Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 分子名称: Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... 著者 Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. 登録日 2017-03-21 公開日 2017-05-10 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
3MZ7	Crystal structure of D101L Co2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, GLYCEROL, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010

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