6KA6
Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004824 | molecular_function | lysine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004824 | molecular_function | lysine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006430 | biological_process | lysyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue D4O A 601 |
| Chain | Residue |
| A | ARG330 |
| A | GLY554 |
| A | ARG559 |
| A | ILE570 |
| A | HOH818 |
| A | HOH832 |
| A | GLU332 |
| A | THR337 |
| A | HIS338 |
| A | ASN339 |
| A | PHE342 |
| A | GLU500 |
| A | LEU502 |
| A | ASN503 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | LYS321 |
| A | TRP349 |
| A | ALA350 |
| A | TYR351 |
| A | HOH704 |
| B | LYS105 |
| B | ARG108 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue LYS A 603 |
| Chain | Residue |
| A | GLY284 |
| A | GLU308 |
| A | ARG330 |
| A | GLU346 |
| A | TYR348 |
| A | ASN503 |
| A | TYR505 |
| A | GLU507 |
| A | GLY552 |
| A | HOH845 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue D4O B 601 |
| Chain | Residue |
| B | ARG330 |
| B | GLU332 |
| B | THR337 |
| B | HIS338 |
| B | ASN339 |
| B | PHE342 |
| B | GLU500 |
| B | VAL501 |
| B | LEU502 |
| B | ASN503 |
| B | GLY554 |
| B | ARG559 |
| B | ILE570 |
| B | LYS604 |
| B | HOH939 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| A | ILE258 |
| A | ARG262 |
| A | ILE325 |
| B | ARG262 |
| B | GLU272 |
| B | GLU274 |
| B | HOH747 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| A | LYS105 |
| A | GLU107 |
| B | LYS321 |
| B | TRP349 |
| B | ALA350 |
| B | TYR351 |
| B | HOH771 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue LYS B 604 |
| Chain | Residue |
| B | GLY284 |
| B | ALA285 |
| B | GLU308 |
| B | ARG330 |
| B | GLU346 |
| B | TYR348 |
| B | ASN503 |
| B | TYR505 |
| B | GLU507 |
| B | GLY552 |
| B | D4O601 |
| B | HOH758 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue D4O C 601 |
| Chain | Residue |
| C | ARG330 |
| C | GLU332 |
| C | THR337 |
| C | HIS338 |
| C | ASN339 |
| C | PHE342 |
| C | SER344 |
| C | GLU500 |
| C | LEU502 |
| C | ASN503 |
| C | GLY554 |
| C | ARG559 |
| C | ILE570 |
| C | LYS602 |
| C | HOH885 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue LYS C 602 |
| Chain | Residue |
| C | GLY284 |
| C | ALA285 |
| C | GLU308 |
| C | ARG330 |
| C | GLU346 |
| C | TYR348 |
| C | ASN503 |
| C | TYR505 |
| C | GLU507 |
| C | GLY552 |
| C | D4O601 |
| C | HOH747 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue D4O D 601 |
| Chain | Residue |
| D | ARG330 |
| D | GLU332 |
| D | THR337 |
| D | HIS338 |
| D | ASN339 |
| D | PHE342 |
| D | VAL501 |
| D | LEU502 |
| D | ASN503 |
| D | GLY554 |
| D | ARG559 |
| D | ILE570 |
| D | LYS603 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 602 |
| Chain | Residue |
| C | LYS105 |
| C | GLU107 |
| C | ARG108 |
| C | HOH788 |
| D | LYS321 |
| D | TRP349 |
| D | TYR351 |
| D | HOH752 |
| D | HOH905 |
| site_id | AD3 |
| Number of Residues | 13 |
| Details | binding site for residue LYS D 603 |
| Chain | Residue |
| D | GLY284 |
| D | ALA285 |
| D | GLU308 |
| D | ARG330 |
| D | GLU346 |
| D | TYR348 |
| D | ASN503 |
| D | TYR505 |
| D | GLU507 |
| D | GLY552 |
| D | GLY554 |
| D | D4O601 |
| D | HOH740 |
