6KA6

Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Lysine--tRNA ligase	polymer	516	59781.1	4	UniProt (W7JP72) Pfam (PF01336) Pfam (PF00152) In PDB	Plasmodium falciparum (isolate NF54)	Lysyl-tRNA synthetase
2	A, B, C, D	(3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one	non-polymer		290.4	4	Chemie (D4O)
3	A, B, D	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
4	A, B, C, D	LYSINE	non-polymer		147.2	4	Chemie (LYS)
5		water	water		18.0	1501	Chemie (HOH)

Sequence modifications

A, B, C, D: 77 - 583 (UniProt: W7JP72)

PDB	External Database	Details
Met 76	-	initiating methionine
Gly 584	-	expression tag
Gly 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag
His 590	-	expression tag
His 591	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	239124.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2118.6
All*	Total formula weight	241243.1

*Water molecules are not included.