PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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8EML	Crystal Structure of Gsx2 Homeodomain in Complex with DNA 分子名称: DNA (5'-D(P*GP*AP*GP*CP*TP*AP*AP*TP*TP*AP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*TP*TP*AP*AP*TP*TP*AP*GP*CP*TP*C)-3'), GS homeobox 2, ... 著者 Webb, J.A, Kovall, R.A. 登録日 2022-09-28 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal Structure of Gsx2 Homeodomain in Complex with DNA To Be Published
5IF1	Crystal structure apo CDK2/cyclin A 分子名称: Cyclin-A2, Cyclin-dependent kinase 2 著者 Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. 登録日 2016-02-25 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
8ERN	Cyclin-free CDK2 in complex with Cpd21 分子名称: Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide 著者 Murray, J.M, Oh, A. 登録日 2022-10-12 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Cyclin-free CDK2 in complex with Cpd21 To Be Published
5IFR	Structure of the stable UBE2D3-UbDha conjugate 分子名称: GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3 著者 Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D. 登録日 2016-02-26 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nat.Chem.Biol., 12, 2016
8ERD	Cyclin-free CDK2 in complex with Cpd17 分子名称: (2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2S)-2-methylpyrrolidin-1-yl]methanone, Cyclin-dependent kinase 2 著者 Murray, J.M, Oh, A. 登録日 2022-10-11 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Cyclin-free CDK2 in complex with Cpd17 To Be Published
6YLU	14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, BLNKpT152, MAGNESIUM ION 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-04-07 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure J.Struct.Biol., 2020
5ILS	Autoinhibited ETV1 分子名称: ETS translocation variant 1 著者 Whitby, F.G, Currie, S.L. 登録日 2016-03-04 公開日 2017-02-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
6YL6	Cdk2(F80C) 分子名称: Cyclin-dependent kinase 2 著者 Craven, G, Morgan, R.M.L, Mann, D.J. 登録日 2020-04-06 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
6Y1D	Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (DBD) phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Estrogen related receptor gamma phosphopeptide, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2020-02-12 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
6Y3M	14-3-3 Sigma in complex with phosphorylated ATPase peptide 分子名称: 14-3-3 protein sigma, ATPase peptide, CALCIUM ION, ... 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-02-18 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
5IEV	Crystal structure of BAY 1000394 (Roniciclib) bound to CDK2 分子名称: Cyclin-dependent kinase 2, Roniciclib 著者 Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. 登録日 2016-02-25 公開日 2016-04-27 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
6Y8E	14-3-3 Sigma in complex with phosphorylated MLF1 peptide 分子名称: 14-3-3 protein sigma, ARG-SER-PHE-SEP-GLU-PRO-PHE-GLY, CALCIUM ION, ... 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-03-04 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
8F7L	Human NAMPT in complex with substrate NAM and small molecule activator ZN-29-S 分子名称: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[(2P)-2-(3-fluoro-4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]piperidine-3-carboxamide, CHLORIDE ION, NICOTINAMIDE, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-11-18 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Human NAMPT in complex with substrate NAM and small molecule activator ZN-29-S To Be Published
6YOY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-025 分子名称: 14-3-3 protein sigma, 5-methyl-2-nitrophenol, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YP2	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-011 分子名称: 1-(4-methylphenyl)imidazole, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
5IBK	Skp1-F-box in complex with a ubiquitin variant 分子名称: F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 著者 Orlicky, S, Sicheri, F. 登録日 2016-02-22 公開日 2016-03-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113, 2016
6Y35	CCAAT-binding complex from Aspergillus fumigatus with cycA DNA 分子名称: CCAAT-binding factor complex subunit HapC, CCAAT-binding factor complex subunit HapE, CCAAT-binding transcription factor subunit HAPB, ... 著者 Groll, M, Huber, E.M. 登録日 2020-02-17 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus . Life Sci Alliance, 3, 2020
6Y58	Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (LBD) phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Related Receptor gamma phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Sijbesma, E, Leijten-van de Gevel, I.A, Ottmann, C. 登録日 2020-02-25 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.904 Å) 主引用文献 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
6YP3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-028 分子名称: 1-(4-methylphenyl)-1,2,4-triazole, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YP8	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-033 分子名称: 14-3-3 protein sigma, 3-imidazol-1-ylbenzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
7YLV	yeast TRiC-plp2-substrate complex at S2 ATP binding state 分子名称: Phosducin-like protein 2, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... 著者 Han, W.Y. 登録日 2022-07-27 公開日 2023-03-29 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.91 Å) 主引用文献 Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
7YLU	yeast TRiC-plp2-substrate complex at S1 TRiC-NPP state 分子名称: Phosducin-like protein 2, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... 著者 Han, W.Y. 登録日 2022-07-27 公開日 2023-03-29 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (4.55 Å) 主引用文献 Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT. Sci Adv, 9, 2023
6Y39	HapE-P88L mutant CCAAT-binding complex from Aspergillus nidulans with cycA DNA 分子名称: CBFD_NFYB_HMF domain-containing protein, CHLORIDE ION, DNA (25 mer), ... 著者 Groll, M, Huber, E.M. 登録日 2020-02-17 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus . Life Sci Alliance, 3, 2020
6Y3S	14-3-3 Sigma in complex with phosphorylated (pS210) Gab2 peptide 分子名称: 14-3-3 protein sigma, Gab2, MAGNESIUM ION 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-02-18 公開日 2020-10-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
4HHY	Crystal structure of PARP catalytic domain in complex with novel inhibitors 分子名称: (9aR)-1-[(1-{2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoyl}piperidin-4-yl)carbonyl]-1,2,3,8,9,9a-hexahydro-7H-benzo[de][1,7]naphthyridin-7-one, DI(HYDROXYETHYL)ETHER, Poly [ADP-ribose] polymerase 1, ... 著者 Liu, Q.F, Chen, T.T, Xu, Y.C. 登録日 2012-10-10 公開日 2013-03-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3637 Å) 主引用文献 Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors. J.Med.Chem., 56, 2013

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