PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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6BQ1	Human PI4KIIIa lipid kinase complex 分子名称: 5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, Phosphatidylinositol 4-kinase III alpha (PI4KA), Protein FAM126A, ... 著者 Lees, J.A, Zhang, Y, Oh, M, Schauder, C.M, Yu, X, Baskin, J, Dobbs, K, Notarangelo, L.D, Camilli, P.D, Walz, T, Reinisch, K.M. 登録日 2017-11-27 公開日 2017-12-13 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Architecture of the human PI4KIII alpha lipid kinase complex. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BJS	CryoEM structure of E.coli his pause elongation complex without pause hairpin 分子名称: DNA (32-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Kang, J.Y, Landick, R, Darst, S.A. 登録日 2017-11-06 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing. Mol. Cell, 69, 2018
6BQN	Cryo-EM structure of ENaC 分子名称: 10D4 fab, 7B1 fab, EGFP-SCNN1G chimera, ... 著者 Noreng, S, Bharadwaj, A, Posert, R, Yoshioka, C, Baconguis, I. 登録日 2017-11-28 公開日 2018-10-10 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structure of the human epithelial sodium channel by cryo-electron microscopy. Elife, 7, 2018
4ZER	Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ... 著者 Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A. 登録日 2015-04-20 公開日 2015-05-20 最終更新日 2025-03-12 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat.Struct.Mol.Biol., 22, 2015
3EUE	Crystal structure of ligand-free human uridine phosphorylase 1 (hUPP1) 分子名称: MAGNESIUM ION, SULFATE ION, Uridine phosphorylase 1 著者 Roosild, T.P. 登録日 2008-10-09 公開日 2009-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. Bmc Struct.Biol., 9, 2009
6NEV	FAD-dependent monooxygenase TropB from T. stipitatus Y239F Variant 分子名称: CHLORIDE ION, FAD-dependent monooxygenase tropB, FLAVIN-ADENINE DINUCLEOTIDE 著者 Rodriguez Benitez, A, Tweedy, S.E, Baker Dockrey, S.A, Lukowski, A.L, Wymore, T, Khare, D, Palfey, B.A, Smith, J.L, Narayan, A.R.H. 登録日 2018-12-18 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 Structural basis for selectivity in flavin-dependent monooxygenase-catalyzed oxidative dearomatization. Acs Catalysis, 9, 2019
4LR8	Phosphopentomutase S154A variant soaked with ribose 5-phosphate 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-alpha-D-ribofuranose, ACETATE ION, ... 著者 Birmingham, W.A, Starbird, C.A, Panosian, T.D, Nannemann, D.P, Iverson, T.M, Bachmann, B.O. 登録日 2013-07-19 公開日 2013-07-31 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nat.Chem.Biol., 10, 2014
6HKA	The solution structure of the micelle-associated FATC domain of the human protein kinase ataxia telangiectasia mutated (ATM) 分子名称: Immunoglobulin G-binding protein G,Serine-protein kinase ATM 著者 Abd Rahim, M.S, Dames, S.A. 登録日 2018-09-06 公開日 2019-03-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NMR- and MD simulation-based structural characterization of the membrane-associating FATC domain of ataxia telangiectasia mutated. J.Biol.Chem., 294, 2019
7JGK	Crystal Structure of the Ni-bound Human Heavy-chain variant 122H-delta C-star with 2,5-furandihyrdoxamate collected at 100K 分子名称: Ferritin heavy chain, NICKEL (II) ION, N~2~,N~5~-dihydroxyfuran-2,5-dicarboxamide, ... 著者 Bailey, J.B, Tezcan, F.A. 登録日 2020-07-19 公開日 2020-10-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks. J.Am.Chem.Soc., 142, 2020
7JGQ	Crystal Structure of the Ni-bound Human Heavy-chain variant 122H-delta C-star with 2,5-furandihyrdoxamate collected at 278K after one heating/cooling cycle 分子名称: Ferritin heavy chain, NICKEL (II) ION, N~2~,N~5~-dihydroxyfuran-2,5-dicarboxamide, ... 著者 Bailey, J.B, Tezcan, F.A. 登録日 2020-07-19 公開日 2020-10-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks. J.Am.Chem.Soc., 142, 2020
3EUF	Crystal structure of BAU-bound human uridine phosphorylase 1 分子名称: 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE, PHOSPHATE ION, Uridine phosphorylase 1 著者 Roosild, T.P. 登録日 2008-10-10 公開日 2009-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. Bmc Struct.Biol., 9, 2009
6K4Y	CryoEM structure of sigma appropriation complex 分子名称: 10 kDa anti-sigma factor, DNA (60-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Shi, J, Wen, A, Feng, Y. 登録日 2019-05-27 公開日 2019-08-07 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.79 Å) 主引用文献 Structural basis of sigma appropriation. Nucleic Acids Res., 47, 2019
5I8Q	S. cerevisiae Prp43 in complex with RNA and ADPNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ... 著者 He, Y, Nielsen, K.H, Andersen, G.R. 登録日 2016-02-19 公開日 2017-02-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.2 Å) 主引用文献 Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA, 23, 2017
8XSX	Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Cheng, J. 登録日 2024-01-10 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (4.104 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
8XSZ	Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Cheng, J. 登録日 2024-01-10 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
8XSY	Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled) 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Cheng, J. 登録日 2024-01-10 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
6R9G	Structural basis of transcription inhibition by the DNA mimic Ocr protein of bacteriophage T7 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ye, F.Z, Zhang, X.D. 登録日 2019-04-03 公開日 2020-02-26 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7. Elife, 9, 2020
4QKW	Crystal structure of the zebrafish cavin4a HR1 domain 分子名称: CHLORIDE ION, Muscle-related coiled-coil protein 著者 Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. 登録日 2014-06-10 公開日 2015-03-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into the organization of the cavin membrane coat complex Dev.Cell, 31, 2014
8AX9	Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121) 分子名称: Maltose/maltodextrin-binding periplasmic protein,Apolipoprotein E 著者 Nemergut, M, Marek, M. 登録日 2022-08-31 公開日 2023-08-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.549 Å) 主引用文献 Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate. Mol Neurodegener, 18, 2023
7JGN	Crystal Structure of the Zn-bound Human Heavy-chain variant 122H-delta C-star with meta-benzenedihyrdoxamate collected at 100K 分子名称: Ferritin heavy chain, N~1~,N~3~-dihydroxybenzene-1,3-dicarboxamide, SODIUM ION, ... 著者 Bailey, J.B, Tezcan, F.A. 登録日 2020-07-19 公開日 2020-10-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks. J.Am.Chem.Soc., 142, 2020
4LR9	Phosphopentomutase S154A variant soaked with 2,3-dideoxyribose 5-phosphate 分子名称: 2,3-dideoxy-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, MANGANESE (II) ION, ... 著者 Birmingham, W.A, Starbird, C.A, Panosian, T.D, Nannemann, D.P, Iverson, T.M, Bachmann, B.O. 登録日 2013-07-19 公開日 2013-07-31 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nat.Chem.Biol., 10, 2014
8YOP	Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Denk, T, Cheng, J. 登録日 2024-03-13 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
8YOO	Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Denk, T, Cheng, J. 登録日 2024-03-13 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
7D94	Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the presence of bufalin 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. 登録日 2020-10-12 公開日 2021-01-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021

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