PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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5IHC	MELK in complex with NVS-MELK12B 分子名称: 4-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine, Maternal embryonic leucine zipper kinase 著者 Sprague, E.R, Brazell, T. 登録日 2016-02-29 公開日 2016-06-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
4YE4	Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ... 著者 Kwong, P.D, Chen, L, Zhou, T. 登録日 2015-02-23 公開日 2015-07-22 最終更新日 2022-03-30 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
4YJQ	SYK kinase domain in complex with inhibitor GTC000224 分子名称: 3-[1H-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol, Tyrosine-protein kinase SYK 著者 Somers, D.O, Neu, M, Stuckey, J. 登録日 2015-03-03 公開日 2015-09-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg. Med. Chem. Lett., 21, 2011
4YJR	SYK kinase domain in complex with inhibitor GTC000225 分子名称: 3-(1H-indazol-4-yl{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol, Tyrosine-protein kinase SYK 著者 Somers, D.O, Neu, M, Stuckey, J. 登録日 2015-03-03 公開日 2015-09-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg. Med. Chem. Lett., 21, 2011
1TZB	Crystal structure of native phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum 分子名称: GLYCEROL, SULFATE ION, glucose-6-phosphate isomerase, ... 著者 Swan, M.K, Hansen, T, Schoenheit, P, Davies, C. 登録日 2004-07-09 公開日 2004-07-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution J.Biol.Chem., 279, 2004
4YX5	SpaO(SPOA1,2) 分子名称: CHLORIDE ION, Surface presentation of antigens protein SpaO 著者 Notti, R.Q, Stebbins, C.E. 登録日 2015-03-22 公開日 2015-06-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9001 Å) 主引用文献 A common assembly module in injectisome and flagellar type III secretion sorting platforms. Nat Commun, 6, 2015
1PUD	TRNA-GUANINE TRANSGLYCOSYLASE 分子名称: TRNA-GUANINE TRANSGLYCOSYLASE, ZINC ION 著者 Romier, C, Reuter, K, Suck, D, Ficner, R. 登録日 1996-06-28 公開日 1997-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. EMBO J., 15, 1996
4E05	Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ... 著者 Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. 登録日 2012-03-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109, 2012
4E06	Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ... 著者 Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. 登録日 2012-03-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.196 Å) 主引用文献 Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109, 2012
3NM8	Crystal structure of Tyrosinase from Bacillus megaterium 分子名称: CHLORIDE ION, COPPER (II) ION, Tyrosinase, ... 著者 Sendovski, M, Kanteev, M, Adir, N, Fishman, A. 登録日 2010-06-22 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 First structures of an active bacterial tyrosinase reveal copper plasticity J.Mol.Biol., 405, 2011
4PY4	Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2 分子名称: 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide, Poly [ADP-ribose] polymerase 14 著者 Li, J, Xu, Y. 登録日 2014-03-26 公開日 2015-04-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors Tetrahedron, 70, 2017
5A8D	The high resolution structure of a novel alpha-L-arabinofuranosidase (CtGH43) from Clostridium thermocellum ATCC 27405 分子名称: ACETATE ION, CARBOHYDRATE BINDING FAMILY 6, GLYCEROL, ... 著者 Goyal, A, Ahmed, S, Sharma, K, Fontes, C.M.G.A, Najmudin, S. 登録日 2015-07-14 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Molecular determinants of substrate specificity revealed by the structure of Clostridium thermocellum arabinofuranosidase 43A from glycosyl hydrolase family 43 subfamily 16. Acta Crystallogr D Struct Biol, 72, 2016
5IH9	MELK in complex with NVS-MELK8A 分子名称: 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine, Maternal embryonic leucine zipper kinase 著者 Sprague, E.R, Puleo, D.E. 登録日 2016-02-29 公開日 2016-06-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
5IH8	MELK in complex with NVS-MELK1 分子名称: Maternal embryonic leucine zipper kinase, N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide 著者 Sprague, E.R, Puleo, D.E. 登録日 2016-02-29 公開日 2016-06-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
2WDC	Termus thermophilus Sulfate thiohydrolase SoxB in complex with glycerol 分子名称: ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... 著者 Sauve, V, Roversi, P, Leath, K.J, Garman, E.F, Antrobus, R, Lea, S.M, Berks, B.C. 登録日 2009-03-24 公開日 2009-06-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase Soxb. J.Biol.Chem., 284, 2009
4E6S	Crystal structure of the SCAN domain from mouse Zfp206 分子名称: Zinc finger and SCAN domain-containing protein 10 著者 Liang, Y, Choo, S.H, Rossbach, M, Baburajendran, N, Palasingam, P, Kolatkar, P.R. 登録日 2012-03-15 公開日 2012-05-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Acta Crystallogr.,Sect.F, 68, 2012
4X62	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus 分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. 登録日 2014-12-06 公開日 2015-11-18 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (3.4492 Å) 主引用文献 N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat.Struct.Mol.Biol., 23, 2016
4X65	Crystal Structure of 30S ribosomal subunit from Thermus thermophilus 分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. 登録日 2014-12-06 公開日 2015-11-18 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (3.345 Å) 主引用文献 N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat.Struct.Mol.Biol., 23, 2016
6ESQ	Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA 分子名称: CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ... 著者 Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T. 登録日 2017-10-24 公開日 2018-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4XDK	Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine 分子名称: (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2014-12-19 公開日 2015-03-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
4EQ5	DNA ligase from the archaeon Thermococcus sibiricus 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 著者 Petrova, T, Bezsudnova, E.Y, Dorokhov, B.D, Slutskaya, E.S, Polyakov, K.M, Dorovatovskiy, P.V, Ravin, N.V, Skryabin, K.G, Kovalchuk, M.V, Popov, V.O. 登録日 2012-04-18 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable DNA ligase from the archaeon Thermococcus sibiricus. Acta Crystallogr.,Sect.F, 68, 2012
3N0H	hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex 分子名称: Dihydrofolate reductase, SULFATE ION, TRIMETHOPRIM 著者 Cody, V. 登録日 2010-05-14 公開日 2011-09-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176, 2011
5G2O	Yersinia pestis FabV variant T276A 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DIMETHYL SULFOXIDE, Enoyl-[acyl-carrier-protein] reductase [NADH] 著者 Pschibul, A, Kuper, J, HIrschbeck, M, Kisker, C. 登録日 2016-04-11 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia Pestis Fabv Enoyl-Acp Reductase. Biochemistry, 55, 2016
5ISY	Crystal structure of Nudix family protein with NAD 分子名称: NADH pyrophosphatase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION 著者 Zhang, D, Guan, Z, Zou, T, Yin, P. 登録日 2016-03-15 公開日 2016-09-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.354 Å) 主引用文献 Structural basis of prokaryotic NAD-RNA decapping by NudC Cell Res., 26, 2016
3N25	The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+ 分子名称: 1,2-ETHANEDIOL, GLYCEROL, MANGANESE (II) ION, ... 著者 Fenton, A.W, Johnson, T.A, Holyoak, T. 登録日 2010-05-17 公開日 2010-07-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Sci., 19, 2010

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