PDB: 226262 件ウェブページステータス検索Chemie searchBIRD

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6KNM	Apelin receptor in complex with single domain antibody 分子名称: Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION 著者 Ma, Y.B, Ding, Y, Song, X, Ma, X, Li, X, Zhang, N, Song, Y, Sun, Y, Shen, Y, Zhong, W, Hu, L.A, Ma, Y.L, Zhang, M.Y. 登録日 2019-08-06 公開日 2020-01-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure-guided discovery of a single-domain antibody agonist against human apelin receptor. Sci Adv, 6, 2020
6KNV	THRb mutation with a novel agonist 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-08-07 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
2VEW	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR 分子名称: 3-fluoro-N-[(1S)-1-[4-[(2-fluorophenyl)methyl]imidazol-2-yl]-2-[4-[(5S)-1,1,3-trioxo-1,2-thiazolidin-5-yl]phenyl]ethyl]benzenesulfonamide, MAGNESIUM ION, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 著者 Douty, B, Wayland, B, Ala, P.J, Bower, M.J, Pruitt, J, Bostrom, L, Wei, M, Klabe, R, Gonneville, L, Wynn, R, Burn, T.C, Liu, P.C.C, Combs, A.P, Yue, E.W. 登録日 2007-10-27 公開日 2007-11-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines Bioorg.Med.Chem.Lett., 18, 2008
8HPW	Crystal structure of mouse LGI1 LRR domain in space group P21 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich glioma-inactivated protein 1 著者 Liu, H, Xu, F. 登録日 2022-12-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Crystal structure of mouse LGI1 LRR domain in space group P21 To Be Published
6JZ4	b-glucuronidase from Ruminococcus gnavus in complex with D-glucaro-d-lactam 分子名称: (2S,3R,4S,5R)-3,4,5-trihydroxy-6-oxopiperidine-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, Beta-glucuronidase 著者 Dashnyam, P, Lin, H.Y. 登録日 2019-04-30 公開日 2020-06-03 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.712 Å) 主引用文献 Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
8HPX	Structure of mouse LGI1 LRR domain in space group P65 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich glioma-inactivated protein 1 著者 Liu, H, Xu, F. 登録日 2022-12-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.68 Å) 主引用文献 Structure of mouse LGI1 LRR domain in space group P65 To Be Published
8HQ2	Crystal structure of human ADAM22 in complex with human LGI1 mutant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ... 著者 Liu, H, Lin, Z, Xu, F. 登録日 2022-12-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Crystal structure of human ADAM22 in complex with human LGI1 mutant To Be Published
8HLK	Structure of McyB-C1A1 complexed with L-Leu and AMP 分子名称: ADENOSINE MONOPHOSPHATE, LEUCINE, Microcystin synthetase B (Fragment) 著者 Peng, Y.J. 登録日 2022-11-30 公開日 2023-12-13 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains. Structure, 32, 2024
6JVG	Crystal structure of human MTH1 in complex with compound MI0639 分子名称: 5-ethyl-4-methyl-6-(morpholin-4-yl)pyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase 著者 Peng, C, Cheng, Y.S. 登録日 2019-04-17 公開日 2020-10-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.844 Å) 主引用文献 Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
8HE9	Crystal structure of CTSB in complex with K777 分子名称: Cathepsin B, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Wang, H, Li, D, Sun, L, Yang, H. 登録日 2022-11-07 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
6JVQ	Crystal structure of human MTH1 in complex with compound MI1025 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-6-morpholin-4-yl-pyrimidine-2,4-diamine 著者 Peng, C, Li, Y.H, Cheng, Y.S. 登録日 2019-04-17 公開日 2020-10-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
6K1Y	Crystal structure of Rhodothermus marinus substrate-binding protein at pH 7.5 分子名称: ABC-type uncharacterized transport system periplasmic component-like protein 著者 Nam, K.H. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Rhodothermus marinus substrate-binding protein at pH 7.5 To Be Published
8HOJ	Crystal structure of UGT71AP2 in complex with UDP 分子名称: UGT71AP2, URIDINE-5'-DIPHOSPHATE 著者 Wang, Z.L, He, C, Li, F, Qiao, X, Ye, M. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2024-09-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Functional characterization, structural basis, and protein engineering of a rare flavonoid 2'- O -glycosyltransferase from Scutellaria baicalensis . Acta Pharm Sin B, 14, 2024
8HPY	Crystal structure of human LGI1-ADAM22 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ... 著者 Liu, H, Xu, F. 登録日 2022-12-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (5.87 Å) 主引用文献 Crystal structure of human LGI1-ADAM22 complex To Be Published
6JZ1	Apo structure of b-glucuronidase from Ruminococcus gnavus at 1.7 Angstrom resolution 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Beta-glucuronidase 著者 Dashnyam, P, Lin, H.Y. 登録日 2019-04-30 公開日 2020-06-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
8HQ1	Crystal Structure Of Human Lgi1-Adam22 Complex In Space Group C2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ... 著者 Liu, H.L, Lin, Z.H, Xu, F. 登録日 2022-12-13 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (4.17 Å) 主引用文献 Structure Of Human Lgi1-Adam22 Complex In Space Group C2 To Be Published
8HPU	Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ... 著者 Gao, G.F, Liu, S. 登録日 2022-12-13 公開日 2023-12-20 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (2.56 Å) 主引用文献 Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine. Cell Discov, 9, 2023
6K9T	Crystal structure of a class C beta-lactamase in complex with cefotaxime 分子名称: Beta-lactamase, CEFOTAXIME, C3' cleaved, ... 著者 Bae, D.W, Jung, Y.E, An, Y.J, Na, J.H, Cha, S.S. 登録日 2019-06-17 公開日 2019-10-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.459 Å) 主引用文献 Structural Insights into Catalytic Relevances of Substrate Poses in ACC-1. Antimicrob.Agents Chemother., 63, 2019
6QEQ	PcfF from Enterococcus faecalis pCF10 分子名称: PcfF 著者 Rehman, S, Berntsson, R.P.A. 登録日 2019-01-08 公開日 2019-05-01 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Enterococcal PcfF Is a Ribbon-Helix-Helix Protein That Recruits the Relaxase PcfG Through Binding and Bending of the oriT Sequence. Front Microbiol, 10, 2019
6KNZ	Crystal structure of T2R-TTL-KXO1 complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, CALCIUM ION, ... 著者 Chen, Q, Yu, Y. 登録日 2019-08-07 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.475 Å) 主引用文献 Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity. J.Biol.Chem., 294, 2019
8HNA	Crystal structure of N-terminal fragment (20-221aa) of human SCARF1 分子名称: Scavenger receptor class F member 1 著者 Wang, Y, He, Y, Li, G. 登録日 2022-12-07 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of N-terminal of SCARF1 at 2.6 Angstroms resolution To Be Published
6KAB	Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2 分子名称: (3~{S})-3-(cyclohexylmethyl)-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase 著者 Zhou, J, Fang, P. 登録日 2019-06-21 公開日 2020-04-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.892 Å) 主引用文献 Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
6A96	Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ... 著者 Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S. 登録日 2018-07-11 公開日 2018-10-03 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor. Cell Res., 28, 2018
6KCB	Room temperature structure of lysozyme delivered in shortening A by serial millisecond crystallography 分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION 著者 Nam, K.H. 登録日 2019-06-27 公開日 2020-05-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Shortening injection matrix for serial crystallography. Sci Rep, 10, 2020
8HN0	Crystal structure of N-terminal fragment (20-132aa) of human SCARF1 分子名称: Scavenger receptor class F member 1 著者 Wang, Y, He, Y. 登録日 2022-12-06 公開日 2023-12-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the f1 of SCARF1 To Be Published

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