1AUZ
| SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES | 分子名称: | SPOIIAA | 著者 | Kovacs, H, Comfort, D, Lord, M, Campbell, I.D, Yudkin, M.D. | 登録日 | 1997-09-08 | 公開日 | 1998-07-01 | 最終更新日 | 2024-04-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis. Proc.Natl.Acad.Sci.USA, 95, 1998
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1BHI
| STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES | 分子名称: | CRE-BP1 | 著者 | Nagadoi, A, Nakazawa, K, Uda, H, Maekawa, T, Ishii, S, Nishimura, Y. | 登録日 | 1998-06-09 | 公開日 | 1999-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain. J.Mol.Biol., 287, 1999
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8BZ9
| single soak stabilizer for ERa - 14-3-3 interaction (AZ354) | 分子名称: | 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYG
| fragment-linked stabilizer for ERa - 14-3-3 interaction (1047648) | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, ~{N}-[2-[(2-carbamimidoyl-1-benzothiophen-4-yl)-methyl-amino]ethyl]-2-(4-chloranylphenoxy)-~{N},2-dimethyl-propanamide | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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7NR4
| X-RAY STRUCTURE OF PRMT6 IN COMPLEX WITH indazole type inhibitor | 分子名称: | (2~{S})-2-azanyl-~{N}-[3-[3-(dimethylsulfamoyl)phenyl]-2~{H}-indazol-5-yl]propanamide, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Steuber, H. | 登録日 | 2021-03-02 | 公開日 | 2021-04-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*. Chemmedchem, 16, 2021
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8CAF
| N8C_Fab3b in complex with NEDD8-CUL1(WHB) | 分子名称: | Cullin-1, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A. | 登録日 | 2023-01-24 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nat.Chem.Biol., 19, 2023
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1BI8
| MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX | 分子名称: | CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR | 著者 | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | 登録日 | 1998-06-22 | 公開日 | 1999-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395, 1998
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8C2E
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8C2F
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7NVQ
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7O07
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8BZF
| FC-J acetonide stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin J-acetonide, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BYX
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8BZC
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8BZM
| FOXK1-ELF1-heterodimer bound to DNA | 分子名称: | DNA, ETS-related transcription factor Elf-1, Forkhead box protein K1, ... | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | 登録日 | 2022-12-15 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | FOXK1-ELF1_heterodimer bound to DNA To Be Published
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7O7K
| Crystal structure of the human DYRK1A kinase domain bound to abemaciclib | 分子名称: | 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Kaltheuner, I.H, Anand, K, Geyer, M. | 登録日 | 2021-04-13 | 公開日 | 2021-11-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12, 2021
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7O7I
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8C28
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7O7J
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8C30
| Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment | 分子名称: | 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ... | 著者 | Lau, R, Ottmann, C. | 登録日 | 2022-12-23 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | 14-3-3/Pyrin complex To Be Published
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8C2Y
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8COG
| Human arginylated beta-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Pinto, C.S, Bakker, S.E, Suchenko, A, Hussain, H, Hatano, T, Sampath, K, Chinthalapudi, K, Mishima, M, Balasubramanian, M. | 登録日 | 2023-02-28 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.499 Å) | 主引用文献 | Structure and physiological investigation of human arginylated beta-actin To Be Published
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7NUE
| Crystal structure of mouse PRMT6 in complex with inhibitor EML736 | 分子名称: | Protein arginine N-methyltransferase 6, methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate | 著者 | Bonnefond, L, Cavarelli, J. | 登録日 | 2021-03-11 | 公開日 | 2022-03-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
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7NUD
| Crystal structure of mouse PRMT6 in complex with inhibitor EML734 | 分子名称: | Protein arginine N-methyltransferase 6, methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate | 著者 | Bonnefond, L, Cavarelli, J. | 登録日 | 2021-03-11 | 公開日 | 2022-03-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J.Med.Chem., 65, 2022
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1BUZ
| SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | SPOIIAA | 著者 | Kovacs, H, Comfort, D, Lord, M, Campbell, I.D, Yudkin, M.D. | 登録日 | 1997-09-08 | 公開日 | 1998-07-01 | 最終更新日 | 2024-04-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis. Proc.Natl.Acad.Sci.USA, 95, 1998
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