7SJP

anti-HtrA1 Fab15H6.v4 bound to HtrA1-LoopA peptide

Summary for 7SJP

• Entry DOI: 10.2210/pdb7sjp/pdb
• Related: 7SJM
• Descriptor: HtrA1-LoopA peptide, Heavy Chain, Light Chain, ... (6 entities in total)
• Functional Keywords: fab htra 1 peptide complex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 49631.85

Authors

Ultsch, M.H.,Gerhardy, S. (deposition date: 2021-10-18, release date: 2022-09-07, Last modification date: 2023-10-18)

• Primary citation: Gerhardy, S.,Ultsch, M.,Tang, W.,Green, E.,Holden, J.K.,Li, W.,Estevez, A.,Arthur, C.,Tom, I.,Rohou, A.,Kirchhofer, D.; Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.; Nat Commun, 13:5222-5222, 2022; PubMed: 36064790; DOI: 10.1038/s41467-022-32760-9

Experimental method

X-RAY DIFFRACTION (2.1 Å)