7NR4
X-RAY STRUCTURE OF PRMT6 IN COMPLEX WITH indazole type inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protein arginine N-methyltransferase 6 | polymer | 376 | 42074.6 | 4 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | E, G, I, K (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | F, H, J, L (A, B, C, D) | (2~{S})-2-azanyl-~{N}-[3-[3-(dimethylsulfamoyl)phenyl]-2~{H}-indazol-5-yl]propanamide | non-polymer | 387.5 | 4 | Chemie (UO2) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 433 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 194 | Ala 194 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168298.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3087.5 | |
| All* | Total formula weight | 171385.7 |
