2VT5

FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE -1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH A DUAL BINDING AMP SITE INHIBITOR

Summary for 2VT5

• Entry DOI: 10.2210/pdb2vt5/pdb
• Related: 1FTA 2FHY 2FIE 2FIX 2JJK
• Descriptor: FRUCTOSE-1,6-BISPHOSPHATASE 1, 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE (3 entities in total)
• Functional Keywords: hydrolase (phosphoric monoester), disease mutation, allosteric enzyme, zinc, hydrolase, polymorphism, gluconeogenesis, carbohydrate metabolism
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 8
• Total formula weight: 297078.13

Authors

Ruf, A.,Joseph, C.,Benz, J.,Fol, B.,Tetaz, T. (deposition date: 2008-05-09, release date: 2008-07-22, Last modification date: 2011-07-13)

• Primary citation: Hebeisen, P.,Kuhn, B.,Kohler, P.,Gubler, M.,Huber, W.,Kitas, E.,Schott, B.,Benz, J.,Joseph, C.,Ruf, A.; Allosteric Fbpase Inhibitors Gain 10(5) Times in Potency When Simultaneously Binding Two Neighboring AMP Sites.; Bioorg.Med.Chem.Lett., 18:4708-, 2008; PubMed: 18650089; DOI: 10.1016/J.BMCL.2008.06.103

Experimental method

X-RAY DIFFRACTION (2.2 Å)