PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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3G9N	JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one 分子名称: (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime, Mitogen-activated protein kinase 10 著者 Jacobs, M.D. 登録日 2009-02-13 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
1W20	Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 291 K 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Rudino-Pinera, E, Tunnah, P, Crennell, S.J, Webster, R.G, Laver, W.G, Garman, E.F. 登録日 2004-06-24 公開日 2006-01-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 The Crystal Structure of Type a Influenza Virus Neuraminidase of the N6 Subtype Reveals the Existence of Two Separate Neu5Ac Binding Sites To be Published
1W92	The structure of carbomonoxy murine neuroglobin reveals a heme- sliding mechanism for affinity regulation 分子名称: CARBON MONOXIDE, NEUROGLOBIN, PROTOPORPHYRIN IX CONTAINING FE 著者 Vallone, B, Nienhaus, K, Matthes, A, Brunori, M, Nienhaus, G.U. 登録日 2004-10-05 公開日 2004-11-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Structure of Carbonmonoxy Neuroglobin Reveals a Heme-Sliding Mechanism for Control of Ligand Affinity Proc.Natl.Acad.Sci.USA, 101, 2004
1W2R	Solution structure of CR2 SCR 1-2 by X-ray scattering 分子名称: COMPLEMENT RECEPTOR TYPE 2 PRECURSOR, 著者 Gilbert, H.E, Hannan, J.P, Holers, V.M, Perkins, S.J. 登録日 2004-07-08 公開日 2005-09-29 最終更新日 2024-05-08 実験手法 SOLUTION SCATTERING 主引用文献 Solution Structure of the Complex between Cr2 Scr 1-2 and C3D of Human Complement: An X-Ray Scattering and Sedimentation Modelling Study. J.Mol.Biol., 346, 2005
8IYX	Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 分子名称: 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 著者 Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. 登録日 2023-04-06 公開日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
1JW8	1.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF P6 FORM OF MYOGLOBIN 分子名称: CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Phillips Jr, G.N. 登録日 2001-09-03 公開日 2001-10-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Sampling of the native conformational ensemble of myoglobin via structures in different crystalline environments. Proteins, 70, 2008
2DA3	Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) 分子名称: Alpha-fetoprotein enhancer binding protein 著者 Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-13 公開日 2006-06-13 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
3VN9	Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state 分子名称: 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine, Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION 著者 Kinoshita, T, Matsuzaka, H, Nakai, R, Kirii, Y, Yokota, K, Tada, T, Matsumoto, T. 登録日 2012-01-05 公開日 2012-02-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state J.Biochem., 151, 2012
1W6I	plasmepsin II-pepstatin A complex 分子名称: PEPSTATIN, PLASMEPSIN 2 PRECURSOR 著者 Lindberg, J, Johansson, P.-O, Rosenquist, A, Kvarnstroem, I, Vrang, L, Samuelsson, B, Unge, T. 登録日 2004-08-18 公開日 2006-07-05 最終更新日 2018-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Study of a Novel Inhibitor with Bulky P1 Side Chain in Complex with Plasmepsin II -Implications for Drug Design To be Published
1WAK	X-ray structure of SRPK1 分子名称: 1,2-ETHANEDIOL, SERINE/THREONINE-PROTEIN KINASE SPRK1 著者 Ngo, J.C, Gullingsrud, J, Chakrabarti, S, Nolen, B, Aubol, B.E, Fu, X.D, Adams, J.A, Mccammon, J.A, Ghosh, G. 登録日 2004-10-26 公開日 2006-07-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Sr Protein Kinase 1 is Resilient to Inactivation. Structure, 15, 2007
2D9H	Solution structure of the forth and fifth zf-C2H2 domains of zinc finger protein 692 分子名称: ZINC ION, Zinc finger protein 692 著者 Zhang, H.P, Nagasima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-09 公開日 2006-06-09 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the forth and fifth zf-C2H2 domains of zinc finger protein 692 to be published
3GFE	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide 著者 Mohr, C, Jordan, S. 登録日 2009-02-26 公開日 2009-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 19, 2009
1JVP	Crystal structure of human CDK2 (unphosphorylated) in complex with PKF049-365 分子名称: 3-pyridin-4-yl-2,4-dihydroindeno[1,2-c]pyrazole, Cell division protein kinase 2 著者 Rondeau, J.M. 登録日 2001-08-31 公開日 2001-12-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Structure-based design and protein X-ray analysis of a protein kinase inhibitor. Bioorg.Med.Chem.Lett., 12, 2002
2D2N	Structure of an extracellular giant hemoglobin of the gutless beard worm Oligobrachia mashikoi 分子名称: Giant hemoglobin, A1(b) globin chain, A2(a5) globin chain, ... 著者 Numoto, N, Nakagawa, T, Kita, A, Sasayama, Y, Fukumori, Y, Miki, K. 登録日 2005-09-12 公開日 2005-10-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of an extracellular giant hemoglobin of the gutless beard worm Oligobrachia mashikoi. Proc.Natl.Acad.Sci.USA, 102, 2005
1JVU	CRYSTAL STRUCTURE OF RIBONUCLEASE A (COMPLEXED FORM) 分子名称: CYTIDINE-2'-MONOPHOSPHATE, RIBONUCLEASE A 著者 Vitagliano, L, Merlino, A, Zagari, A, Mazzarella, L. 登録日 2001-08-31 公開日 2002-06-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Reversible Substrate-Induced Domain Motions in Ribonuclease A Proteins, 46, 2002
1JWI	Crystal Structure of Bitiscetin, a von Willeband Factor-dependent Platelet Aggregation Inducer. 分子名称: bitiscetin, platelet aggregation inducer 著者 Hirotsu, S, Mizuno, H, Fukuda, K, Qi, M.C, Matsui, T, Hamako, J, Morita, T, Titani, K. 登録日 2001-09-04 公開日 2001-11-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of bitiscetin, a von Willebrand factor-dependent platelet aggregation inducer. Biochemistry, 40, 2001
1VMP	STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II 分子名称: PROTEIN (ANTI-HIV CHEMOKINE MIP VII) 著者 Liwang, A.C, Wang, Z.-X, Sun, Y, Peiper, S.C, Liwang, P.J. 登録日 1999-03-25 公開日 1999-11-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 The solution structure of the anti-HIV chemokine vMIP-II. Protein Sci., 8, 1999
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK 分子名称: Csk Homologous Kinase 著者 Murthy, T.V.S, Webster, G.D. 登録日 2001-09-04 公開日 2001-09-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1K1B	Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family 分子名称: B-cell lymphoma 3-encoded protein 著者 Michel, F, Soler-Lopez, M, Petosa, C, Cramer, P, Siebenlist, U, Mueller, C.W. 登録日 2001-09-24 公開日 2001-11-21 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J., 20, 2001
1VPL	Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution 分子名称: ABC transporter, ATP-binding protein, SULFATE ION 著者 Joint Center for Structural Genomics (JCSG) 登録日 2004-11-10 公開日 2004-11-23 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution To be published
3W2C	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV 分子名称: 2-{4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-1H-pyrazol-1-yl}-N-(3-methylbutyl)acetamide, Aurora kinase A 著者 Oliveira, T.M, Kairies, N.A, Engh, R.A. 登録日 2012-11-28 公開日 2014-02-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Flexibility and multiple conformations of the activation and glycine rich loops of aurora A accompanying inhibitor binding To be Published
2D2E	Crystal structure of atypical cytoplasmic ABC-ATPase SufC from Thermus thermophilus HB8 分子名称: CHLORIDE ION, GLYCEROL, SufC protein 著者 Watanabe, S, Kita, A, Miki, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-09-08 公開日 2005-10-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Atypical Cytoplasmic ABC-ATPase SufC from Thermus thermophilus HB8. J.Mol.Biol., 353, 2005
3VC4	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1 著者 Liu, J. 登録日 2012-01-03 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
3FYJ	Crystal structure of an optimzied benzothiophene inhibitor bound to MAPKAP Kinase-2 (MK-2) 分子名称: (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, MAP kinase-activated protein kinase 2 著者 Kurumbail, R.G, Caspers, N. 登録日 2009-01-22 公開日 2009-04-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency. Bioorg.Med.Chem.Lett., 19, 2009
1W82	p38 Kinase crystal structure in complex with small molecule inhibitor 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[(3Z)-5-TERT-BUTYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-YLIDENE]-N'-(4-CHLOROPHENYL)UREA 著者 Tickle, J, Jhoti, H, Cleasby, A, Devine, L. 登録日 2004-09-16 公開日 2005-02-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation J.Med.Chem., 48, 2005

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