5L2S
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![BU of 5l2s by Molmil](/molmil-images/mine/5l2s) | The X-ray co-crystal structure of human CDK6 and Abemaciclib. | 分子名称: | Cyclin-dependent kinase 6, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | 著者 | Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A. | 登録日 | 2016-08-02 | 公開日 | 2016-08-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15, 2016
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2DA1
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![BU of 2da1 by Molmil](/molmil-images/mine/2da1) | Solution structure of the first homeobox domain of AT-binding transcription factor 1 (ATBF1) | 分子名称: | Alpha-fetoprotein enhancer binding protein | 著者 | Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-12-13 | 公開日 | 2006-06-13 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the first homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
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2DA6
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![BU of 2da6 by Molmil](/molmil-images/mine/2da6) | Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) | 分子名称: | Hepatocyte nuclear factor 1-beta | 著者 | Ohnishi, S, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-12-13 | 公開日 | 2006-12-26 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) To be Published
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8AV8
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![BU of 8av8 by Molmil](/molmil-images/mine/8av8) | Small molecular stabilizer for ERalpha and 14-3-3 (1075300) | 分子名称: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(1-phenoxycyclopentyl)carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | 登録日 | 2022-08-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
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8ANC
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2B52
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![BU of 2b52 by Molmil](/molmil-images/mine/2b52) | Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562 | 分子名称: | 1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA, Cell division protein kinase 2 | 著者 | Muckelbauer, J. | 登録日 | 2005-09-27 | 公開日 | 2005-10-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. Part 4: Heterocycles at C3 Bioorg.Med.Chem.Lett., 14, 2004
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2QCS
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![BU of 2qcs by Molmil](/molmil-images/mine/2qcs) | A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state | 分子名称: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. | 登録日 | 2007-06-19 | 公開日 | 2007-11-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130, 2007
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3F07
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![BU of 3f07 by Molmil](/molmil-images/mine/3f07) | Crystal Structure Analysis of Human HDAC8 complexed with APHA in a new monoclinic crystal form | 分子名称: | (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide, Histone deacetylase 8, POTASSIUM ION, ... | 著者 | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | 登録日 | 2008-10-24 | 公開日 | 2008-12-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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1Z4H
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![BU of 1z4h by Molmil](/molmil-images/mine/1z4h) | The response regulator TorI belongs to a new family of atypical excisionase | 分子名称: | Tor inhibition protein | 著者 | Elantak, L, Ansaldi, M, Guerlesquin, F, Mejean, V, Morelli, X. | 登録日 | 2005-03-16 | 公開日 | 2005-08-09 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and genetic analyses reveal a key role in prophage excision for the TorI response regulator inhibitor J.Biol.Chem., 280, 2005
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4RAF
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![BU of 4raf by Molmil](/molmil-images/mine/4raf) | Crystal structure of PP2Ca-D38A | 分子名称: | MANGANESE (II) ION, Protein phosphatase 1A | 著者 | Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. | 登録日 | 2014-09-10 | 公開日 | 2015-08-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | The catalytic role of the M2 metal ion in PP2C alpha Sci Rep, 5, 2015
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2D9Q
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![BU of 2d9q by Molmil](/molmil-images/mine/2d9q) | Crystal Structure of the Human GCSF-Receptor Signaling Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CSF3, Granulocyte colony-stimulating factor receptor | 著者 | Tamada, T, Kuroki, R. | 登録日 | 2005-12-12 | 公開日 | 2006-02-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Proc.Natl.Acad.Sci.Usa, 103, 2006
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4PTE
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![BU of 4pte by Molmil](/molmil-images/mine/4pte) | Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b | 分子名称: | Glycogen synthase kinase-3 beta, N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | 登録日 | 2014-03-10 | 公開日 | 2015-04-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.033 Å) | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
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4PSF
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![BU of 4psf by Molmil](/molmil-images/mine/4psf) | PIH1D1 N-terminal domain | 分子名称: | PIH1 domain-containing protein 1 | 著者 | Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. | 登録日 | 2014-03-07 | 公開日 | 2014-04-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.578 Å) | 主引用文献 | Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex. Cell Rep, 7, 2014
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2DA3
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![BU of 2da3 by Molmil](/molmil-images/mine/2da3) | Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) | 分子名称: | Alpha-fetoprotein enhancer binding protein | 著者 | Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2005-12-13 | 公開日 | 2006-06-13 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
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4PTG
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![BU of 4ptg by Molmil](/molmil-images/mine/4ptg) | Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b | 分子名称: | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide, Glycogen synthase kinase-3 beta | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | 登録日 | 2014-03-10 | 公開日 | 2015-04-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.361 Å) | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
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2W17
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![BU of 2w17 by Molmil](/molmil-images/mine/2w17) | CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b | 分子名称: | ACETATE ION, CELL DIVISION PROTEIN KINASE 2, N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine | 著者 | Jones, C.D, Andrews, D.M, Barker, A.J, Blades, K, Daunt, P, East, S, Geh, C, Graham, M.A, Johnson, K.M, Loddick, S.A, McFarland, H.M, McGregor, A, Moss, L, Rudge, D.A, Simpson, P.B, Swain, M.L, Tam, K.Y, Tucker, J.A, Walker, M, Brassington, C, Haye, H, McCall, E. | 登録日 | 2008-10-15 | 公開日 | 2008-11-04 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The Discovery of Azd5597, a Potent Imidazole Pyrimidine Amide Cdk Inhibitor Suitable for Intravenous Dosing. Bioorg.Med.Chem.Lett., 18, 2008
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4RJ3
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![BU of 4rj3 by Molmil](/molmil-images/mine/4rj3) | CDK2 with EGFR inhibitor compound 8 | 分子名称: | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, ACETATE ION, Cyclin-dependent kinase 2 | 著者 | Eigenbrot, C, Yin, J. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4Q9P
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4QA1
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![BU of 4qa1 by Molmil](/molmil-images/mine/4qa1) | Crystal structure of A188T HDAC8 in complex with M344 | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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4QFQ
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4PVZ
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![BU of 4pvz by Molmil](/molmil-images/mine/4pvz) | Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh2 | 分子名称: | Importin subunit alpha, Inner nuclear membrane protein HEH2 | 著者 | Lokareddy, R.K, Hapsari, A.R, van Rheenen, M, Bhardwaj, A, Veenhoff, L.M, Cingolani, C. | 登録日 | 2014-03-18 | 公開日 | 2015-08-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure, 23, 2015
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4Q91
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4QA4
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![BU of 4qa4 by Molmil](/molmil-images/mine/4qa4) | Crystal structure of H334R HDAC8 in complex with M344 | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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3RDH
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![BU of 3rdh by Molmil](/molmil-images/mine/3rdh) | X-ray induced covalent inhibition of 14-3-3 | 分子名称: | 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION | 著者 | Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. | 登録日 | 2011-04-01 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
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3L30
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![BU of 3l30 by Molmil](/molmil-images/mine/3l30) | Crystal structure of porcine pancreatic phospholipase A2 complexed with dihydroxyberberine | 分子名称: | 4,14-dihydro-8H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline-9,10-diol, CALCIUM ION, CHLORIDE ION, ... | 著者 | Naveen, C, Prasanth, G.K, Abhilash, J, Pradeep, M, Ponnuraj, K, Sadasivan, C, Haridas, M. | 登録日 | 2009-12-16 | 公開日 | 2010-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of porcine pancreatic phospholipase A2 complexed with dihydroxyberberine To be Published
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