PDB: 225158 件ウェブページステータス検索Chemie searchBIRD

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6F0T	Crystal structure of Pizza6-SFW 分子名称: GLYCEROL, Pizza6-SFW 著者 Noguchi, H, De Zitter, E, Van Meervelt, L, Voet, A.R.D. 登録日 2017-11-20 公開日 2018-03-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies. Biochem. Biophys. Res. Commun., 497, 2018
6PR2	R261A/S128A S. typhimurium siroheme synthase 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Pennington, J.M, Stroupe, M.E. 登録日 2019-07-10 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
4XU3	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose 分子名称: Bifunctional ligase/repressor BirA, CHLORIDE ION, N-({2-[(6-amino-9H-purin-9-yl)methoxy]ethyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.242677 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
7SJP	anti-HtrA1 Fab15H6.v4 bound to HtrA1-LoopA peptide 分子名称: GLYCEROL, Heavy Chain, HtrA1-LoopA peptide, ... 著者 Ultsch, M.H, Gerhardy, S. 登録日 2021-10-18 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun, 13, 2022
2L7H	The solution structure of the HAMP domain of the hypothetical transmembrane receptor Af1503 分子名称: Uncharacterized protein 著者 Coles, M, Hulko, M, Martin, J, Lupas, A.N. 登録日 2010-12-09 公開日 2011-01-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors. Structure, 19, 2011
6OZ5	Escherichia coli tRNA synthetase in complex with compound 3 分子名称: 1,2-ETHANEDIOL, 2-({[(2S)-1-cyclohexylpropan-2-yl]amino}methyl)phenol, DI(HYDROXYETHYL)ETHER, ... 著者 Kahne, D, Baidin, V, Owens, T.W. 登録日 2019-05-15 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
7RUH	Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844 分子名称: Bromodomain-containing protein 4, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(5-{[(2-fluorophenyl)carbamoyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indol-4-yl}-2,2,2-trifluoroethane-1-sulfonamide 著者 Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. 登録日 2021-08-17 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844 To Be Published
6PQ2	Structural Basis for Client Recognition and Activity of Hsp40 Chaperones 分子名称: Alkaline phosphatase,Chaperone DnaJ domain-containing protein fusion 著者 Jiang, Y, Rossi, P, Kalodimos, C.G. 登録日 2019-07-08 公開日 2019-09-18 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural basis for client recognition and activity of Hsp40 chaperones. Science, 365, 2019
6F4Z	2'F-araG modified quadruplex with flipped G-tract and central tetrad 分子名称: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*GP*(GFL)P*GP*GP*AP*CP*GP*GP*G)-3') 著者 Dickerhoff, J, Weisz, K. 登録日 2017-11-30 公開日 2018-04-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway. Chembiochem, 19, 2018
6P06	Ternary structure of the E52D mutant of ANT-4 with Neomycin and AMPCPP 分子名称: CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Kanamycin nucleotidyltransferase, ... 著者 Selvaraj, B, Cuneo, M.J. 登録日 2019-05-16 公開日 2020-01-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 "Catch and Release": a Variation of the Archetypal Nucleotidyl Transfer Reaction Acs Catalysis, 10, 2020
6F58	Crystal structure of human Brachyury (T) in complex with DNA 分子名称: Brachyury protein, DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3'), SODIUM ION 著者 Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2017-12-01 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.253 Å) 主引用文献 Crystal structure of human Brachyury (T) in complex with DNA To Be Published
6FB0	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Calcium 分子名称: ACETATE ION, CALCIUM ION, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ... 著者 Molina, R, Prieto, J. 登録日 2017-12-18 公開日 2018-07-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6P5X	Sirohydrochlorin-bound S. typhimurium siroheme synthase 分子名称: 3,3',3'',3'''-[(7S,8S,12S,13S)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13-tetrahydroporphyrin-2,7,12,18-tetrayl]tetrapropanoic acid, CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Pennington, J.M, Stroupe, M.E. 登録日 2019-05-31 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun, 11, 2020
7RUI	Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with XR844 分子名称: Bromodomain-containing protein 4, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(5-{[(2-fluorophenyl)carbamoyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indol-4-yl}-2,2,2-trifluoroethane-1-sulfonamide 著者 Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. 登録日 2021-08-17 公開日 2022-08-24 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with XR844 To Be Published
7SJM	anti-HtrA1 Fab15H6.v4 分子名称: GLYCEROL, Heavy Chain, Light Chain, ... 著者 Ultsch, M.H, Gerhardy, S. 登録日 2021-10-18 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun, 13, 2022
6P6I	Structure of YbtPQ importer 分子名称: ABC transporter protein, inner membrane ABC-transporter 著者 Wang, Z, Hu, W, Zheng, H. 登録日 2019-06-04 公開日 2020-03-04 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter. Sci Adv, 6, 2020
6FBU	Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate 分子名称: ACETATE ION, DNA (5'-D(P*CP*CP*AP*GP*GP*AP*(PED)P*GP*AP*AP*GP*CP*C)-3'), DNA (5'-D(P*GP*GP*CP*TP*TP*CP*AP*TP*CP*CP*TP*G)-3'), ... 著者 Pomyalov, S, Lansky, S, Golan, G, Zharkov, D.O, Grollman, A.P, Shoham, G. 登録日 2017-12-19 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the DNA repair enzyme endonuclease-VIII (Nei) from E. coli (E2Q) in complex with AP-site containing DNA substrate To Be Published
6P6X	Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state 分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein 著者 Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A. 登録日 2019-06-04 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel. Cell, 178, 2019
6P7F	Human ABCC6 NBD2 R1459D mutant in Apo state 分子名称: Multidrug resistance-associated protein 6, SULFATE ION 著者 Zheng, A, Thibodeau, P.H. 登録日 2019-06-05 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85004 Å) 主引用文献 Structures of human ABCC6 NBD1 and NBD2 To Be Published
4XTV	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide) 分子名称: Bifunctional ligase/repressor BirA, N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45000839 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XU1	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates a morpholine in place of the ribose 分子名称: 1,2-ETHANEDIOL, Bifunctional ligase/repressor BirA, DIMETHYL SULFOXIDE, ... 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.70001328 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
6PE5	Yeast Vo motor in complex with 2 VopQ molecules 分子名称: Cation transporter, Uncharacterized protein YPR170W-B, V-type proton ATPase subunit a, ... 著者 Peng, W, Li, Y, Tomchick, D.R, Orth, K. 登録日 2019-06-20 公開日 2020-05-20 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Nat.Struct.Mol.Biol., 27, 2020
6PF9	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid. 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, METHOTREXATE, ... 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
4XUH	PPARgamma ligand binding domain in complex with sulindac sulfide 分子名称: 2-[(3Z)-6-fluoranyl-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]ethanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Puhl, A.C, Polikaporv, I, Webb, P. 登録日 2015-01-25 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13, 2015
2L51	Solution structure of calcium bound S100A16 分子名称: CALCIUM ION, Protein S100-A16 著者 Babini, E, Bertini, I, Borsi, V, Calderone, V, Hu, X, Luchinat, C, Parigi, G. 登録日 2010-10-22 公開日 2010-11-03 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural characterization of human S100A16, a low-affinity calcium binder. J.Biol.Inorg.Chem., 16, 2011

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