PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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5A0L	N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes 分子名称: ACETATE ION, FIBRONECTIN-BINDING PROTEIN, ZINC ION 著者 Walden, M, Edwards, J.M, Dziewulska, A.M, Kan, S.-Y, Schwarz-Linek, U, Banfield, M.J. 登録日 2015-04-21 公開日 2015-06-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 An internal thioester in a pathogen surface protein mediates covalent host binding. Elife, 4, 2015
5BVB	Engineered Digoxigenin binder DIG5.1a 分子名称: DIG5.1a, DIGOXIGENIN 著者 Doyle, L.A, Stoddard, B.L. 登録日 2015-06-04 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge. J.Chem.Inf.Model., 56, 2016
5BOT	X-RAY Co-structure of MMP-13 with ethyl 5-carbamoyl-1H-indole-2-carboxylate 分子名称: CALCIUM ION, Collagenase 3, ZINC ION, ... 著者 Farrow, N.A, Padyana, A.K. 登録日 2015-05-27 公開日 2015-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54, 2011
5APJ	Ligand complex of RORg LBD 分子名称: 2-CHLORO-6-FLUORO-N-[4-[3-(TRIFLUOROMETHYL)PHENYL]SULFONYL-3,5-DIHYDRO-2H-1,4-BENZOXAZEPIN-7-YL]BENZAMIDE, NUCLEAR RECEPTOR COACTIVATOR 2, NUCLEAR RECEPTOR ROR-GAMMA, ... 著者 Xue, Y, Aagaard, A, Narjes, F. 登録日 2015-09-16 公開日 2015-11-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR gamma. ChemMedChem, 11, 2016
5E0S	crystal structure of the active form of the proteolytic complex clpP1 and clpP2 分子名称: ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 著者 LI, M, Wlodawer, A, Maurizi, M. 登録日 2015-09-29 公開日 2016-02-17 最終更新日 2016-04-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
5DMU	Structure of the NHEJ polymerase from Methanocella paludicola 分子名称: 1,2-ETHANEDIOL, GLYCEROL, NHEJ Polymerase, ... 著者 Brissett, N.C, Bartlett, E.J, Doherty, A.J. 登録日 2015-09-09 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Res., 44, 2016
5BS9	Crystal structure of N109A mutant of human macrophage migration inhibitory factor 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... 著者 Pantouris, G, Lolis, E. 登録日 2015-06-01 公開日 2015-09-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5BOY	X-RAY Co-structure of MMP-13 with ethyl 5-(1-methyl-1H-imidazol-5-yl)-1H-indole-2-Carboxylate 分子名称: CALCIUM ION, Collagenase 3, ZINC ION, ... 著者 Farrow, N.A. 登録日 2015-05-27 公開日 2015-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54, 2011
5BTS	Structural and biophysical characterization of a covalent insulin dimer formed during storage of neutral formulation of human insulin 分子名称: Insulin A chain, Insulin B chain 著者 Norrman, M, Hjorth, C.F. 登録日 2015-06-03 公開日 2016-03-09 最終更新日 2019-02-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. J.Pharm.Sci., 105, 2016
5DW0	TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine 分子名称: SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE 著者 Buller, A.R, Arnold, F.H. 登録日 2015-09-22 公開日 2015-11-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proc.Natl.Acad.Sci.USA, 112, 2015
5DZR	Structure of RNA Helicase FRH a Critical Component of the Neurospora Crassa Circadian Clock 分子名称: FRQ-interacting RNA helicase 著者 Conrad, K.S, Crane, B.C. 登録日 2015-09-26 公開日 2016-07-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.161 Å) 主引用文献 Structure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock. Embo J., 35, 2016
5E5G	3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with D-tryptophan bound in the tryptophan and phenylalanine binding sites 分子名称: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, D-TRYPTOPHAN, MANGANESE (II) ION, ... 著者 Reichau, S, Jiao, W, Parker, E.J. 登録日 2015-10-08 公開日 2016-06-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids. Plos One, 11, 2016
5E8C	pseudorabies virus nuclear egress complex, pUL31, pUL34 分子名称: CHLORIDE ION, UL31, UL34 protein, ... 著者 Zeev-Ben-Mordehai, T, Cheleski, J, Whittle, C, El Omari, K, Harlos, K, Hagen, C, Klupp, B, Mettenleiter, T.C, Gruenewald, K. 登録日 2015-10-14 公開日 2015-12-23 最終更新日 2016-01-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling. Cell Rep, 13, 2015
5EBT	Tankyrase 1 with Phthalazinone 2 分子名称: (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, Tankyrase-1, ... 著者 Kazmirski, S.L, Johannes, J. 登録日 2015-10-19 公開日 2016-03-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
5DMP	Structure of the Archaeal NHEJ Phosphoesterase from Methanocella paludicola. 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Uncharacterized protein, ... 著者 Brissett, N.C, Bartlett, E.J, Doherty, A.J. 登録日 2015-09-09 公開日 2015-10-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.793 Å) 主引用文献 Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Res., 44, 2016
4QKV	Crystal structure of the mouse cavin1 HR1 domain 分子名称: Polymerase I and transcript release factor 著者 Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. 登録日 2014-06-10 公開日 2015-03-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural insights into the organization of the cavin membrane coat complex Dev.Cell, 31, 2014
4PY1	Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine 分子名称: 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine, Non-receptor tyrosine-protein kinase TYK2 著者 Han, S, Knafels, J.D. 登録日 2014-03-25 公開日 2014-09-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold. Bioorg.Med.Chem.Lett., 24, 2014
4PZ1	Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes 分子名称: CALCIUM ION, CHLORIDE ION, sHIP 著者 Wisniewska, M, Happonen, L, Frick, I.-M, Bjorck, L, Streicher, W, Malmstrom, J, Wikstrom, M. 登録日 2014-03-28 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes. J.Biol.Chem., 289, 2014
8IRK	Carbon Sulfoxide lyase 分子名称: PYRIDOXAL-5'-PHOSPHATE, PYRUVIC ACID, Probable hercynylcysteine sulfoxide lyase 著者 Gong, W.M, Wei, L.L, Liu, L. 登録日 2023-03-18 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure of Mycobacterial ergothioneine-biosynthesis C-S lyase EgtE To Be Published
4Q4W	High-resolution crystal structure of Coxsackievirus A24v 分子名称: CALCIUM ION, CHLORIDE ION, Coxsackievirus capsid protein VP1, ... 著者 Zocher, G, Stehle, T. 登録日 2014-04-15 公開日 2014-11-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A sialic Acid binding site in a human picornavirus. Plos Pathog., 10, 2014
4QBL	VRR_NUC domain protein 分子名称: MAGNESIUM ION, VRR-NUC 著者 Smerdon, S.J, Pennell, S, Li, J. 登録日 2014-05-08 公開日 2014-09-10 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep, 8, 2014
4QEU	Crystal structure of BRD2(BD2) mutant in free form 分子名称: ACETATE ION, Bromodomain-containing protein 2, GLYCEROL 著者 Tallant, C, Baud, M, Lin-Shiao, E, Chirgadze, D.Y, Ciulli, A. 登録日 2014-05-19 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science, 346, 2014
4PX5	Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate 分子名称: D-SORBITOL-6-PHOSPHATE, GLYCEROL, Glucokinase regulatory protein, ... 著者 Jordan, S.R, Chmait, S. 登録日 2014-03-21 公開日 2015-05-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding To be Published
4PZ5	Crystal structure of the second and third fibronectin F1 modules in complex with a fragment of BBK32 from Borrelia burgdorferi 分子名称: Fibronectin, Fibronectin-binding protein BBK32 著者 Harris, G, Potts, J.R. 登録日 2014-03-28 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Borrelia burgdorferi Protein BBK32 Binds to Soluble Fibronectin via the N-terminal 70-kDa Region, Causing Fibronectin to Undergo Conformational Extension. J.Biol.Chem., 289, 2014
4Q4V	Crystal structure of Coxsackievirus A24v 分子名称: Coxsackievirus capsid protein VP1, Coxsackievirus capsid protein VP2, Coxsackievirus capsid protein VP3, ... 著者 Zocher, G, Stehle, T. 登録日 2014-04-15 公開日 2014-11-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A sialic Acid binding site in a human picornavirus. Plos Pathog., 10, 2014

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