6KA6
Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
Summary for 6KA6
Entry DOI | 10.2210/pdb6ka6/pdb |
Descriptor | Lysine--tRNA ligase, (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, ligase |
Biological source | Plasmodium falciparum (isolate NF54) |
Total number of polymer chains | 4 |
Total formula weight | 241243.10 |
Authors | |
Primary citation | Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P. Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15:1016-1025, 2020 Cited by PubMed: 32195573DOI: 10.1021/acschembio.0c00032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.891 Å) |
Structure validation
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