PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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7V3U	Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Cheng, J, Li, N, Huo, Y, Dang, S, Tye, B, Gao, N, Zhai, Y. 登録日 2021-08-11 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
7V3V	Cryo-EM structure of MCM double hexamer bound with DDK in State I 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... 著者 Cheng, J, Li, N, Huo, Y, Dang, S, Tye, B, Gao, N, Zhai, Y. 登録日 2021-08-11 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
6EHP	The crystal structure of the human LAMTOR complex 分子名称: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Scheffzek, K, Naschberger, A. 登録日 2017-09-14 公開日 2017-10-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
7VLT	Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim 分子名称: (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Chen, L, Ding, D. 登録日 2021-10-05 公開日 2022-05-18 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
7VLR	Structure of SUR2B in complex with Mg-ATP/ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... 著者 Chen, L, Ding, D. 登録日 2021-10-05 公開日 2022-05-18 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
7VLU	Structure of SUR2A in complex with Mg-ATP/ADP and P1075 分子名称: 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Chen, L, Ding, D. 登録日 2021-10-05 公開日 2022-05-18 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
7VLS	Structure of SUR2B in complex with MgATP/ADP and P1075 分子名称: 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Chen, L, Ding, D. 登録日 2021-10-05 公開日 2022-05-18 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
8T1J	Uncrosslinked nNOS-CaM oxygenase homodimer 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase 1, ... 著者 Lee, K, Pospiech, T.H, Southworth, D. 登録日 2023-06-02 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. J.Biol.Chem., 300, 2023
8T9U	Human PU.1 ETS-domain (165-270) in complex with d(AATAAGCGIAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2023-06-26 公開日 2023-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure, 32, 2024
8T1K	DSBU crosslinked nNOS-CaM oxygenase homodimer 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase 1, ... 著者 Lee, K, Pospiech, T.H, Southworth, D. 登録日 2023-06-02 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. J.Biol.Chem., 300, 2023
7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
4PSI	PIH1D1/phospho-Tel2 complex 分子名称: PIH1 domain-containing protein 1, Telomere length regulation protein TEL2 homolog 著者 Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. 登録日 2014-03-07 公開日 2014-04-23 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex. Cell Rep, 7, 2014
4PTC	Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b 分子名称: 2-[2-(cyclopropylcarbonylamino)pyridin-4-yl]-4-methoxy-1,3-thiazole-5-carboxamide, Glycogen synthase kinase-3 beta 著者 Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. 登録日 2014-03-10 公開日 2015-04-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.711 Å) 主引用文献 Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
7VD4	Crystal structure of BPTF-BRD with ligand TP248 bound 分子名称: 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Lu, T, Lu, H.B. 登録日 2021-09-06 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.85659146 Å) 主引用文献 Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123, 2022
6E68	NAMPT co-crystal with inhibitor compound 2 分子名称: (2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Waight, A.B, Neumann, C.S. 登録日 2018-07-24 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 NAMPT co-crystal with inhibitor compound 2 to be published
6E69	Ortho-substituted phenyl sulfonyl fluoride and fluorosulfate as potent elastase inhibitory fragments 分子名称: 2-(fluorosulfonyl)benzene-1-sulfonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wolan, D.W, Woehl, J.L, Kitamura, S. 登録日 2018-07-24 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. Proc.Natl.Acad.Sci.USA, 116, 2019
3HGD	Crystal Structure of 2-Se-Thymidine Derivatized DNA 分子名称: 5'-D(*GP*(UMS)P*GP*(US3)P*AP*CP*AP*C)-3' 著者 Sheng, J, Hassan, A.E, Zhang, W, Huang, Z. 登録日 2009-05-13 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 High fidelity of base pairing by 2-selenothymidine in DNA. J.Am.Chem.Soc., 132, 2010
3FHI	Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA 分子名称: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Kim, C. 登録日 2008-12-09 公開日 2009-04-14 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science, 307, 2005
4PTE	Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b 分子名称: Glycogen synthase kinase-3 beta, N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide 著者 Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. 登録日 2014-03-10 公開日 2015-04-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.033 Å) 主引用文献 Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg.Med.Chem.Lett., 25, 2015
4QA5	Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... 著者 Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. 登録日 2014-05-02 公開日 2014-08-06 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
4QAL	Crystal structure of C117A mutant of human acidic fibroblast growth factor 分子名称: CITRATE ANION, Fibroblast growth factor 1 著者 Blaber, M, Xia, X. 登録日 2014-05-05 公開日 2015-03-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mutation choice to eliminate buried free cysteines in protein therapeutics. J.Pharm.Sci., 104, 2015
3HSW	Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with 2-methoxycyclohexa-2-5-diene-1,4-dione 分子名称: 2-methoxycyclohexa-2,5-diene-1,4-dione, CALCIUM ION, Phospholipase A2, ... 著者 Dileep, K.V, Tintu, I, Karthe, P, Mandal, P.K, Haridas, M, Sadasivan, C. 登録日 2009-06-11 公開日 2009-06-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione Frontiers in life sci., 2012
4QIB	Oxidation-Mediated Inhibition of the Peptidyl-Prolyl Isomerase Pin1 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION 著者 Innes, B.T, Sowole, M.A, Konermann, L, Litchfield, D.W, Brandl, C.J, Shilton, B.H. 登録日 2014-05-30 公開日 2015-02-04 最終更新日 2015-03-04 実験手法 X-RAY DIFFRACTION (1.865 Å) 主引用文献 Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1. Biochim.Biophys.Acta, 1852, 2015
7W8G	Cryo-EM structure of MCM double hexamer 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Cheng, J, Li, N, Tye, B, Zhai, Y, Gao, N. 登録日 2021-12-07 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022

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