7O7I
Crystal structure of the human HIPK3 kinase domain
Summary for 7O7I
| Entry DOI | 10.2210/pdb7o7i/pdb |
| Descriptor | Homeodomain-interacting protein kinase 3, 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | serine/threonine kinase, cmgc kinase, transcription, homeodomain-interacting protein kinase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 46206.91 |
| Authors | Kaltheuner, I.H.,Anand, K.,Geyer, M. (deposition date: 2021-04-13, release date: 2021-11-24, Last modification date: 2024-01-31) |
| Primary citation | Kaltheuner, I.H.,Anand, K.,Moecking, J.,Duster, R.,Wang, J.,Gray, N.S.,Geyer, M. Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. Nat Commun, 12:6607-6607, 2021 Cited by PubMed: 34785661DOI: 10.1038/s41467-021-26935-z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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