8RHB
 
 | | Microtubule-associated kinesin-1 tail complex bound to AMPPNP, single-headed state | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kif5b Tail, ... | | 著者 | Atherton, J, Chegkazi, M.S, Steiner, R.A. | | 登録日 | 2023-12-15 | | 公開日 | 2024-11-20 | | 最終更新日 | 2025-07-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail.
Nat Commun, 16, 2025
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9CV9
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7B45
 | | Notum complex with ARUK3003934 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-methylsulfanylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, ... | | 著者 | Fish, P, Jones, E.Y. | | 登録日 | 2020-12-02 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J.Med.Chem., 65, 2022
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8RHH
 | | Microtubule-associated kinesin-1 tail complex bound to AMPPNP, two-headed state | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... | | 著者 | Atherton, J, Chegkazi, M.S, Steiner, R.A. | | 登録日 | 2023-12-15 | | 公開日 | 2024-11-20 | | 最終更新日 | 2025-07-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail.
Nat Commun, 16, 2025
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7B8N
 | | Notum-Fragment 197 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-azanyl-2-(pyridin-3-ylmethylamino)benzoic acid, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-13 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B4X
 | | Notum complex with ARUK3002697 | | 分子名称: | 1,2-ETHANEDIOL, 6-(4-methylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, DIMETHYL SULFOXIDE, ... | | 著者 | Jones, E.Y, Fish, P. | | 登録日 | 2020-12-02 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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6HCZ
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6FAO
 | | Discovery and characterization of a thermostable GH6 endoglucanase from a compost metagenome | | 分子名称: | 1,2-ETHANEDIOL, Glycoside hydrolase family 6, SULFATE ION | | 著者 | Jensen, M.S, Fredriksen, L, MacKenzie, A.K, Pope, P.B, Chylenski, P, Leiros, I, Williamson, A.K, Christopeit, T, Ostby, H, Vaaje-Kolstad, G, Eijsink, V.G.H. | | 登録日 | 2017-12-15 | | 公開日 | 2018-06-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome.
PLoS ONE, 13, 2018
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9CUZ
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8K32
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6ZIV
 | | Crystal structure of a Beta-glucosidase from Alicyclobacillus acidiphilus | | 分子名称: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase, ... | | 著者 | Gourlay, L.J. | | 登録日 | 2020-06-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Producing natural vanilla extract from green vanilla beans using a beta-glucosidase from Alicyclobacillus acidiphilus.
J.Biotechnol., 329, 2021
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6SYI
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5N1P
 | | Crystal structure of the polysaccharide deacetylase Bc1974 from Bacillus cereus in complex with N-hydroxynaphthalene-1-carboxamide | | 分子名称: | 1,2-ETHANEDIOL, Peptidoglycan N-acetylglucosamine deacetylase, SODIUM ION, ... | | 著者 | Giastas, P, Andreou, A, Eliopoulos, E.E. | | 登録日 | 2017-02-06 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.448 Å) | | 主引用文献 | Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors.
Biochemistry, 57, 2018
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9FOP
 | | Half-closed CODH/ACS (Class 1) in the methylated state | | 分子名称: | CO-dehydrogenase, CO-methylating acetyl-CoA synthase, Fe(3)-Ni(1)-S(4) cluster, ... | | 著者 | Ruickoldt, J, Wendler, P, Dobbek, H. | | 登録日 | 2024-06-12 | | 公開日 | 2025-06-25 | | 最終更新日 | 2025-09-17 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Ligand binding to a Ni-Fe cluster orchestrates conformational changes of the CO-dehydrogenase-acetyl-CoA synthase complex.
Nat Catal, 8, 2025
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7BP6
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6X3N
 | | Co-structure of BTK kinase domain with L-005085737 inhibitor | | 分子名称: | 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, 4-{8-amino-3-[(6R,8aS)-3-oxohexahydro-3H-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide, Tyrosine-protein kinase BTK | | 著者 | Fischmann, T.O. | | 登録日 | 2020-05-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg.Med.Chem.Lett., 30, 2020
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6THI
 | | Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus | | 分子名称: | Sodium channel neurotoxin MeuNaTxalpha-1 | | 著者 | Mineev, K.S, Kuzmenkov, A.I, Khusainov, G.A, Arseniev, A.S, Vassilevski, A.A. | | 登録日 | 2019-11-20 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of MeuNaTx alpha-1 toxin from scorpion venom highlights the importance of the nest motif.
Proteins, 2021
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9D6D
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5NQF
 | | Crystal structure of Plasmodium falciparum AMA1 in complex with a 39 aa PvRON2 peptide | | 分子名称: | Apical membrane antigen 1, Rhoptry neck protein 2 | | 著者 | Vulliez-le Normand, B, Saul, F.A, Faber, B.W, Bentley, G.A. | | 登録日 | 2017-04-20 | | 公開日 | 2017-09-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study.
PLoS ONE, 12, 2017
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6H79
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8AV0
 | | small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3 | | 分子名称: | 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
Acs Cent.Sci., 9, 2023
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8EVJ
 | | CX3CR1 nucleosome bound PU.1 and C/EBPa | | 分子名称: | DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Guan, R, Bai, Y, Lian, T. | | 登録日 | 2022-10-20 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha.
Nat.Struct.Mol.Biol., 31, 2024
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8EVI
 | | CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations | | 分子名称: | DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | | 著者 | Lian, T, Guan, R, Bai, Y. | | 登録日 | 2022-10-20 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha.
Nat.Struct.Mol.Biol., 31, 2024
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5F8Z
 | | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1 | | 分子名称: | CYS-PRO-ALA-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein LIGHT CHAIN, SULFATE ION, ... | | 著者 | Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M. | | 登録日 | 2015-12-09 | | 公開日 | 2016-12-14 | | 最終更新日 | 2025-09-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1
To Be Published
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7RXR
 | | Crystal Structure of BRD4(D1) with 4-[4-(4-bromophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-N-(3,5-dimethylphenyl)pyrimidin-2-amine | | 分子名称: | 1,2-ETHANEDIOL, 4-[4-(4-bromophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-N-(3,5-dimethylphenyl)pyrimidin-2-amine, Bromodomain-containing protein 4 | | 著者 | Cui, H, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. | | 登録日 | 2021-08-23 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
J.Med.Chem., 65, 2022
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