PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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2FV9	Crystal structure of TACE in complex with JMV 390-1 分子名称: ADAM 17, N-[(2R)-2-BENZYL-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ISOLEUCYL-L-LEUCINE, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... 著者 Orth, P. 登録日 2006-01-30 公開日 2006-03-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies. Protein Eng.Des.Sel., 19, 2006
2FP9	Crystal structure of Native Strictosidine Synthase 分子名称: L(+)-TARTARIC ACID, Strictosidine synthase 著者 Panjikar, S. 登録日 2006-01-16 公開日 2006-05-23 最終更新日 2019-07-10 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins Plant Cell, 18, 2006
2YDK	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas 分子名称: 2-(CARBAMOYLAMINO)-5-PHENYL-N-[(3S)-PIPERIDIN-3-YL]THIOPHENE-3-CARBOXAMIDE, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. 登録日 2011-03-22 公開日 2012-04-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas. J.Med.Chem., 55, 2012
2YDL	Crystal structure of SH3C from CIN85 分子名称: SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1 著者 Bravo, J, Cardenes, N. 登録日 2011-03-22 公開日 2012-03-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications. Plos One, 8, 2013
2YWP	Crystal Structure of CHK1 with a Urea Inhibitor 分子名称: 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA, Serine/threonine-protein kinase Chk1 著者 Park, C. 登録日 2007-04-21 公開日 2007-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors Bioorg.Med.Chem.Lett., 16, 2006
2YDI	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas 分子名称: 5-[4-(2-DIMETHYLAMINOETHYLOXY)PHENYL]-2-UREIDO-THIOPHENE-3-CARBOXAMIDE, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. 登録日 2011-03-21 公開日 2012-04-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas. J.Med.Chem., 55, 2012
2Y95	Solution structure of AUCG tetraloop hairpin found in human Xist RNA A-repeats essential for X-inactivation 分子名称: 5'-R(*GP*GP*CP*GP*CP*AP*UP*CP*GP*GP*CP*GP*CP*C)-3' 著者 Duszczyk, M.M, Sattler, M. 登録日 2011-02-11 公開日 2011-10-26 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 The Xist RNA A-Repeat Comprises a Novel Aucg Tetraloop Fold and a Platform for Multimerization. RNA, 17, 2011
2Z31	Crystal structure of immune receptor complex 分子名称: H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain precursor, ... 著者 Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. 登録日 2007-05-30 公開日 2007-10-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
3AG0	Crystal structure of carbonmonoxy human cytoglobin 分子名称: CARBON MONOXIDE, Cytoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Makino, M, Sawai, H, Shiro, Y, Sugimoto, H. 登録日 2010-03-17 公開日 2011-02-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the carbon monoxide complex of human cytoglobin Proteins, 79, 2011
2YHB	Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains 分子名称: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION 著者 Boland, A, Weichenrieder, O. 登録日 2011-04-27 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein Proc.Natl.Acad.Sci.USA, 108, 2011
2ZJU	Crystal Structure of Lymnaea stagnalis Acetylcholine Binding Protein (Ls-AChBP) Complexed with Imidacloprid 分子名称: (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, Acetylcholine-binding protein 著者 Okajima, T, Ihara, M, Yamashita, A, Oda, T, Morimoto, T, Matsuda, K. 登録日 2008-03-10 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin Invert.Neurosci., 8, 2008
2ZOL	Crystal structure of H-2Db in complex with the W513S variant of JHMV epitope S510 分子名称: 9-meric peptide from Spike glycoprotein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... 著者 Theodossis, A, Dunstone, M.A, Rossjohn, J. 登録日 2008-05-22 公開日 2008-06-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol., 180, 2008
3BIZ	Wee1 kinase complex with inhibitor PD331618 分子名称: 4-(2-chlorophenyl)-8-[3-(dimethylamino)propoxy]-9-hydroxy-6-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, CHLORIDE ION, Wee1-like protein kinase 著者 Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. 登録日 2007-12-02 公開日 2007-12-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18, 2008
3BES	Structure of a Poxvirus ifngbp/ifng Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon gamma, Interferon-gamma binding protein C4R, ... 著者 Nuara, A.A, Walter, M.R. 登録日 2007-11-20 公開日 2008-02-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein. Proc.Natl.Acad.Sci.Usa, 105, 2008
3AUM	Crystal structure of OspA mutant 分子名称: Outer surface protein A 著者 Makabe, K. 登録日 2011-02-10 公開日 2012-02-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Aromatic cluster mutations produce focal modulations of beta-sheet structure. Protein Sci., 24, 2015
3C84	Crystal structure of a complex of AChBP from aplysia californica and the neonicotinoid thiacloprid 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, Soluble acetylcholine receptor, ... 著者 Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. 登録日 2008-02-08 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc.Natl.Acad.Sci.Usa, 105, 2008
3BLU	crystal structure YopH complexed with inhibitor PVS 分子名称: (ethenylsulfonyl)benzene, Tyrosine-protein phosphatase yopH 著者 Liu, S, Zhang, Z.-Y. 登録日 2007-12-11 公開日 2008-10-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases J.Am.Chem.Soc., 130, 2008
3BIC	Crystal structure of human methylmalonyl-CoA mutase 分子名称: CHLORIDE ION, Methylmalonyl-CoA mutase, mitochondrial precursor 著者 Ugochukwu, E, Kochan, G, Pantic, N, Parizotto, E, Pilka, E.S, Pike, A.C.W, Gileadi, O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2007-11-30 公開日 2007-12-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J.Biol.Chem., 285, 2010
3BI6	Wee1 kinase complex with inhibitor PD352396 分子名称: 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide, CHLORIDE ION, Wee1-like protein kinase 著者 Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. 登録日 2007-11-29 公開日 2007-12-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18, 2008
2YER	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors 分子名称: 1,2-ETHANEDIOL, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, ... 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A, Otterbein, L. 登録日 2011-03-30 公開日 2012-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
2Z4E	Crystal Structure of D-Dimer from Human Fibrin Complexed with Gly-His-Arg-Pro-Tyr-amide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Doolittle, R.F, Pandi, L. 登録日 2007-06-16 公開日 2007-10-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini Biochemistry, 46, 2007
3C79	Crystal structure of Aplysia californica AChBP in complex with the neonicotinoid imidacloprid 分子名称: (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, ISOPROPYL ALCOHOL, Soluble acetylcholine receptor 著者 Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. 登録日 2008-02-06 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc.Natl.Acad.Sci.Usa, 105, 2008
3BLT	Crystal structures of YopH complexed with PVSN and PVS, inhibitors of YopH which co-valent bind to Cys of active site 分子名称: Tyrosine-protein phosphatase yopH, phenyl ethenesulfonate 著者 Liu, S, Zhang, Z.-Y. 登録日 2007-12-11 公開日 2009-02-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J.Am.Chem.Soc., 130, 2008
3BT2	Structure of urokinase receptor, urokinase and vitronectin complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ... 著者 Huang, M. 登録日 2007-12-27 公開日 2008-03-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes Nat.Struct.Mol.Biol., 15, 2008
3BJY	Catalytic core of Rev1 in complex with DNA (modified template guanine) and incoming nucleotide 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*DAP*DTP*DCP*DCP*DTP*DCP*DCP*DCP*DCP*DTP*DAP*(DOC))-3'), DNA (5'-D(*DTP*DAP*DAP*(P)P*DGP*DTP*DAP*DGP*DGP*DGP*DGP*DAP*DGP*DGP*DAP*DT)-3'), ... 著者 Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. 登録日 2007-12-05 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase Structure, 16, 2008

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