PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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4S05	Crystal structure of Klebsiella pneumoniae PmrA in complex with PmrA box DNA 分子名称: BERYLLIUM TRIFLUORIDE ION, DNA (26-MER), DNA-binding transcriptional regulator BasR, ... 著者 Hsiao, C.D, Weng, T.H, Li, Y.C. 登録日 2014-12-30 公開日 2015-11-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA. Nat Commun, 6, 2015
2DAO	Solution structure of ETS domain Transcriptional factor ETV6 protein 分子名称: Transcription factor ETV6 著者 Niraula, T.N, Sasagawa, A, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-14 公開日 2006-12-12 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of ETS domain Transcriptional factor ETV6 protein To be Published
3DKL	Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, BENZAMIDE, BERYLLIUM TRIFLUORIDE ION, ... 著者 Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. 登録日 2008-06-25 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
3DHD	Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate 分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, MAGNESIUM ION, Nicotinamide phosphoribosyltransferase, ... 著者 Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. 登録日 2008-06-17 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
2DMU	Solution structure of the homeobox domain of Homeobox protein goosecoid 分子名称: Homeobox protein goosecoid 著者 Ohnishi, S, Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-24 公開日 2006-10-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the homeobox domain of Homeobox protein goosecoid To be Published
2DOE	Solution structure of the third FF domain of human transcription factor CA150 分子名称: Transcription elongation regulator 1 著者 Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-28 公開日 2006-10-28 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the third FF domain of human transcription factor CA150 To be Published
4QA5	Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... 著者 Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2014-05-02 公開日 2014-08-06 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QAL	Crystal structure of C117A mutant of human acidic fibroblast growth factor 分子名称: CITRATE ANION, Fibroblast growth factor 1 著者 Blaber, M, Xia, X. 登録日 2014-05-05 公開日 2015-03-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mutation choice to eliminate buried free cysteines in protein therapeutics. J.Pharm.Sci., 104, 2015
2CRA	Solution structure of the homeobox domain of human homeo box B13 分子名称: Homeobox protein Hox-B13 著者 Seimiya, K, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-20 公開日 2005-11-20 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the homeobox domain of human homeo box B13 To be published
4TTH	Crystal structure of a CDK6/Vcyclin complex with inhibitor bound 分子名称: 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, Cyclin homolog, Cyclin-dependent kinase 6 著者 Piper, D.E, Walker, N, Wang, Z. 登録日 2014-06-20 公開日 2014-08-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J.Med.Chem., 57, 2014
2CXK	Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1) 分子名称: SULFATE ION, calmodulin binding transcription activator 1 著者 Pioszak, A.A, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-06-30 公開日 2005-12-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of the TIG domain of human calmodulin-binding transcription activator 1 (CAMTA1) To be Published
4QA0	Crystal structure of C153F HDAC8 in complex with SAHA 分子名称: GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... 著者 Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2014-05-02 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.242 Å) 主引用文献 Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QO3	Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor 分子名称: CITRATE ANION, Fibroblast growth factor 1, IMIDAZOLE 著者 Blaber, M, Xia, X. 登録日 2014-06-19 公開日 2015-05-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.047 Å) 主引用文献 Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins To be Published
4QA3	Crystal structure of T311M HDAC8 in complex with Trichostatin A (TSA) 分子名称: GLYCEROL, Histone deacetylase 8, POTASSIUM ION, ... 著者 Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2014-05-02 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.876 Å) 主引用文献 Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
2AFG	2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR 分子名称: ACIDIC FIBROBLAST GROWTH FACTOR, SULFATE ION 著者 Blaber, M, Disalvo, J, Thomas, K.A. 登録日 1995-07-21 公開日 1995-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 X-ray crystal structure of human acidic fibroblast growth factor. Biochemistry, 35, 1996
4S3O	PCGF5-RING1B-UbcH5c complex 分子名称: E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... 著者 Taherbhoy, A.M, Cochran, A.G. 登録日 2015-03-23 公開日 2015-07-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun, 6, 2015
2DMT	Solution structure of the homeobox domain of Homeobox protein BarH-like 1 分子名称: Homeobox protein BarH-like 1 著者 Ohnishi, S, Yoneyama, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-24 公開日 2006-10-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the homeobox domain of Homeobox protein BarH-like 1 To be Published
2DOF	Solution structure of the fourth FF domain of human transcription factor CA150 分子名称: Transcription elongation regulator 1 著者 Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-28 公開日 2006-10-28 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the fourth FF domain of human transcription factor CA150 To be Published
2DJN	The solution structure of the homeobox domain of human Homeobox protein DLX-5 分子名称: Homeobox protein DLX-5 著者 Sasagawa, A, Ohnishi, S, Tochio, N, Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-05 公開日 2006-10-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The solution structure of the homeobox domain of human Homeobox protein DLX-5 To be Published
2DO3	Solution structure of the third KOW motif of transcription elongation factor SPT5 分子名称: Transcription elongation factor SPT5 著者 Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-27 公開日 2006-10-27 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the third KOW motif of transcription elongation factor SPT5 To be Published
3F0R	Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form 分子名称: Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2008-10-25 公開日 2008-12-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
4J1Z	Tankyrase 2 in complex with 4-chloro-1,2-dihydrophatalzin-one 分子名称: 4-chlorophthalazin-1(2H)-one, SULFATE ION, Tankyrase-2, ... 著者 Jansson, A.E. 登録日 2013-02-03 公開日 2013-07-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based ligand design of novel potent inhibitors of tankyrases. J.Med.Chem., 56, 2013
2B53	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325 分子名称: 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE, Cell division protein kinase 2 著者 Muckelbauer, J. 登録日 2005-09-27 公開日 2005-10-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Quinazolines as Cyclin Dependent Kinase Inhibitors Bioorg.Med.Chem.Lett., 11, 2001
2B55	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312 分子名称: 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE, Cell division protein kinase 2 著者 Muckelbauer, J. 登録日 2005-09-27 公開日 2005-10-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 J.Med.Chem., 45, 2002
2B54	Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305 分子名称: 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE, Cell division protein kinase 2 著者 Chang, C.-C. 登録日 2005-09-27 公開日 2005-10-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases J.Med.Chem., 47, 2004

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