4YM0
 
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1UHZ
 | | Solution structure of dsRNA binding domain in Staufen homolog 2 | | 分子名称: | staufen (RNA binding protein) homolog 2 | | 著者 | He, F, Muto, Y, Obayashi, N, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Koboyashi, N, Tanaka, A, Osanai, T, Matsuo, Y, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-07-14 | | 公開日 | 2004-08-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of dsRNA binding domain in Staufen homolog 2
To be Published
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3HVL
 | | Tethered PXR-LBD/SRC-1p complexed with SR-12813 | | 分子名称: | Pregnane X receptor, Linker, Steroid receptor coactivator 1, ... | | 著者 | Lesburg, C.A, Wang, W, Prosise, W.W, Chen, J, Taremi, S.S, Le, H.V, Madison, V, Cui, X, Thomas, A, Cheng, K.C. | | 登録日 | 2009-06-16 | | 公開日 | 2009-08-04 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21, 2008
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5JAX
 | | PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP | | 分子名称: | 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, SODIUM ION, ... | | 著者 | Campbell, J.C, Sankaran, B, Kim, C.W. | | 登録日 | 2016-04-12 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.486 Å) | | 主引用文献 | Structural Basis of Analog Specificity in PKG I and II.
ACS Chem. Biol., 12, 2017
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1D8E
 | | Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. | | 分子名称: | ACETATE ION, FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), ... | | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | | 登録日 | 1999-10-22 | | 公開日 | 2000-03-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
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4YAT
 | | Crystal structure of TRIM24 PHD-bromodomain complexed with N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-4-methoxybenzene-1-sulfonamide (5b) | | 分子名称: | N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-4-methoxybenzenesulfonamide, Transcription intermediary factor 1-alpha, ZINC ION | | 著者 | Poncet-Montange, G, Palmer, W, Jones, P. | | 登録日 | 2015-02-17 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
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4YBT
 | | Crystal structure of TRIM24 PHD-bromodomain complexed with N-{1,3-dimethyl-2-oxo-6-[3-(oxolan-3-ylmethoxy)phenoxy]-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-1-methyl-1H-imidazole-4-sulfonamide (7l) | | 分子名称: | DIMETHYL SULFOXIDE, N-(1,3-dimethyl-2-oxo-6-{3-[(3S)-tetrahydrofuran-3-ylmethoxy]phenoxy}-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-imidazole-4-sulfonamide, Transcription intermediary factor 1-alpha, ... | | 著者 | Poncet-Montange, G, Palmer, W, Jones, P. | | 登録日 | 2015-02-19 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
J.Med.Chem., 59, 2016
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1UN5
 | | ARH-II, AN ANGIOGENIN/RNASE A CHIMERA | | 分子名称: | ANGIOGENIN, CITRIC ACID | | 著者 | Holloway, D.E, Baker, M.D, Acharya, K.R. | | 登録日 | 2003-09-04 | | 公開日 | 2004-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystallographic Studies on Structural Features that Determine the Enzymatic Specificity and Potency of Human Angiogenin: Thr44, Thr80 and Residues 38-41
Biochemistry, 43, 2004
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1UNC
 | | Solution structure of the human villin C-terminal headpiece subdomain | | 分子名称: | VILLIN 1 | | 著者 | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | 登録日 | 2003-09-09 | | 公開日 | 2004-07-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
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1UJJ
 | | VHS domain of human GGA1 complexed with C-terminal peptide from BACE | | 分子名称: | ADP-ribosylation factor binding protein GGA1, C-terminal peptide from Beta-secretase | | 著者 | Shiba, T, Kametaka, S, Kawasaki, M, Shibata, M, Waguri, S, Uchiyama, Y, Wakatsuki, S. | | 登録日 | 2003-08-05 | | 公開日 | 2004-05-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Insights into the Phosphoregulation of beta-Secretase Sorting Signal by the VHS Domain of GGA1
TRAFFIC, 5, 2004
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1UJK
 | | VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE | | 分子名称: | ADP-ribosylation factor binding protein GGA1, C-terminal peptide from Beta-secretase, IODIDE ION | | 著者 | Shiba, T, Kametaka, S, Kawasaki, M, Shibata, M, Waguri, S, Uchiyama, Y, Wakatsuki, S. | | 登録日 | 2003-08-05 | | 公開日 | 2004-05-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Insights into the Phosphoregulation of beta-Secretase Sorting Signal by the VHS Domain of GGA1
TRAFFIC, 5, 2004
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4YH4
 | | Crystal structure of human BRD4(1) in complex with 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one (compound 19d) | | 分子名称: | 4-[(5-phenylpyridin-3-yl)carbonyl]-3,4-dihydroquinoxalin-2(1H)-one, Bromodomain-containing protein 4, GLYCEROL, ... | | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | | 登録日 | 2015-02-26 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Bioorg.Med.Chem.Lett., 25, 2015
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1A04
 | | THE STRUCTURE OF THE NITRATE/NITRITE RESPONSE REGULATOR PROTEIN NARL IN THE MONOCLINIC C2 CRYSTAL FORM | | 分子名称: | NITRATE/NITRITE RESPONSE REGULATOR PROTEIN NARL | | 著者 | Baikalov, I, Schroder, I, Kaczor-Grzeskowiak, M, Cascio, D, Gunsalus, R.P, Dickerson, R.E. | | 登録日 | 1997-12-08 | | 公開日 | 1998-03-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | NarL dimerization? Suggestive evidence from a new crystal form
Biochemistry, 37, 1998
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3HL2
 | | The crystal structure of the human SepSecS-tRNASec complex | | 分子名称: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Monothiophosphate, O-phosphoseryl-tRNA(Sec) selenium transferase, ... | | 著者 | Palioura, S, Steitz, T.A, Soll, D, Simonovic, M. | | 登録日 | 2009-05-26 | | 公開日 | 2009-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
Science, 325, 2009
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5JIA
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4YM1
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5UVU
 | | BRD4_BD2_A-1461028 | | 分子名称: | 7-(cyclopropylmethyl)-2-methyl-10-[(methylsulfonyl)methyl]-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one, Bromodomain-containing protein 4 | | 著者 | Park, C.H. | | 登録日 | 2017-02-20 | | 公開日 | 2017-06-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Complex structure of BRD4_BD2_A-1461028
To Be Published
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5JN0
 | | CRK-II SH2 domain | | 分子名称: | CHLORIDE ION, CRK-II SH2 domain | | 著者 | Cho, J.-H. | | 登録日 | 2016-04-29 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.677 Å) | | 主引用文献 | CRK-II SH2 domain
To Be Published
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4YBQ
 | | Rat GLUT5 with Fv in the outward-open form | | 分子名称: | Solute carrier family 2, facilitated glucose transporter member 5, antibody Fv fragment heavy chain, ... | | 著者 | Nomura, N, Shimamura, T, Iwata, S. | | 登録日 | 2015-02-19 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Structure and mechanism of the mammalian fructose transporter GLUT5
Nature, 526, 2015
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3HLT
 | | The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2) | | 分子名称: | CHLORIDE ION, HDHD2, SODIUM ION, ... | | 著者 | Ugochukwu, E, Shafqat, N, Yue, W.W, Cocking, R, Bray, J.E, Muniz, J.R.C, Krojer, T, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | | 登録日 | 2009-05-28 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (HDHD2)
To be Published
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5IW0
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1UJR
 | | Solution structure of WWE domain in BAB28015 | | 分子名称: | hypothetical protein AK012080 | | 著者 | He, F, Muto, Y, Hamana, H, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Kobayashi, N, Tanaka, A, Osanai, T, Matsuo, Y, Ohara, O, Nagase, T, Kikuno, R, Nagayama, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-08-11 | | 公開日 | 2004-10-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of WWE domain in BAB28015
To be Published
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5J2D
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1UJY
 | | Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6 | | 分子名称: | Rho guanine nucleotide exchange factor 6 | | 著者 | He, F, Muto, Y, Uda, H, Koshiba, S, Shirouzu, M, Terada, T, Kigawa, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Kobayashi, N, Tanaka, A, Osanai, T, Matsuo, Y, Ohara, O, Nagase, T, Kikuno, R, Nagayama, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-08-12 | | 公開日 | 2004-02-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6
To be Published
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4Z35
 | | Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539 | | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 3-{1-[(2S,3S)-3-(4-acetyl-3,5-dimethoxyphenyl)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1H-pyrrol-3-yl}propanoic acid, Lysophosphatidic acid receptor 1,Soluble cytochrome b562 | | 著者 | Chrencik, J.E, Roth, C.B, Terakado, M, Kurata, H, Omi, R, Kihara, Y, Warshaviak, D, Nakade, S, Asmar-Rovira, G, Mileni, M, Mizuno, H, Griffith, M.T, Rodgers, C, Han, G.W, Velasquez, J, Chun, J, Stevens, R.C, Hanson, M.A, GPCR Network (GPCR) | | 登録日 | 2015-03-30 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Cell, 161, 2015
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