4PY1

Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine

Summary for 4PY1

Entry DOI	10.2210/pdb4py1/pdb
Descriptor	Non-receptor tyrosine-protein kinase TYK2, 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36918.98
Authors	Han, S.,Knafels, J.D. (deposition date: 2014-03-25, release date: 2014-09-03, Last modification date: 2024-03-06)
Primary citation	Galatsis, P.,Henderson, J.L.,Kormos, B.L.,Han, S.,Kurumbail, R.G.,Wager, T.T.,Verhoest, P.R.,Noell, G.S.,Chen, Y.,Needle, E.,Berger, Z.,Steyn, S.J.,Houle, C.,Hirst, W.D. Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold. Bioorg.Med.Chem.Lett., 24:4132-4140, 2014 Cited by PubMed: 25113930 DOI: 10.1016/j.bmcl.2014.07.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation