4YOO
 
 | | p107 pocket domain in complex with LIN52 P29A peptide | | 分子名称: | LIN52 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION | | 著者 | Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M. | | 登録日 | 2015-03-12 | | 公開日 | 2015-05-13 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
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2VT5
 | | FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE -1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH A DUAL BINDING AMP SITE INHIBITOR | | 分子名称: | 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE, FRUCTOSE-1,6-BISPHOSPHATASE 1 | | 著者 | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T. | | 登録日 | 2008-05-09 | | 公開日 | 2008-07-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Allosteric Fbpase Inhibitors Gain 10(5) Times in Potency When Simultaneously Binding Two Neighboring AMP Sites.
Bioorg.Med.Chem.Lett., 18, 2008
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2VUT
 | | Crystal structure of NAD-bound NmrA-AreA zinc finger complex | | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Kotaka, M, Johnson, C, Lamb, H.K, Hawkins, A.R, Ren, J, Stammers, D.K. | | 登録日 | 2008-05-30 | | 公開日 | 2008-07-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Analysis of the Recognition of the Negative Regulator Nmra and DNA by the Zinc Finger from the Gata-Type Transcription Factor Area.
J.Mol.Biol., 381, 2008
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7SHK
 | | Structure of Xenopus laevis CRL2Lrr1 (State 1) | | 分子名称: | CULLIN_2 domain-containing protein, Elongin-C, Lrr1, ... | | 著者 | Zhou, H, Brown, A. | | 登録日 | 2021-10-09 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Nucleic Acids Res., 49, 2021
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5A8Z
 | | Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(4R)-7-methyl-2,5-bis(oxidanylidene)-1-[3-(trifluoromethyl)phenyl]-3,4,6,8-tetrahydropyrimido[4,5-d]pyridazin-4-yl]benzenecarbonitrile, Neutrophil elastase, ... | | 著者 | von Nussbaum, F, Li, V.M, Meibom, D, Anlauf, S, Bechem, M, Delbeck, M, Gerisch, M, Harrenga, A, Karthaus, D, Lang, D, Lustig, K, Mittendorf, J, Schaefer, M, Schaefer, S, Schamberger, J. | | 登録日 | 2015-07-17 | | 公開日 | 2016-08-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
ChemMedChem, 11, 2016
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7SHL
 | | Structure of Xenopus laevis CRL2Lrr1 (State 2) | | 分子名称: | CULLIN_2 domain-containing protein, Elongin-C, Lrr1, ... | | 著者 | Zhou, H, Brown, A. | | 登録日 | 2021-10-09 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Nucleic Acids Res., 49, 2021
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8OQY
 | | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | | 登録日 | 2023-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform.
Nat Commun, 15, 2024
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8OQZ
 | | Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | | 登録日 | 2023-04-12 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform.
Nat Commun, 15, 2024
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4Y5I
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma | | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau | | 著者 | Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. | | 登録日 | 2015-02-11 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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5D1C
 | | Crystal structure of D233G-Y306F HDAC8 in complex with a tetrapeptide substrate | | 分子名称: | GLYCEROL, HDAC8 Fluor de Lys tetrapeptide substrate, Histone deacetylase 8, ... | | 著者 | Decroos, C, Christianson, N.H, Gullett, L.E, Bowman, C.M, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | | 登録日 | 2015-08-04 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.422 Å) | | 主引用文献 | Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
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5BQ8
 | | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form II | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Norrin | | 著者 | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | | 登録日 | 2015-05-28 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Elife, 4, 2015
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4OR9
 | | Crystal structure of human calcineurin | | 分子名称: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | | 著者 | Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | | 登録日 | 2014-02-11 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
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5R4O
 | | PanDDA analysis group deposition of ground-state model of BROMODOMAIN OF HUMAN NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, Nucleosome-remodeling factor subunit BPTF | | 著者 | Talon, R, Krojer, T, Fairhead, M, Sethi, R, Bradley, A.R, Aimon, A, Collins, P, Brandao-Neto, J, Douangamath, A, Wright, N, MacLean, E, Renjie, Z, Dias, A, Brennan, P.E, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2020-02-25 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | PanDDA analysis group deposition of ground-state model
To Be Published
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5BQE
 | | Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 -Methylated form | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | | 登録日 | 2015-05-28 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Elife, 4, 2015
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5BTV
 | | Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ottmann, C, Schumacher, B, Bartel, M. | | 登録日 | 2015-06-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2019-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Faseb J., 29, 2015
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5R4K
 | | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF in complex with FMOPL000292a | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, Nucleosome-remodeling factor subunit BPTF, ... | | 著者 | Talon, R, Krojer, T, Fairhead, M, Sethi, R, Bradley, A.R, Aimon, A, Collins, P, Brandao-Neto, J, Douangamath, A, Wright, N, MacLean, E, Renjie, Z, Dias, A, Brennan, P.E, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2020-02-24 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5R4I
 | | PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF in complex with FMOPL000443a | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(acetylamino)-N-(4H-1,2,4-triazol-4-yl)benzamide, DIMETHYL SULFOXIDE, ... | | 著者 | Talon, R, Krojer, T, Fairhead, M, Sethi, R, Bradley, A.R, Aimon, A, Collins, P, Brandao-Neto, J, Douangamath, A, Wright, N, MacLean, E, Renjie, Z, Dias, A, Brennan, P.E, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | 登録日 | 2020-02-24 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5DC8
 | | Crystal structure of H142A-Y306F HDAC8 in complex with a tetrapeptide substrate | | 分子名称: | Fluor-de-Lys tetrapeptide assay substrate, GLYCEROL, Histone deacetylase 8, ... | | 著者 | Decroos, C, Lee, M.S, Christianson, D.W. | | 登録日 | 2015-08-23 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Biochemistry, 55, 2016
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5NO6
 | | TEAD4-HOXB13 complex bound to DNA | | 分子名称: | DNA, Homeobox protein Hox-B13, Transcriptional enhancer factor TEF-3 | | 著者 | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | | 登録日 | 2017-04-11 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | TEAD4-HOXB13 complex bound to DNA
To Be Published
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4YWB
 | | Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and oxalic acid | | 分子名称: | 3-sulfanylpyridine-2-carboxylic acid, CHLORIDE ION, MANGANESE (II) ION, ... | | 著者 | Balan, M.D, Johnson, T.A, Lotosky, W.R, Mcleod, M.J, Holyoak, T. | | 登録日 | 2015-03-20 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid.
Biochemistry, 54, 2015
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2W9F
 | | Crystal Structure of CDK4 in complex with a D-type cyclin | | 分子名称: | CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 | | 著者 | Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. | | 登録日 | 2009-01-23 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2VUU
 | | Crystal structure of NADP-bound NmrA-AreA zinc finger complex | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NITROGEN METABOLITE REPRESSION REGULATOR NMRA, NITROGEN REGULATORY PROTEIN AREA, ... | | 著者 | Kotaka, M, Johnson, C, Lamb, H.K, Hawkins, A.R, Ren, J, Stammers, D.K. | | 登録日 | 2008-05-30 | | 公開日 | 2008-07-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Analysis of the Recognition of the Negative Regulator Nmra and DNA by the Zinc Finger from the Gata-Type Transcription Factor Area.
J.Mol.Biol., 381, 2008
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7UAJ
 | | Crystal structure of apo HPV16 E6 | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Protein E6, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Shen, Q, Leonard, P.G, Cross, J.B. | | 登録日 | 2022-03-13 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Disorder-to-order transition of the interdomain linker of HPV E6 upon E6AP binding reshapes p53 binding pocket
To Be Published
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5BK4
 | | Cryo-EM structure of Mcm2-7 double hexamer on dsDNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (60-mer), strand 1, ... | | 著者 | Li, H, Yuan, Z, Bai, L. | | 登録日 | 2017-09-12 | | 公開日 | 2017-10-25 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1ERW
 | | HUMAN THIOREDOXIN DOUBLE MUTANT WITH CYS 32 REPLACED BY SER AND CYS 35 REPLACED BY SER | | 分子名称: | THIOREDOXIN | | 著者 | Weichsel, A, Gasdaska, J.R, Powis, G, Montfort, W.R. | | 登録日 | 1996-02-07 | | 公開日 | 1996-10-14 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.
Structure, 4, 1996
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