5FFO
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![BU of 5ffo by Molmil](/molmil-images/mine/5ffo) | Integrin alpha V beta 6 in complex with pro-TGF-beta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Dong, X, Zhao, B, Springer, T.A. | 登録日 | 2015-12-18 | 公開日 | 2017-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Force interacts with macromolecular structure in activation of TGF-beta. Nature, 542, 2017
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7OP7
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![BU of 7op7 by Molmil](/molmil-images/mine/7op7) | Bacteroides thetaiotaomicron mannosidase GH2 with beta-manno-configured N-alkyl cyclophellitol aziridine | 分子名称: | (1R,2S,3R,4S,5R,6R)-5-(8-azidooctylamino)-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, BROMIDE ION, ... | 著者 | McGregor, N.G.S, Beenakker, T.J.M, Kuo, C, Wong, C, Offen, W.A, Armstrong, Z, Codee, J.D.C, Aerts, J.M.F.G, Florea, B.I, Overkleeft, H.S, Davies, G.J. | 登録日 | 2021-05-29 | 公開日 | 2022-02-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Synthesis of broad-specificity activity-based probes for exo -beta-mannosidases. Org.Biomol.Chem., 20, 2022
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7OON
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![BU of 7oon by Molmil](/molmil-images/mine/7oon) | The X-ray structure of heme-bound murine HEBP1 | 分子名称: | Heme-binding protein 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | McEwen, A.G, Poussin-Courmontagne, P, Birck, C, Goodfellow, B.J. | 登録日 | 2021-05-28 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The SOUL family of heme-binding proteins: Structure and function 15 years later Coord. Chem. Rev, 448, 2021
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8QQK
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![BU of 8qqk by Molmil](/molmil-images/mine/8qqk) | Cryo-EM structure of E. coli cytochrome bo3 quinol oxidase assembled in peptidiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, ... | 著者 | Gao, Y, Zhang, Y, Hakke, S, Peters, P.J, Ravelli, R.B.G. | 登録日 | 2023-10-05 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of cytochrome bo 3 quinol oxidase assembled in peptidiscs reveals an "open" conformation for potential ubiquinone-8 release. Biochim Biophys Acta Bioenerg, 1865, 2024
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8QDX
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6NBT
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![BU of 6nbt by Molmil](/molmil-images/mine/6nbt) | |
6QD6
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![BU of 6qd6 by Molmil](/molmil-images/mine/6qd6) | Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207 | 分子名称: | CHLORIDE ION, Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207 | 著者 | Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkonig, A, Zogg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J. | 登録日 | 2018-12-31 | 公開日 | 2019-12-18 | 最終更新日 | 2021-01-13 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM Nat.Methods, 18, 2021
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8QBH
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![BU of 8qbh by Molmil](/molmil-images/mine/8qbh) | AntI in complex with 1-Naphthol | 分子名称: | 1-NAPHTHOL, Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 15/17 | 著者 | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | 登録日 | 2023-08-24 | 公開日 | 2024-03-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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8QBI
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![BU of 8qbi by Molmil](/molmil-images/mine/8qbi) | AntI in closed state | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 15/17, ... | 著者 | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | 登録日 | 2023-08-24 | 公開日 | 2024-03-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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8RMO
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![BU of 8rmo by Molmil](/molmil-images/mine/8rmo) | Crystal structure of anti-FLAG M2 Fab fragment bound to FLAG-tag peptide epitope | 分子名称: | CHLORIDE ION, FLAG-tag, anti-FLAG M2 heavy chain, ... | 著者 | Beugelink, J.W, Janssen, B.J.C, Pronker, M.F. | 登録日 | 2024-01-08 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.163 Å) | 主引用文献 | Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2. J.Mol.Biol., 436, 2024
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8QD5
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![BU of 8qd5 by Molmil](/molmil-images/mine/8qd5) | AntI Ser245DHA (PSF) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Photorhabdus luminescens subsp. laumondii TTO1 complete genome segment 15/17, ... | 著者 | Schmalhofer, M, Vagstad, A.L, Zhou, Q, Bode, H.B, Groll, M. | 登録日 | 2023-08-28 | 公開日 | 2024-03-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments. Adv Sci, 11, 2024
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5JEO
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![BU of 5jeo by Molmil](/molmil-images/mine/5jeo) | Phosphorylated Rotavirus NSP1 in complex with IRF-3 | 分子名称: | Interferon regulatory factor 3, PHOSPHATE ION, Rotavirus NSP1 peptide | 著者 | Zhao, B, Li, P. | 登録日 | 2016-04-18 | 公開日 | 2016-06-15 | 最終更新日 | 2016-06-29 | 実験手法 | X-RAY DIFFRACTION (1.719 Å) | 主引用文献 | Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins. Proc.Natl.Acad.Sci.USA, 113, 2016
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6NIR
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4XYK
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![BU of 4xyk by Molmil](/molmil-images/mine/4xyk) | Crystal structure of human phosphofructokinase-1 in complex with ADP, Northeast Structural Genomics Consortium Target HR9275 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent 6-phosphofructokinase, platelet type, ... | 著者 | Forouhar, F, Webb, B.A, Szu, F.-E, Seetharaman, J, Barber, D.L, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2015-02-02 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature, 523, 2015
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4Y11
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![BU of 4y11 by Molmil](/molmil-images/mine/4y11) | Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4,4-trifluorobutanoic acid | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | 登録日 | 2015-02-06 | 公開日 | 2015-06-24 | 最終更新日 | 2018-04-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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5JJL
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![BU of 5jjl by Molmil](/molmil-images/mine/5jjl) | Rho transcription termination factor bound to rU8 and 5 ADP-BeF3 molecules | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Thomsen, N.D, Lawson, M.R, Witkowsky, L.B, Qu, S, Berger, J.M. | 登録日 | 2016-04-24 | 公開日 | 2016-11-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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4Y10
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![BU of 4y10 by Molmil](/molmil-images/mine/4y10) | Trypsin in complex with with BPTI mutant (2S)-2-amino-4,4-difluorobutanoic acid | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Loll, B, Ye, S, Berger, A.A, Muelow, U, Alings, C, Wahl, M.C, Koksch, B. | 登録日 | 2015-02-06 | 公開日 | 2015-06-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Fluorine teams up with water to restore inhibitor activity to mutant BPTI. Chem Sci, 6, 2015
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6UF0
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![BU of 6uf0 by Molmil](/molmil-images/mine/6uf0) | Crystal structure of N-(4-((4-methoxy-N-(2,2,2-trifluoroethyl)phenyl)sulfonamido)isoquinolin-1-yl)-N-((4-methoxyphenyl)sulfonyl)glycine bound to human Keap1 Kelch domain | 分子名称: | DIMETHYL SULFOXIDE, FORMIC ACID, Kelch-like ECH-associated protein 1, ... | 著者 | Lazzara, P.R, David, B.P, Ankireddy, A, Richardson, B.G, Dye, K, Ratia, K.M, Reddy, S.P, Moore, T.W. | 登録日 | 2019-09-23 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability. J.Med.Chem., 63, 2020
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8CC7
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![BU of 8cc7 by Molmil](/molmil-images/mine/8cc7) | Mouse serotonin 5-HT3A receptor in complex with PZ-1939 | 分子名称: | 1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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8CC6
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![BU of 8cc6 by Molmil](/molmil-images/mine/8cc6) | Mouse serotonin 5-HT3A receptor in complex with PZ-1922 | 分子名称: | 1-[(3-chlorophenyl)methyl]-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lopez-Sanchez, U, Nury, H. | 登録日 | 2023-01-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
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8TYP
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![BU of 8typ by Molmil](/molmil-images/mine/8typ) | Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide | 分子名称: | 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Geisbrecht, B.V. | 登録日 | 2023-08-25 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol., 212, 2024
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7LU9
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![BU of 7lu9 by Molmil](/molmil-images/mine/7lu9) | Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Manne, K, Edwards, R.J, Acharya, P. | 登録日 | 2021-02-21 | 公開日 | 2021-03-24 | 最終更新日 | 2021-06-09 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021
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8R3C
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8QQS
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4Y4M
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![BU of 4y4m by Molmil](/molmil-images/mine/4y4m) | Thiazole synthase Thi4 from Methanocaldococcus jannaschii | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Putative ribose 1,5-bisphosphate isomerase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3R)-2,3,5-tris(oxidanyl)-4-oxidanylidene-pentyl] hydrogen phosphate | 著者 | Zhang, X, Ealick, S.E. | 登録日 | 2015-02-10 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases. Biochemistry, 55, 2016
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