7NR4

X-RAY STRUCTURE OF PRMT6 IN COMPLEX WITH indazole type inhibitor

Summary for 7NR4

Entry DOI	10.2210/pdb7nr4/pdb
Descriptor	Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, (2~{S})-2-azanyl-~{N}-[3-[3-(dimethylsulfamoyl)phenyl]-2~{H}-indazol-5-yl]propanamide, ... (4 entities in total)
Functional Keywords	protein arginine methyl transferase 6, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	171385.70
Authors	Steuber, H. (deposition date: 2021-03-02, release date: 2021-04-07, Last modification date: 2024-01-31)
Primary citation	Sutherland, M.,Li, A.,Kaghad, A.,Panagopoulos, D.,Li, F.,Szewczyk, M.,Smil, D.,Scholten, C.,Bouche, L.,Stellfeld, T.,Arrowsmith, C.H.,Barsyte, D.,Vedadi, M.,Hartung, I.V.,Steuber, H.,Britton, R.,Santhakumar, V. *Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics.** Chemmedchem, 16:1116-1125, 2021 Cited by PubMed: 33513288 DOI: 10.1002/cmdc.202100018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation