2FOU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fou by Molmil](/molmil-images/mine/2fou) | |
2FOS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fos by Molmil](/molmil-images/mine/2fos) | |
2FOQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2foq by Molmil](/molmil-images/mine/2foq) | |
2FNN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fnn by Molmil](/molmil-images/mine/2fnn) | Activation of human carbonic anhydrase II by exogenous proton donors | 分子名称: | 4-METHYLIMIDAZOLE, Carbonic Anhydrase 2, ZINC ION | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
|
|
2FNM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fnm by Molmil](/molmil-images/mine/2fnm) | Activation of human carbonic anhdyrase II by exogenous proton donors | 分子名称: | ZINC ION, carbonic anhydrase 2 | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
|
|
2FNK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fnk by Molmil](/molmil-images/mine/2fnk) | Activation of Human Carbonic Anhydrase II by exogenous proton donors | 分子名称: | Carbonic anhydrase 2, ZINC ION | 著者 | Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N. | 登録日 | 2006-01-11 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys.J., 92, 2007
|
|
2FMZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fmz by Molmil](/molmil-images/mine/2fmz) | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine, structure with D-Phenylalanine. | 分子名称: | Carbonic anhydrase 2, D-PHENYLALANINE, MERCURY (II) ION, ... | 著者 | Temperini, C, Scozzafava, A, Vullo, D, Supuran, C.T. | 登録日 | 2006-01-10 | 公開日 | 2006-05-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design. J.Med.Chem., 49, 2006
|
|
2FMG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fmg by Molmil](/molmil-images/mine/2fmg) | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D- phenylalanine and crystallographic analysis of their adducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design, structure with L-phenylalanine | 分子名称: | Carbonic anhydrase 2, MERCURY (II) ION, PHENYLALANINE, ... | 著者 | Temperini, C, Scozzafava, A, Vullo, D, Supuran, C.T. | 登録日 | 2006-01-09 | 公開日 | 2006-05-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Carbonic Anhydrase Activators. Activation of Isoforms I, II, IV, VA, VII, and XIV with l- and d-Phenylalanine and Crystallographic Analysis of Their Adducts with Isozyme II: Stereospecific Recognition within the Active Site of an Enzyme and Its Consequences for the Drug Design. J.Med.Chem., 49, 2006
|
|
2F14
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f14 by Molmil](/molmil-images/mine/2f14) | Tne Crystal Structure of the Human Carbonic Anhydrase II in Complex with a Fluorescent Inhibitor | 分子名称: | 4-(HYDROXYMERCURY)BENZOIC ACID, 5-{[({2-[4-(AMINOSULFONYL)PHENYL]ETHYL}AMINO)CARBONOTHIOYL]AMINO}-2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)BENZOIC ACID, Carbonic anhydrase 2, ... | 著者 | Alterio, V, Pedone, C, De Simone, G. | 登録日 | 2005-11-14 | 公開日 | 2006-10-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX. J.Am.Chem.Soc., 128, 2006
|
|
2EZ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ez7 by Molmil](/molmil-images/mine/2ez7) | Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: engineering proton transfer processes within the active site of an enzyme | 分子名称: | Carbonic anhydrase 2, D-HISTIDINE, MERCURY (II) ION, ... | 著者 | Temperini, C, Scozzafava, A, Vullo, D, Supuran, C.T. | 登録日 | 2005-11-10 | 公開日 | 2006-07-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, VA, VII, and XIV with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton-Transfer Processes within the Active Site of an Enzyme. Chemistry, 12, 2006
|
|
2EU3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2eu3 by Molmil](/molmil-images/mine/2eu3) | Human Carbonic anhydrase II in complex with novel inhibitors | 分子名称: | 1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE, Carbonic anhydrase 2, ZINC ION | 著者 | Fisher, S.Z, Govindasamy, L, Boyle, N, Agbandje-McKenna, M, Silverman, D.N, Blackburn, G.M, McKenna, R. | 登録日 | 2005-10-28 | 公開日 | 2006-07-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes. Acta Crystallogr.,Sect.F, 62, 2006
|
|
2EU2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2eu2 by Molmil](/molmil-images/mine/2eu2) | Human Carbonic Anhydrase II in complex with novel inhibitors | 分子名称: | (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE, Carbonic anhydrase 2, ZINC ION | 著者 | Fisher, S.Z, Govindasamy, L, Boyle, N, Agbandje-McKenna, M, Silverman, D.N, Blackburn, G.M, McKenna, R. | 登録日 | 2005-10-28 | 公開日 | 2006-07-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes. Acta Crystallogr.,Sect.F, 62, 2006
|
|
2CBE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cbe by Molmil](/molmil-images/mine/2cbe) | |
2CBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cbd by Molmil](/molmil-images/mine/2cbd) | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | 分子名称: | CARBONIC ANHYDRASE II, SULFITE ION, ZINC ION | 著者 | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | 登録日 | 1992-06-01 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes. J.Mol.Biol., 227, 1992
|
|
2CBC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cbc by Molmil](/molmil-images/mine/2cbc) | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | 分子名称: | CARBONIC ANHYDRASE II, FORMIC ACID, MERCURY (II) ION, ... | 著者 | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | 登録日 | 1992-06-01 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes. J.Mol.Biol., 227, 1992
|
|
2CBB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cbb by Molmil](/molmil-images/mine/2cbb) | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | 分子名称: | CARBONIC ANHYDRASE II, ZINC ION | 著者 | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | 登録日 | 1992-06-01 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes. J.Mol.Biol., 227, 1992
|
|
2CBA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cba by Molmil](/molmil-images/mine/2cba) | STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | 分子名称: | CARBONIC ANHYDRASE II, ZINC ION | 著者 | Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A. | 登録日 | 1992-06-01 | 公開日 | 1993-10-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes. J.Mol.Biol., 227, 1992
|
|
2CAB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2cab by Molmil](/molmil-images/mine/2cab) | STRUCTURE, REFINEMENT AND FUNCTION OF CARBONIC ANHYDRASE ISOZYMES. REFINEMENT OF HUMAN CARBONIC ANHYDRASE I | 分子名称: | CARBONIC ANHYDRASE FORM B, ZINC ION | 著者 | Kannan, K.K, Ramanadham, M, Jones, T.A. | 登録日 | 1983-10-05 | 公開日 | 1984-02-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure, refinement, and function of carbonic anhydrase isozymes: refinement of human carbonic anhydrase I Ann.N.Y.Acad.Sci., 429, 1984
|
|
2CA2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ca2 by Molmil](/molmil-images/mine/2ca2) | CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H | 分子名称: | CARBONIC ANHYDRASE II, MERCURY (II) ION, THIOCYANATE ION, ... | 著者 | Eriksson, A.E, Kylsten, P.M, Jones, T.A, Liljas, A. | 登録日 | 1989-02-06 | 公開日 | 1990-01-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH. Proteins, 4, 1988
|
|
2AX2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ax2 by Molmil](/molmil-images/mine/2ax2) | Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II | 分子名称: | Carbonic anhydrase II, ZINC ION | 著者 | Budayova-Spano, M, Fisher, S.Z, Dauvergne, M.T, Silverman, D.N, Myles, D.A.A, McKenna, R.M. | 登録日 | 2005-09-02 | 公開日 | 2006-01-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallogr.,Sect.F, 62, 2006
|
|
2AW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2aw1 by Molmil](/molmil-images/mine/2aw1) | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib | 分子名称: | 4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase II, ... | 著者 | Di Fiore, A, Pedone, C, D'Ambrosio, K, Scozzafava, A, De Simone, G, Supuran, C.T. | 登録日 | 2005-08-31 | 公開日 | 2006-07-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II Bioorg.Med.Chem.Lett., 16, 2006
|
|
2ABE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2abe by Molmil](/molmil-images/mine/2abe) | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators | 分子名称: | Carbonic anhydrase II, HISTIDINE, MERCURY (II) ION, ... | 著者 | Temperini, C, Scozzafava, A, Puccetti, L, Supuran, C.T. | 登録日 | 2005-07-15 | 公開日 | 2005-10-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with l-histidine as a platform for the design of stronger activators. Bioorg.Med.Chem.Lett., 15, 2005
|
|
1ZSC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zsc by Molmil](/molmil-images/mine/1zsc) | |
1ZSB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zsb by Molmil](/molmil-images/mine/1zsb) | CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION | 著者 | Lesburg, C.A, Christianson, D.W. | 登録日 | 1996-01-09 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
|
|
1ZSA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zsa by Molmil](/molmil-images/mine/1zsa) | |