6KA6

Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1

Summary for 6KA6

• Entry DOI: 10.2210/pdb6ka6/pdb
• Descriptor: Lysine--tRNA ligase, (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, ligase
• Biological source: Plasmodium falciparum (isolate NF54)
• Total number of polymer chains: 4
• Total formula weight: 241243.10

Authors

Zhou, J.,Fang, P. (deposition date: 2019-06-21, release date: 2020-04-08, Last modification date: 2023-11-22)

• Primary citation: Zhou, J.,Zheng, L.,Hei, Z.,Li, W.,Wang, J.,Yu, B.,Fang, P.; Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.; Acs Chem.Biol., 15:1016-1025, 2020; PubMed: 32195573; DOI: 10.1021/acschembio.0c00032

Experimental method

X-RAY DIFFRACTION (1.891 Å)