Summary for 2YWP
Entry DOI | 10.2210/pdb2ywp/pdb |
Related | 2AYP |
Descriptor | Serine/threonine-protein kinase Chk1, 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA (2 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31402.47 |
Authors | Park, C. (deposition date: 2007-04-21, release date: 2007-05-08, Last modification date: 2024-03-13) |
Primary citation | Li, G.,Hasvold, L.A.,Tao, Z.-F.,Wang, G.T.,Gwaltney II, S.L.,Patel, J.,Kovar, P.,Credo, R.B.,Chen, Z.,Zhang, H.,Park, C.,Sham, H.L.,Sowin, T.,Rosenberg, S.H.,Lin, N.-H. Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors Bioorg.Med.Chem.Lett., 16:2293-2298, 2006 Cited by PubMed: 16446090DOI: 10.1016/j.bmcl.2006.01.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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