7RUH

Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844

Summary for 7RUH

• Entry DOI: 10.2210/pdb7ruh/pdb
• Related: 7JKW 7JKX 7JKY 7JKZ
• Descriptor: Bromodomain-containing protein 4, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-(5-{[(2-fluorophenyl)carbamoyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indol-4-yl}-2,2,2-trifluoroethane-1-sulfonamide (3 entities in total)
• Functional Keywords: selective brd4-bd1 inhibitor, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15932.27

Authors

Ratia, K.M.,Xiong, R.,Li, Y.,Shen, Z.,Zhao, J.,Huang, F.,Dubrovyskyii, O.,Thatcher, G.R. (deposition date: 2021-08-17, release date: 2022-08-24, Last modification date: 2023-10-18)

• Primary citation: Xiong, R.,Ratia, K.M.,Li, Y.,Shen, Z.,Zhao, J.,Huang, F.,Dubrovyskyii, O.,Thatcher, G.R.; Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)