6KNZ

Crystal structure of T2R-TTL-KXO1 complex

Summary for 6KNZ

• Entry DOI: 10.2210/pdb6knz/pdb
• Descriptor: Tubulin alpha-1B chain, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, inhibitor, complex, structural protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 6
• Total formula weight: 265438.45

Authors

Chen, Q.,Yu, Y. (deposition date: 2019-08-07, release date: 2019-10-23, Last modification date: 2023-11-22)

• Primary citation: Niu, L.,Yang, J.,Yan, W.,Yu, Y.,Zheng, Y.,Ye, H.,Chen, Q.,Chen, L.; Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.; J.Biol.Chem., 294:18099-18108, 2019; PubMed: 31628188; DOI: 10.1074/jbc.RA119.010732

Experimental method

X-RAY DIFFRACTION (2.475 Å)