6KAB

Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2

Summary for 6KAB

• Entry DOI: 10.2210/pdb6kab/pdb
• Related: 6KA6
• Descriptor: Lysine--tRNA ligase, (3~{S})-3-(cyclohexylmethyl)-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, ligase
• Biological source: Plasmodium falciparum (isolate NF54)
• Total number of polymer chains: 4
• Total formula weight: 240818.62

Authors

Zhou, J.,Fang, P. (deposition date: 2019-06-21, release date: 2020-04-08, Last modification date: 2023-11-22)

• Primary citation: Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.; Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.; Acs Chem.Biol., 15:1016-1025, 2020; PubMed: 32195573; DOI: 10.1021/acschembio.0c00032

Experimental method

X-RAY DIFFRACTION (2.892 Å)